RPOB_CHLAB
ID RPOB_CHLAB Reviewed; 1252 AA.
AC Q5L5I3;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=CAB661;
OS Chlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=218497;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 27085 / S26/3;
RX PubMed=15837807; DOI=10.1101/gr.3684805;
RA Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D.,
RA Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D.,
RA Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A.,
RA Price C., Barrell B.G., Parkhill J., Longbottom D.;
RT "The Chlamydophila abortus genome sequence reveals an array of variable
RT proteins that contribute to interspecies variation.";
RL Genome Res. 15:629-640(2005).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; CR848038; CAH64108.1; -; Genomic_DNA.
DR RefSeq; WP_011097244.1; NC_004552.2.
DR AlphaFoldDB; Q5L5I3; -.
DR SMR; Q5L5I3; -.
DR EnsemblBacteria; CAH64108; CAH64108; CAB661.
DR KEGG; cab:CAB661; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_1_0; -.
DR OMA; FMTWEGY; -.
DR OrthoDB; 9601at2; -.
DR Proteomes; UP000001012; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.40.270.10; -; 2.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription;
KW Transferase.
FT CHAIN 1..1252
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000224044"
SQ SEQUENCE 1252 AA; 140335 MW; 76077AC3D9913595 CRC64;
MFKCPERVSV KKKEDILDLP NLIEIQIKSY KQFLQIGKLA EERDNIGLEE VFREIFPIKS
YNEATILEYL SYNLGVPKYS PDECIRRGIT YSVTLKVRFR LTDETGIKEE EVYMGTIPIM
TDKGTFIING AERVVVSQVH RSPGINFEQE KHSKGNILFS FRIIPYRGSW LEAIFDINDL
IYIHIDRKKR RRKILAITFI RALGYSSDAD IIEEFFQIEE HSLKSEKDFS FLVGKILADN
VLDEASSLVY GKAGEKLSTA MLKRMLDANI STLKIAVEAD ENHPIIKMLA KDPTDSYEAA
LKDFYRRLRP GEPATLANAR STIMRLFFDP KRYNLGRVGR YKLNRKLGFP MDEESLAQVT
LRKEDVIGAL KYLIRLKMGD EKASIDDIDH LANRRVRSVG ELIQNQCRSG LARMEKIIRE
RMNLFDFSSD TLIPGKIISA KGLASVLKDF FGRSQLSQFM DQTNPVAELT HKRRLSALGP
GGLNRERAGF EVRDVHASHY GRICPIETPE GPNIGLITSL SSFAKINEFG FIETPYRIVR
DGVVTDEIEY MTADVEEECV IAQASANLDE YNMFVDPVCW ARYRGEAFEA DTSTVTHMDV
SPKQLVSIVT GLIPFLEHDD ANRALMGSNM QRQAVPLLKT EAPIVGTGLE ARAAKDSGAI
VVAEEDGVVE YVDGYKVVIA AKHHPTLKRT YDLKKFLRSN SGTCINQRPL CSVGDVVVKG
DVIADGPATD KGELALGKNI LVAFMPWYGY NFEDAIIISE KLIKQDAYTS IYIEEFELTA
RDTKLGKEEI TRDIPNVSEE VLANLGEDGI IRIGAEVKPG DILVGKITPK SETELAPEER
LLRAIFGEKA ADVKDASLTV PPGTEGVVMD VKVFSRKDRL SKSDDELVEE AVHLKDLQKG
YKNQISVLKI EYREKLGALL LNEKAPASII HRRTADILVQ EGTVFDQETI ELLEQESLVD
LLMPPCDMYD VLKSLLSDYE TSLQRLEVNY KTEVEHIREG DADLDHGVIR QVKVYVASKR
KLQVGDKMAG RHGNKGVVSK IVPEADMPYL ANGETVQMIL NPLGVPSRMN LGQVLETHLG
YAAKTAGIHV KTPVFEGFPE SRIWDMMIEQ GLPADGKSYL YDGKTGERFD NTVVIGYIYM
LKLSHLIADK IHARSIGPYS LVTQQPLGGK AQMGGQRFGE MEVWALEAYG VAHMLQEILT
VKSDDVTGRT RIYESIVKGE NLLKSGTPES FNVLIKEMQG LGLDVRPMVV DA
