RPOB_CAMLR
ID RPOB_CAMLR Reviewed; 1377 AA.
AC B9KFG7;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=Cla_0449;
OS Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Campylobacteraceae; Campylobacter.
OX NCBI_TaxID=306263;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RM2100 / D67 / ATCC BAA-1060;
RX PubMed=18713059; DOI=10.1089/fpd.2008.0101;
RA Miller W.G., Wang G., Binnewies T.T., Parker C.T.;
RT "The complete genome sequence and analysis of the human pathogen
RT Campylobacter lari.";
RL Foodborne Pathog. Dis. 5:371-386(2008).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; CP000932; ACM63802.1; -; Genomic_DNA.
DR RefSeq; WP_012661185.1; NC_012039.1.
DR AlphaFoldDB; B9KFG7; -.
DR SMR; B9KFG7; -.
DR STRING; 306263.Cla_0449; -.
DR PRIDE; B9KFG7; -.
DR EnsemblBacteria; ACM63802; ACM63802; CLA_0449.
DR GeneID; 7411186; -.
DR KEGG; cla:CLA_0449; -.
DR PATRIC; fig|306263.5.peg.446; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_0_7; -.
DR OMA; FMTWEGY; -.
DR OrthoDB; 9601at2; -.
DR Proteomes; UP000007727; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 2.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 2.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription;
KW Transferase.
FT CHAIN 1..1377
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_1000165796"
SQ SEQUENCE 1377 AA; 155941 MW; 8A5C8A186BBAA378 CRC64;
MLNSQSGNRL RIDFSNVPQQ IDIPNLLQLQ KKSFDYFLNI DAKNSESGIE KVFKSIFPIH
DPQNRLSLEY VSSEVGKPKY TIRECMERGL TYSVNLKMKI RLTLHEKDEK TGEKIGIKDI
KEQEIYIREI PLMTDRISFI INGVERVVVN QLHRSPGVIF KEEESSTVAN KLVYTAQIIP
DRGSWLYFEY DAKDVLYVRI NKRRKVPITI LFRALGYKKQ DIIKLFYPIQ TIHVKKDKFL
TEFNPNDFLD RVEYDLKDEK GNIIHQAGKR MTKKKAEQLV KDGIKWVEYP VEILTNRYLA
NPIINKETGE VLFDSLTLLD ESKLAKIKEQ KTFDIANDLA NGVDAAIINS FIQDNETLKL
LKQTENIDDE NDLAAIRIYK VMRPGEPVVK DAAKAFVNDL FFNPERYDLT KVGRMKMNHK
LGLDTPEYVT VLTNEDIVKT AKYLIKVKNG RGHIDDRDHL GNRRIRSIGE LLANELHVGL
AKMQKAIRDK FTALNTDIDK VMPYDLINPK TITVTIMEFF TGGQLSQFMD QTNPLSEVTH
KRRLSALGEG GLVKERAGFE VRDVHATHYG RICPVETPEG QNIGLINTLS TYAKVNDLGF
VEAPYKKVEN GKVSNEIVYL TATQEEGLVI AAASTKIDEK GSIVEEFVEA RQDGETILAR
REEVHLIDLC SGMIVGVAAS LIPFLEHDDA NRALMGSNMQ RQAVPLLTAQ APIVGTGMEK
IIARDAWEAI KAKRAGIVEK VDNKNIFILG EDENGPFIDH YKMEKNLRTN QNTTFTQHPI
VKKGEFVQVG QIIADGPSMD QGELAIGKNA LIAFMPWHGY NYEDAIVISE KILREDTFTS
VHIYEKEVEA RELKDGVEEI TKDIPNVKED DLAHLDESGI AKIGTHIKPG MILVGKVSPK
GEVKPTPEER LLRAIFGEKA GHVVNKSLYA TASMEGVVVD VKIFTKKGYE KDARAIKAYD
EEKLNLEKEH HDRLLMMDRE ETLRVCSLLS KSALNSDEEI NGQKYKKGAK VDIKELEKIN
RFALNSLVKA YSKDVQKEYE DLKNHFQNEK KKLKSEHDEK LEILEKDDIL PSGVVKLVKV
YIATKRKLKV GDKMAGRHGN KGIVSNIVPE VDMPYLPDGR PIDIALNPLG VPSRMNIGQI
LESHLGIVGM RLGDQIQEIF DKKQKDFIKQ LRTKILEICS VSRLTLEKKF VESLNDEQLI
SYARDWARGV KFATPVFEGV TVEEFSKLFE MAKIAMDGKS ELYDGRTGEK MAERVHVGCM
YMLKLHHLVD EKVHARSTGP YSLVTQQPVG GKALFGGQRF GEMEVWALEA YGAAHTLREM
LTIKSDDVEG RFSAYKALTK GENVPATGIP ETFFVLTNEL KSLALDVEIF DKDENNE
