RPOB_CARRP
ID RPOB_CARRP Reviewed; 1267 AA.
AC Q05FH8;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=DNA-directed RNA polymerase subunit beta;
DE Short=RNAP subunit beta;
DE EC=2.7.7.6;
DE AltName: Full=RNA polymerase subunit beta;
DE AltName: Full=Transcriptase subunit beta;
GN Name=rpoB; OrderedLocusNames=CRP_162;
OS Carsonella ruddii (strain PV).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Zymobacter group; Candidatus Carsonella.
OX NCBI_TaxID=387662;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PV;
RX PubMed=17038615; DOI=10.1126/science.1134196;
RA Nakabachi A., Yamashita A., Toh H., Ishikawa H., Dunbar H.E., Moran N.A.,
RA Hattori M.;
RT "The 160-kilobase genome of the bacterial endosymbiont Carsonella.";
RL Science 314:267-267(2006).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6;
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000305}.
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DR EMBL; AP009180; BAF35193.1; -; Genomic_DNA.
DR AlphaFoldDB; Q05FH8; -.
DR SMR; Q05FH8; -.
DR STRING; 387662.CRP_162; -.
DR PRIDE; Q05FH8; -.
DR EnsemblBacteria; BAF35193; BAF35193; CRP_162.
DR KEGG; crp:CRP_162; -.
DR HOGENOM; CLU_000524_4_0_6; -.
DR OMA; TIKVMCE; -.
DR Proteomes; UP000000777; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1267
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000300296"
SQ SEQUENCE 1267 AA; 149255 MW; 95F0479F8F734266 CRC64;
MINYLKFNRF CFSKKKFFHK CNLPYLLHNQ IGSYNSFLSS KYNSLFSIKK VLKQYFPLIC
NNKNIFIKLK KIELLEPCNT EKYTKIRNLH LFSTLYMYIS IYVINKNLNV YKKIFLGNIP
SMTKKGNFII NGIDRILISQ FTKSYGIYFY TEKKKKKCII IPLKGSWLEF IITNNFLIVF
DKKINFEINV FLICLGYNKK YFFNFFFFKI KIKIIRGKKR IFFLLNKKKY FYKIYNKYIC
ISIKKILGKL FGKNYFLKKN TFLKFNIIDI NKVNLILNYP IYFFFIIFLK KIINLNYLIY
IYKNFKLKIN KELLQYKKGY IINFFRNLFY KKKYFYSLIG AKRIFKRLFL KKNNKLTIYL
EIIKKILKFI KFNIQNDNFD NLENKLILNC GKLLSIKFDF LFKKVIKFIN YKMNNFKKYK
DLDFIVNSDI ITIGLKDYFC NNELSQFLDQ NNPLAEISHN RKISLISGIG IEKENCGFDI
RDIHYSHYCK VCPIDTPEGH NIGLINSLAY LSKVNKYNFI STIYKISILG KILGITFLDN
KFDKHKFIVN FNSTIETIYG EIFRSPYFEA RKTNYYYYKK FLNIDLIEIC GDQIISVGAS
LIPFLSHNDA NRCLMGSNMQ RQAVPLIDSE NPIVGTGNEL EIGLNSNYNI LSDLNGYVLY
SDNYKIIIKN NNFIKTYFLE KYTRTNQNTI LNQYTKVLKG DFVKVGNIIA DSNSTKNGEI
SLGKNLRVAF MSWYGYNFED SILLSSSILN KNNFNSIHIY EFITVLKYNE NGFEIVSNEC
FGSNEKIKNK VKNGIIKIGE FVFSKDVIVG KMIPKKKRKF SPEEKLFKIV FSESNFNYYE
QPLTVPKNIK GTIIAVNDFK IFYFKNKIFK LLKFEQLNYT CKNINNFFYE TFNYYLTKIK
KLLFNNKITI KKKRINSYNI NINNIFKIKC FNKKINFKLN IFKNIISNEL LKKKNIFVYK
KINFIKHDDF ENSIIRIIKI KIAVKKQIAI GDKMSGRHGN KGVVSNIIDY ENMPYDKFGN
KIDLILNPLG VPSRMNVGQL LEVFLAGSLN LIKSFFLKIK NLNKISYFKM KLFIKIIFKC
IYDKNINLNI FNNSLVLKIF KNIKNQLNVC VHNFYNFNVN KVNNIIKTIG INKNCELLLF
DGITGKRYLQ LVNVGYIYFM KLNHLVIDKI YSRSIGPYSI VTQQPLGGKS NLGGQRLGEM
EVWALEAYGA AFLLKEMLTI KSDDILGRIE LYKNIIKGIN DANSGIPESF QVLMKEIQSL
CFDIKIL
