ID   ATR4_STEAL              Reviewed;         552 AA.
AC   A0A8F4PNE5;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2022, sequence version 1.
DT   03-AUG-2022, entry version 3.
DE   RecName: Full=MFS-type transporter atr4 {ECO:0000303|PubMed:34154413};
DE   AltName: Full=Atranorin biosynthesis cluster protein 4 {ECO:0000303|PubMed:34154413};
GN   Name=atr4 {ECO:0000303|PubMed:34154413};
OS   Stereocaulon alpinum (Alpine snow lichen) (Stereocaulon paschale var.
OS   alpinum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Lecanoromycetes;
OC   OSLEUM clade; Lecanoromycetidae; Lecanorales; Lecanorineae;
OC   Stereocaulaceae; Stereocaulon.
OX   NCBI_TaxID=350623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=34154413; DOI=10.1128/mbio.01111-21;
RA   Kim W., Liu R., Woo S., Kang K.B., Park H., Yu Y.H., Ha H.H., Oh S.Y.,
RA   Yang J.H., Kim H., Yun S.H., Hur J.S.;
RT   "Linking a gene cluster to atranorin, a major cortical substance of
RT   lichens, through genetic dereplication and heterologous expression.";
RL   MBio 12:e0111121-e0111121(2021).
CC   -!- FUNCTION: MFS-type transporter; part of the gene cluster that mediates
CC       the biosynthesis of atranorin, a depside of polyketide origin that
CC       accumulates in the cortical or medullary layers of lichen thalli.
CC       {ECO:0000269|PubMed:34154413}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; MZ277876; QXF68950.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; Membrane; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..552
FT                   /note="MFS-type transporter atr4"
FT                   /id="PRO_0000455744"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        385..405
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        425..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        452..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        498..518
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        521..541
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        73
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        314
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   552 AA;  59981 MW;  AC141B3E70D30939 CRC64;
     MEDPKSLSAP LTAFNADTTT ADETPAAQKK YEDDNGQKAG SESSENTKNS DHGDATEVNT
     PKSADLEANA LRNSSVSRSN QEQEKSEEAI DPNIVDWDGP NDPSNPLNWP TWKIKTHIFL
     VSSITFISPL GSSILATGIP QILAEFRSTN AELGSLVVSV YLLGFAAGPL VIAPLSELYG
     RMPLYHICNI LFAILTVGCA LGPTLNSEIG LRFLQGCAGS APLAIGGGTI SDLIPQERRG
     KYMGIYALGP TLGPIFGPVA GGFLTGAKGW RWLMWLLLMI EGSVTLVNFV VMRETYGVVI
     MARKTRALQK QTGNMSLRSR YDQGLTTRRL WRNTLIRPAK MLVYSPIIFL LSLFMAMVYG
     YLYLLFTTFP VVFGEYYHFS IGITGLVYLG LGIGNIIGLV IFGVFSDKIL LAKAASGELK
     PEYRLLPMVW TSFTVPIGLF IYGWSARYAV HWIVPIIGTV FFGIGLLVTL VCTLTYIVDA
     FTEYAASATA ANAVMRSVVG ATLPLAGPSM YQALGIGWGN SLLAFIALAG CPIPWVFYVY
     GERIRKSSKA TY