RPOB_CHLPN
ID RPOB_CHLPN Reviewed; 1252 AA.
AC Q9Z9A0; Q9JSJ8; Q9K210;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321};
GN OrderedLocusNames=CPn_0081, CP_0694, CpB0081;
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF38502.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE001363; AAD18234.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF38502.1; ALT_INIT; Genomic_DNA.
DR EMBL; BA000008; BAA98291.1; -; Genomic_DNA.
DR EMBL; AE009440; AAP98014.1; -; Genomic_DNA.
DR PIR; A86501; A86501.
DR PIR; D72122; D72122.
DR PIR; F81548; F81548.
DR RefSeq; NP_224289.1; NC_000922.1.
DR RefSeq; WP_010882731.1; NZ_LN847257.1.
DR AlphaFoldDB; Q9Z9A0; -.
DR SMR; Q9Z9A0; -.
DR STRING; 115711.CP_0694; -.
DR PRIDE; Q9Z9A0; -.
DR EnsemblBacteria; AAD18234; AAD18234; CPn_0081.
DR EnsemblBacteria; AAF38502; AAF38502; CP_0694.
DR GeneID; 45050126; -.
DR KEGG; cpa:CP_0694; -.
DR KEGG; cpj:rpoB; -.
DR KEGG; cpn:CPn_0081; -.
DR KEGG; cpt:CpB0081; -.
DR PATRIC; fig|115713.3.peg.93; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_3_0; -.
DR Proteomes; UP000000583; Chromosome.
DR Proteomes; UP000000801; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 2.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription;
KW Transferase.
FT CHAIN 1..1252
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000047880"
FT CONFLICT 246
FT /note="S -> C (in Ref. 3; BAA98291)"
FT /evidence="ECO:0000305"
FT CONFLICT 259
FT /note="T -> I (in Ref. 3; BAA98291)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1252 AA; 140110 MW; 83939598C1F1823A CRC64;
MLKCPERVSV KKKEDIPDLP NLIEIQIKSY KQFLQIGKLA EERENIGLEE VFREIFPIKS
YNEATVLEYL SYNLGVPKYS PEECIRRGIT YSVTLKVRFR LTDETGIKEE EVYMGTIPLM
TDKGTFIING AERVVVSQVH RSPGINFEQE KHSKGNILFS FRIIPYRGSW LEAIFDINDL
IYIHIDRKKR RRKILAITFI RALGYSSDAD IIEEFFTIGE SSLRSEKDFA LLVGRILADN
IIDEASSLVY GKAGEKLSTA MLKRMLDAGI ASVKIAVDAD ENHPIIKMLA KDPTDSYEAA
LKDFYRRLRP GEPATLANAR STIMRLFFDP KRYNLGRVGR YKLNRKLGFS IDDEALSQVT
LRKEDVIGAL KYLIRLKMGD EKACVDDIDH LANRRVRSVG ELIQNQCRSG LARMEKIVRE
RMNLFDFSSD TLTPGKVVSA KGLASVLKDF FGRSQLSQFM DQTNPVAELT HKRRLSALGP
GGLNRERAGF EVRDVHASHY GRICPIETPE GPNIGLITSL SSFAKINEFG FIETPYRIVR
DGIVTDEIEY MTADVEEECV IAQASASLDE YNMFTEPVCW VRYAGEAFEA DTSTVTHMDV
SPKQLVSIVT GLIPFLEHDD ANRALMGSNM QRQAVPLLKT EAPVVGTGLE CRAAKDSGAI
VVAEEDGVVD FVDGYKVVVA AKHNPTIKRT YHLKKFLRSN SGTCINQQPL CAVGDVITKG
DVIADGPATD RGELALGKNV LVAFMPWYGY NFEDAIIISE KLIREDAYTS IYIEEFELTA
RDTKLGKEEI TRDIPNVSDE VLANLGEDGI IRIGAEVKPG DILVGKITPK SETELAPEER
LLRAIFGEKA ADVKDASLTV PPGTEGVVMD VKVFSRKDRL SKSDDELVEE AVHLKDLQKG
YKNQVATLKT EYREKLGALL LNEKAPAAII HRRTAEIVVH EGLLFDQETI ERIEQEDLVD
LLMPNCEMYE VLKGLLSDYE TALQRLEINY KTEVEHIREG DADLDHGVIR QVKVYVASKR
KLQVGDKMAG RHGNKGVVSK IVPEADMPYL SNGETVQMIL NPLGVPSRMN LGQVLETHLG
YAAKTAGIYV KTPVFEGFPE QRIWDMMIEQ GLPEDGKSFL YDGKTGERFD NKVVIGYIYM
LKLSHLIADK IHARSIGPYS LVTQQPLGGK AQMGGQRFGE MEVWALEAYG VAHMLQEILT
VKSDDVSGRT RIYESIVKGE NLLRSGTPES FNVLIKEMQG LGLDVRPMVV DA
