RPOB_CARHZ
ID RPOB_CARHZ Reviewed; 1132 AA.
AC Q3A9Q7;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=CHY_2318;
OS Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 /
OS Z-2901).
OC Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Carboxydothermus.
OX NCBI_TaxID=246194;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-161 / DSM 6008 / Z-2901;
RX PubMed=16311624; DOI=10.1371/journal.pgen.0010065;
RA Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J.,
RA Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J.,
RA Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A.;
RT "Life in hot carbon monoxide: the complete genome sequence of
RT Carboxydothermus hydrogenoformans Z-2901.";
RL PLoS Genet. 1:563-574(2005).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; CP000141; ABB14620.1; -; Genomic_DNA.
DR RefSeq; WP_011345200.1; NC_007503.1.
DR AlphaFoldDB; Q3A9Q7; -.
DR SMR; Q3A9Q7; -.
DR STRING; 246194.CHY_2318; -.
DR EnsemblBacteria; ABB14620; ABB14620; CHY_2318.
DR KEGG; chy:CHY_2318; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_1_9; -.
DR OMA; FMTWEGY; -.
DR OrthoDB; 9601at2; -.
DR Proteomes; UP000002706; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 2.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1132
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000224042"
SQ SEQUENCE 1132 AA; 127899 MW; 22370CA4AD5CF2F8 CRC64;
MIPVQVGKKI RYSYAKFPEI LELPYLIEIQ KKSYQWFLDE GLREVFREIS PITDFTGNLS
LEFLDYYLGK PKYSVEECKE RDFTYSAPLR VKVRLLNKET GEIKEQEVFL GDFPLMTEKG
TFIFNGAERV VISQMVRSPG VYFSEQVDPN GKKMYLATII PNRGAWLEFE TDVNDHIYVR
IDRTRKLPVT VLLKALGYES KGRIAELFDH DDKIIATLER DNTDSREEAL IEIYKKLRPG
EPPTVESAKT LLDSMFFDPK RYDLGNVGRY KLFKKLNHGV LYRYLEEDGE KEYDKYLNDY
VPVKREFIRE LTNEDIIYTI RYLLGLMRGQ GKVDDIDHLG NRRLRSVGEL LQNQFRIGLA
RMERVVRERM TIQDADSLTP QVLINTRPIV AAIKEFFGSS QLSQFMDQTN PLAELTHKRR
LSALGPGGLS RERAGFEVRD VHHSHYGRMC PIETPEGPNI GLIGNLTTYA RVNEFGFIET
PYRKVDKERG VVTNEIVYLT ADEEEKYIIA QANVRLSPEG KFLDEMVNAR HGSEILHVEP
SKVDFVDVSP KQVFSVATSL IPFLEHDDAN RALMGANMQR QAVPLIRTEA PVVGTGIEYK
AAKDSGVVVL AKNPGVVERV TADEIVIRND QGQIDRYKLI KFQRSNQGTC INQKPIVRKG
ERVEKDQIIA DGPSTDHGEL ALGKNVLVAY MPWEGYNYED AILISEKLVK EDVFTSIHIE
EYECDARDTK LGPEEITRDI PNVGEDALKD LDERGIIRIG AEVRPGDILV GKVTPKGETE
LTAEERLLRA IFGEKAREVR DTSLRVPHGE SGKVVDVKVF SRENGDELSP GVNMLVRVYI
AQKRKISVGD KMAGRHGNKG VVARILPEED MPFLPDGTPV EIVLNPLGVP SRMNIGQILE
CHLGWAAKAL GINVATPIFN GATEEDIFEA LRKAGLPEDG KIEVRDGRTG EPFDSRVTVG
YVYMLKLAHL VDDKIHARST GPYSLVTQQP LGGKAQFGGQ RFGEMEVWAL EAYGAAYTLQ
EILTIKSDDV VGRVKTYEAI VKGENIPEPG VPESFKVLIK ELQSLGLDVK VLTDNDEEVE
IKEIDDDIGE KAEEYGLAAS IADRDEVKNE YYEEEVEADF EINDDFDGDL ED
