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RPOB_CHLAB
ID   RPOB_CHLAB              Reviewed;        1252 AA.
AC   Q5L5I3;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN   Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=CAB661;
OS   Chlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=218497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 27085 / S26/3;
RX   PubMed=15837807; DOI=10.1101/gr.3684805;
RA   Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D.,
RA   Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D.,
RA   Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A.,
RA   Price C., Barrell B.G., Parkhill J., Longbottom D.;
RT   "The Chlamydophila abortus genome sequence reveals an array of variable
RT   proteins that contribute to interspecies variation.";
RL   Genome Res. 15:629-640(2005).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC   -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC       and 1 omega subunit. When a sigma factor is associated with the core
CC       the holoenzyme is formed, which can initiate transcription.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR   EMBL; CR848038; CAH64108.1; -; Genomic_DNA.
DR   RefSeq; WP_011097244.1; NC_004552.2.
DR   AlphaFoldDB; Q5L5I3; -.
DR   SMR; Q5L5I3; -.
DR   EnsemblBacteria; CAH64108; CAH64108; CAB661.
DR   KEGG; cab:CAB661; -.
DR   eggNOG; COG0085; Bacteria.
DR   HOGENOM; CLU_000524_4_1_0; -.
DR   OMA; FMTWEGY; -.
DR   OrthoDB; 9601at2; -.
DR   Proteomes; UP000001012; Chromosome.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00653; RNA_pol_B_RPB2; 1.
DR   Gene3D; 2.40.270.10; -; 2.
DR   Gene3D; 2.40.50.150; -; 1.
DR   Gene3D; 3.90.1110.10; -; 1.
DR   HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR   InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR   InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR   InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR   InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR   InterPro; IPR010243; RNA_pol_bsu_bac.
DR   InterPro; IPR007121; RNA_pol_bsu_CS.
DR   InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR   InterPro; IPR007642; RNA_pol_Rpb2_2.
DR   InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR   InterPro; IPR007645; RNA_pol_Rpb2_3.
DR   InterPro; IPR007641; RNA_pol_Rpb2_7.
DR   InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR   PANTHER; PTHR20856; PTHR20856; 1.
DR   Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR   Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR   Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR   Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR   Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR   Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR   TIGRFAMs; TIGR02013; rpoB; 1.
DR   PROSITE; PS01166; RNA_POL_BETA; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription;
KW   Transferase.
FT   CHAIN           1..1252
FT                   /note="DNA-directed RNA polymerase subunit beta"
FT                   /id="PRO_0000224044"
SQ   SEQUENCE   1252 AA;  140335 MW;  76077AC3D9913595 CRC64;
     MFKCPERVSV KKKEDILDLP NLIEIQIKSY KQFLQIGKLA EERDNIGLEE VFREIFPIKS
     YNEATILEYL SYNLGVPKYS PDECIRRGIT YSVTLKVRFR LTDETGIKEE EVYMGTIPIM
     TDKGTFIING AERVVVSQVH RSPGINFEQE KHSKGNILFS FRIIPYRGSW LEAIFDINDL
     IYIHIDRKKR RRKILAITFI RALGYSSDAD IIEEFFQIEE HSLKSEKDFS FLVGKILADN
     VLDEASSLVY GKAGEKLSTA MLKRMLDANI STLKIAVEAD ENHPIIKMLA KDPTDSYEAA
     LKDFYRRLRP GEPATLANAR STIMRLFFDP KRYNLGRVGR YKLNRKLGFP MDEESLAQVT
     LRKEDVIGAL KYLIRLKMGD EKASIDDIDH LANRRVRSVG ELIQNQCRSG LARMEKIIRE
     RMNLFDFSSD TLIPGKIISA KGLASVLKDF FGRSQLSQFM DQTNPVAELT HKRRLSALGP
     GGLNRERAGF EVRDVHASHY GRICPIETPE GPNIGLITSL SSFAKINEFG FIETPYRIVR
     DGVVTDEIEY MTADVEEECV IAQASANLDE YNMFVDPVCW ARYRGEAFEA DTSTVTHMDV
     SPKQLVSIVT GLIPFLEHDD ANRALMGSNM QRQAVPLLKT EAPIVGTGLE ARAAKDSGAI
     VVAEEDGVVE YVDGYKVVIA AKHHPTLKRT YDLKKFLRSN SGTCINQRPL CSVGDVVVKG
     DVIADGPATD KGELALGKNI LVAFMPWYGY NFEDAIIISE KLIKQDAYTS IYIEEFELTA
     RDTKLGKEEI TRDIPNVSEE VLANLGEDGI IRIGAEVKPG DILVGKITPK SETELAPEER
     LLRAIFGEKA ADVKDASLTV PPGTEGVVMD VKVFSRKDRL SKSDDELVEE AVHLKDLQKG
     YKNQISVLKI EYREKLGALL LNEKAPASII HRRTADILVQ EGTVFDQETI ELLEQESLVD
     LLMPPCDMYD VLKSLLSDYE TSLQRLEVNY KTEVEHIREG DADLDHGVIR QVKVYVASKR
     KLQVGDKMAG RHGNKGVVSK IVPEADMPYL ANGETVQMIL NPLGVPSRMN LGQVLETHLG
     YAAKTAGIHV KTPVFEGFPE SRIWDMMIEQ GLPADGKSYL YDGKTGERFD NTVVIGYIYM
     LKLSHLIADK IHARSIGPYS LVTQQPLGGK AQMGGQRFGE MEVWALEAYG VAHMLQEILT
     VKSDDVTGRT RIYESIVKGE NLLKSGTPES FNVLIKEMQG LGLDVRPMVV DA
 
 
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