ATR5_HYAAE
ID ATR5_HYAAE Reviewed; 367 AA.
AC M4C699; E6YE64;
DT 05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2013, sequence version 1.
DT 25-MAY-2022, entry version 17.
DE RecName: Full=Avirulence protein ATR5 {ECO:0000303|PubMed:21361788};
DE AltName: Full=Arabidopsis thaliana recognized protein 5 {ECO:0000303|PubMed:21361788};
DE Flags: Precursor;
GN Name=ATR5 {ECO:0000303|PubMed:21361788};
OS Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS (Peronospora arabidopsidis).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Hyaloperonospora.
OX NCBI_TaxID=559515;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DOMAIN, AND INDUCTION.
RC STRAIN=Emoy2;
RX PubMed=21361788; DOI=10.1094/mpmi-12-10-0278;
RA Bailey K., Cevik V., Holton N., Byrne-Richardson J., Sohn K.H., Coates M.,
RA Woods-Toer A., Aksoy H.M., Hughes L., Baxter L., Jones J.D., Beynon J.,
RA Holub E.B., Toer M.;
RT "Molecular cloning of ATR5(Emoy2) from Hyaloperonospora arabidopsidis, an
RT avirulence determinant that triggers RPP5-mediated defense in
RT Arabidopsis.";
RL Mol. Plant Microbe Interact. 24:827-838(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Emoy2;
RX PubMed=21148394; DOI=10.1126/science.1195203;
RA Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K., Dong S.,
RA Downton P., Dumas B., Fabro G., Fronick C., Fuerstenberg S.I., Fulton L.,
RA Gaulin E., Govers F., Hughes L., Humphray S., Jiang R.H., Judelson H.,
RA Kamoun S., Kyung K., Meijer H., Minx P., Morris P., Nelson J.,
RA Phuntumart V., Qutob D., Rehmany A., Rougon-Cardoso A., Ryden P.,
RA Torto-Alalibo T., Studholme D., Wang Y., Win J., Wood J., Clifton S.W.,
RA Rogers J., Van den Ackerveken G., Jones J.D., McDowell J.M., Beynon J.,
RA Tyler B.M.;
RT "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora
RT arabidopsidis genome.";
RL Science 330:1549-1551(2010).
RN [3]
RP IDENTIFICATION.
RC STRAIN=Emoy2;
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Secreted effector that acts as an elicitor of hypersensitive
CC response (HR) specifically on plants carrying defense protein RPP5.
CC {ECO:0000269|PubMed:21361788}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:21361788}. Host cell
CC {ECO:0000305|PubMed:21361788}.
CC -!- INDUCTION: Expressed in spores as well as during host plant infection.
CC {ECO:0000269|PubMed:21361788}.
CC -!- DOMAIN: Has the canonical EER motif, but lacks the canonical
CC translocation motif RxLR, which characterizes most oomycete effectors
CC identified so far. The EER motif is not required to trigger an RPP5-
CC dependent immune response. {ECO:0000305|PubMed:21361788}.
CC -!- MISCELLANEOUS: The ATR5 effector protein is a polymorphic member of the
CC RXLR class and displays copy-number variation among different isolates
CC of H.arabidopsidis. {ECO:0000269|PubMed:21361788}.
CC -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR EMBL; FN598669; CBI63251.1; -; mRNA.
DR EMBL; JH597955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M4C699; -.
DR SMR; M4C699; -.
DR EnsemblProtists; HpaT814631; HpaP814631; HpaG814631.
DR VEuPathDB; FungiDB:HpaG814631; -.
DR HOGENOM; CLU_755352_0_0_1; -.
DR PHI-base; PHI:4735; -.
DR Proteomes; UP000011713; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0043657; C:host cell; IEA:UniProtKB-SubCell.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Secreted; Signal; Virulence.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..367
FT /note="Avirulence protein ATR5"
FT /id="PRO_0000447270"
FT REGION 33..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 61..64
FT /note="dEER"
FT /evidence="ECO:0000305|PubMed:21361788"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 367 AA; 41475 MW; 8ECF43F88031951E CRC64;
MRLISPALVV STAIQARHVN SSAPVDSAMT EANPLASAHP PDVGYDGVPA GRVRNPDDPT
TEERTPGESF MEAINFKIFK LVQEAQGRIL GLPEQPRGDM EWLERYGQDA ILHYLETGDK
DPSQLEKKYD QLLDELKNAP NLEVEILESI HALFLAYMEE VAKPAVQTTP KLNEQPDKFA
WAMINKARRN AKPGIRNPYK SLNIPLVENY IKKYNAFIEL RQRELTLLDT FSCAFNHNTV
KLAKFLAMVD TFSPKRTFVL AMRIELSEIW IEEKRTIAEV ASILGISTIT GYAKNRLSAG
TFVRFIYQLA KTNEQLGPDI VKDLVKTFGP DRTTELLTRM KTVSPRMFTI LKDHMDVRLK
ETGVTPN
