ATRAP_HUMAN
ID ATRAP_HUMAN Reviewed; 159 AA.
AC Q6RW13; A8MVQ5; Q5SNV4; Q5SNV5; Q96AC0; Q96PL4; Q9NRW9;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Type-1 angiotensin II receptor-associated protein;
DE AltName: Full=AT1 receptor-associated protein;
GN Name=AGTRAP; Synonyms=ATRAP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND INTERACTION
RP WITH RACK1 AND AGTR1.
RC TISSUE=Fetal brain;
RX PubMed=11733189; DOI=10.1016/s1357-2725(01)00094-2;
RA Wang W., Huang Y., Zhou Z., Tang R., Zhao W., Zeng L., Xu M., Cheng C.,
RA Gu S., Ying K., Xie Y., Mao Y.;
RT "Identification and characterization of AGTRAP, a human homolog of murine
RT angiotensin II receptor-associated protein (Agtrap).";
RL Int. J. Biochem. Cell Biol. 34:93-102(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Kidney;
RA Ye R.D., He R.;
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Pancreas islet cell;
RA Melton D., Brown J., Kenty G., Permutt A., Lee C., Kaestner K.,
RA Lemishka I., Scearce M., Brestelli J., Gradwohl G., Clifton S., Hillier L.,
RA Marra M., Pape D., Wylie T., Martin J., Blistain A., Schmitt A.,
RA Theising B., Ritter E., Ronko I., Bennett J., Cardenas M., Gibbons M.,
RA McCann R., Cole R., Tsagareishvili R., Williams T., Jackson Y., Bowers Y.;
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT VAL-143.
RG SeattleSNPs variation discovery resource;
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5).
RC TISSUE=Colon, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH AGTR1.
RX PubMed=12960423; DOI=10.1091/mbc.e03-06-0383;
RA Lopez-Ilasaca M., Liu X., Tamura K., Dzau V.J.;
RT "The angiotensin II type I receptor-associated protein, ATRAP, is a
RT transmembrane protein and a modulator of angiotensin II signaling.";
RL Mol. Biol. Cell 14:5038-5050(2003).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126; SER-127; THR-135;
RP SER-138 AND SER-153, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- FUNCTION: Appears to be a negative regulator of type-1 angiotensin II
CC receptor-mediated signaling by regulating receptor internalization as
CC well as mechanism of receptor desensitization such as phosphorylation.
CC Induces also a decrease in cell proliferation and angiotensin II-
CC stimulated transcriptional activity. {ECO:0000269|PubMed:12960423}.
CC -!- SUBUNIT: Interacts with RACK1, and with the C-terminal region of AGTR1.
CC {ECO:0000269|PubMed:11733189, ECO:0000269|PubMed:12960423}.
CC -!- INTERACTION:
CC Q6RW13; Q96CM8: ACSF2; NbExp=4; IntAct=EBI-741181, EBI-2876502;
CC Q6RW13; P54886: ALDH18A1; NbExp=3; IntAct=EBI-741181, EBI-1210304;
CC Q6RW13; Q9Y2T2: AP3M1; NbExp=3; IntAct=EBI-741181, EBI-2371151;
CC Q6RW13; Q96II5: ARAF; NbExp=3; IntAct=EBI-741181, EBI-9383168;
CC Q6RW13; P53365: ARFIP2; NbExp=4; IntAct=EBI-741181, EBI-638194;
CC Q6RW13; Q96DR5: BPIFA2; NbExp=3; IntAct=EBI-741181, EBI-10284754;
CC Q6RW13; P04632: CAPNS1; NbExp=3; IntAct=EBI-741181, EBI-711828;
CC Q6RW13; O95971: CD160; NbExp=3; IntAct=EBI-741181, EBI-4314390;
CC Q6RW13; Q8NI60: COQ8A; NbExp=4; IntAct=EBI-741181, EBI-745535;
CC Q6RW13; Q9UGL9: CRCT1; NbExp=3; IntAct=EBI-741181, EBI-713677;
CC Q6RW13; Q9BW61: DDA1; NbExp=3; IntAct=EBI-741181, EBI-2510241;
CC Q6RW13; Q8NHQ9: DDX55; NbExp=3; IntAct=EBI-741181, EBI-5459844;
CC Q6RW13; Q5VYK3: ECPAS; NbExp=3; IntAct=EBI-741181, EBI-521451;
CC Q6RW13; Q8IWE2: FAM114A1; NbExp=3; IntAct=EBI-741181, EBI-2686288;
CC Q6RW13; O95363: FARS2; NbExp=3; IntAct=EBI-741181, EBI-2513774;
CC Q6RW13; Q14CZ7: FASTKD3; NbExp=3; IntAct=EBI-741181, EBI-10234819;
CC Q6RW13; Q969F0: FATE1; NbExp=3; IntAct=EBI-741181, EBI-743099;
CC Q6RW13; Q8N612: FHIP1B; NbExp=3; IntAct=EBI-741181, EBI-742137;
CC Q6RW13; P60520: GABARAPL2; NbExp=3; IntAct=EBI-741181, EBI-720116;
CC Q6RW13; Q8IVA8: GAD1; NbExp=3; IntAct=EBI-741181, EBI-10209663;
CC Q6RW13; Q99259: GAD1; NbExp=3; IntAct=EBI-741181, EBI-743184;
CC Q6RW13; Q05329: GAD2; NbExp=3; IntAct=EBI-741181, EBI-9304251;
CC Q6RW13; P39905: GDNF; NbExp=3; IntAct=EBI-741181, EBI-10207709;
CC Q6RW13; Q12789: GTF3C1; NbExp=3; IntAct=EBI-741181, EBI-357956;
CC Q6RW13; Q99525: H4C7; NbExp=3; IntAct=EBI-741181, EBI-10294329;
CC Q6RW13; P49590: HARS2; NbExp=3; IntAct=EBI-741181, EBI-3909030;
CC Q6RW13; P09429: HMGB1; NbExp=3; IntAct=EBI-741181, EBI-389432;
CC Q6RW13; Q8IWL3: HSCB; NbExp=4; IntAct=EBI-741181, EBI-1805738;
CC Q6RW13; P34932: HSPA4; NbExp=3; IntAct=EBI-741181, EBI-356933;
CC Q6RW13; Q9H1K1: ISCU; NbExp=3; IntAct=EBI-741181, EBI-1047335;
CC Q6RW13; P25791: LMO2; NbExp=3; IntAct=EBI-741181, EBI-739696;
CC Q6RW13; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-741181, EBI-739832;
CC Q6RW13; Q96PE7: MCEE; NbExp=4; IntAct=EBI-741181, EBI-10292326;
CC Q6RW13; Q9NQG6: MIEF1; NbExp=3; IntAct=EBI-741181, EBI-740987;
CC Q6RW13; Q96C03: MIEF2; NbExp=3; IntAct=EBI-741181, EBI-750153;
CC Q6RW13; Q6IN84: MRM1; NbExp=3; IntAct=EBI-741181, EBI-5454865;
CC Q6RW13; Q96E29: MTERF3; NbExp=3; IntAct=EBI-741181, EBI-7825321;
CC Q6RW13; Q9UIF7-3: MUTYH; NbExp=3; IntAct=EBI-741181, EBI-10321956;
CC Q6RW13; Q9HB07: MYG1; NbExp=4; IntAct=EBI-741181, EBI-709754;
CC Q6RW13; Q9ULP0: NDRG4; NbExp=3; IntAct=EBI-741181, EBI-10323810;
CC Q6RW13; Q9UMS0: NFU1; NbExp=3; IntAct=EBI-741181, EBI-725252;
CC Q6RW13; P25208: NFYB; NbExp=3; IntAct=EBI-741181, EBI-389728;
CC Q6RW13; Q16617: NKG7; NbExp=3; IntAct=EBI-741181, EBI-3919611;
CC Q6RW13; Q5JS98: PBX3; NbExp=3; IntAct=EBI-741181, EBI-10244393;
CC Q6RW13; Q96AL5: PBX3; NbExp=3; IntAct=EBI-741181, EBI-741171;
CC Q6RW13; Q9UKL6: PCTP; NbExp=3; IntAct=EBI-741181, EBI-4402391;
CC Q6RW13; O00330: PDHX; NbExp=5; IntAct=EBI-741181, EBI-751566;
CC Q6RW13; Q9BSJ6: PIMREG; NbExp=3; IntAct=EBI-741181, EBI-2568609;
CC Q6RW13; Q9UKF7: PITPNC1; NbExp=6; IntAct=EBI-741181, EBI-749241;
CC Q6RW13; P43378: PTPN9; NbExp=5; IntAct=EBI-741181, EBI-742898;
CC Q6RW13; Q6IQ43: PTPN9; NbExp=3; IntAct=EBI-741181, EBI-10250413;
CC Q6RW13; Q96LZ7: RMDN2; NbExp=3; IntAct=EBI-741181, EBI-2806908;
CC Q6RW13; Q9HC62: SENP2; NbExp=3; IntAct=EBI-741181, EBI-714881;
CC Q6RW13; Q13596: SNX1; NbExp=3; IntAct=EBI-741181, EBI-2822329;
CC Q6RW13; Q9NZD8: SPG21; NbExp=5; IntAct=EBI-741181, EBI-742688;
CC Q6RW13; Q99909: SSX3; NbExp=3; IntAct=EBI-741181, EBI-10295431;
CC Q6RW13; O60225: SSX5; NbExp=5; IntAct=EBI-741181, EBI-10186198;
CC Q6RW13; Q7L1H2: STAG3L1; NbExp=3; IntAct=EBI-741181, EBI-10255998;
CC Q6RW13; E5KS60: SUCLA2; NbExp=3; IntAct=EBI-741181, EBI-10176959;
CC Q6RW13; Q17RD7: SYT16; NbExp=5; IntAct=EBI-741181, EBI-10238936;
CC Q6RW13; Q969Z0: TBRG4; NbExp=3; IntAct=EBI-741181, EBI-702328;
CC Q6RW13; Q96MN5: TCEANC2; NbExp=3; IntAct=EBI-741181, EBI-5462748;
CC Q6RW13; Q00059: TFAM; NbExp=3; IntAct=EBI-741181, EBI-1049924;
CC Q6RW13; Q96J77: TPD52L3; NbExp=3; IntAct=EBI-741181, EBI-932162;
CC Q6RW13; P68363: TUBA1B; NbExp=3; IntAct=EBI-741181, EBI-487083;
CC Q6RW13; Q99757: TXN2; NbExp=3; IntAct=EBI-741181, EBI-2932492;
CC Q6RW13; Q9BQ24: ZFYVE21; NbExp=3; IntAct=EBI-741181, EBI-2849569;
CC Q6RW13-2; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-11522760, EBI-11522760;
CC Q6RW13-2; Q68DC2: ANKS6; NbExp=3; IntAct=EBI-11522760, EBI-7054139;
CC Q6RW13-2; Q9Y2T2: AP3M1; NbExp=3; IntAct=EBI-11522760, EBI-2371151;
CC Q6RW13-2; P06727: APOA4; NbExp=3; IntAct=EBI-11522760, EBI-1222447;
CC Q6RW13-2; Q13520: AQP6; NbExp=3; IntAct=EBI-11522760, EBI-13059134;
CC Q6RW13-2; P53365: ARFIP2; NbExp=3; IntAct=EBI-11522760, EBI-638194;
CC Q6RW13-2; P56381: ATP5F1E; NbExp=3; IntAct=EBI-11522760, EBI-3904845;
CC Q6RW13-2; Q9BXK5: BCL2L13; NbExp=3; IntAct=EBI-11522760, EBI-747430;
CC Q6RW13-2; Q96DR5: BPIFA2; NbExp=3; IntAct=EBI-11522760, EBI-10284754;
CC Q6RW13-2; Q6NSX1: CCDC70; NbExp=3; IntAct=EBI-11522760, EBI-6873045;
CC Q6RW13-2; P11912: CD79A; NbExp=3; IntAct=EBI-11522760, EBI-7797864;
CC Q6RW13-2; P09093: CELA3A; NbExp=3; IntAct=EBI-11522760, EBI-8646391;
CC Q6RW13-2; Q8NI60: COQ8A; NbExp=6; IntAct=EBI-11522760, EBI-745535;
CC Q6RW13-2; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-11522760, EBI-18013275;
CC Q6RW13-2; P00387: CYB5R3; NbExp=3; IntAct=EBI-11522760, EBI-1046040;
CC Q6RW13-2; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-11522760, EBI-2680384;
CC Q6RW13-2; Q9NR28: DIABLO; NbExp=6; IntAct=EBI-11522760, EBI-517508;
CC Q6RW13-2; Q96KC8: DNAJC1; NbExp=3; IntAct=EBI-11522760, EBI-296550;
CC Q6RW13-2; Q5VYK3: ECPAS; NbExp=3; IntAct=EBI-11522760, EBI-521451;
CC Q6RW13-2; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-11522760, EBI-781551;
CC Q6RW13-2; Q6IPR1: ETFRF1; NbExp=3; IntAct=EBI-11522760, EBI-12292149;
CC Q6RW13-2; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-11522760, EBI-18304435;
CC Q6RW13-2; O95363: FARS2; NbExp=3; IntAct=EBI-11522760, EBI-2513774;
CC Q6RW13-2; Q969F0: FATE1; NbExp=3; IntAct=EBI-11522760, EBI-743099;
CC Q6RW13-2; O15552: FFAR2; NbExp=3; IntAct=EBI-11522760, EBI-2833872;
CC Q6RW13-2; A0A0S2Z3E9: FGA; NbExp=3; IntAct=EBI-11522760, EBI-16439102;
CC Q6RW13-2; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-11522760, EBI-12142257;
CC Q6RW13-2; A0A0S2Z4D9: GAD1; NbExp=3; IntAct=EBI-11522760, EBI-16430771;
CC Q6RW13-2; Q99259: GAD1; NbExp=6; IntAct=EBI-11522760, EBI-743184;
CC Q6RW13-2; Q05329: GAD2; NbExp=3; IntAct=EBI-11522760, EBI-9304251;
CC Q6RW13-2; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-11522760, EBI-13345167;
CC Q6RW13-2; Q8TED1: GPX8; NbExp=3; IntAct=EBI-11522760, EBI-11721746;
CC Q6RW13-2; P32780: GTF2H1; NbExp=3; IntAct=EBI-11522760, EBI-715539;
CC Q6RW13-2; P31937: HIBADH; NbExp=3; IntAct=EBI-11522760, EBI-11427100;
CC Q6RW13-2; C9JCN9: HSBP1L1; NbExp=3; IntAct=EBI-11522760, EBI-2685549;
CC Q6RW13-2; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-11522760, EBI-18053395;
CC Q6RW13-2; Q9UBD0: HSFX2; NbExp=3; IntAct=EBI-11522760, EBI-947253;
CC Q6RW13-2; P16871: IL7R; NbExp=3; IntAct=EBI-11522760, EBI-80490;
CC Q6RW13-2; O95279: KCNK5; NbExp=3; IntAct=EBI-11522760, EBI-3934936;
CC Q6RW13-2; P43628: KIR2DL3; NbExp=3; IntAct=EBI-11522760, EBI-8632435;
CC Q6RW13-2; Q8N743: KIR3DL3; NbExp=3; IntAct=EBI-11522760, EBI-17272405;
CC Q6RW13-2; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-11522760, EBI-739832;
CC Q6RW13-2; Q9HCJ2: LRRC4C; NbExp=3; IntAct=EBI-11522760, EBI-3925442;
CC Q6RW13-2; Q96AG4: LRRC59; NbExp=3; IntAct=EBI-11522760, EBI-358888;
CC Q6RW13-2; Q96PE7: MCEE; NbExp=6; IntAct=EBI-11522760, EBI-10292326;
CC Q6RW13-2; O14880: MGST3; NbExp=3; IntAct=EBI-11522760, EBI-724754;
CC Q6RW13-2; Q9NQG6: MIEF1; NbExp=3; IntAct=EBI-11522760, EBI-740987;
CC Q6RW13-2; Q96C03-3: MIEF2; NbExp=3; IntAct=EBI-11522760, EBI-11988931;
CC Q6RW13-2; Q15546: MMD; NbExp=3; IntAct=EBI-11522760, EBI-17873222;
CC Q6RW13-2; Q6IN84: MRM1; NbExp=3; IntAct=EBI-11522760, EBI-5454865;
CC Q6RW13-2; Q9Y3B7: MRPL11; NbExp=3; IntAct=EBI-11522760, EBI-5453723;
CC Q6RW13-2; Q96E11: MRRF; NbExp=3; IntAct=EBI-11522760, EBI-2855755;
CC Q6RW13-2; Q96E29: MTERF3; NbExp=3; IntAct=EBI-11522760, EBI-7825321;
CC Q6RW13-2; Q9HB07: MYG1; NbExp=3; IntAct=EBI-11522760, EBI-709754;
CC Q6RW13-2; Q9ULP0-2: NDRG4; NbExp=6; IntAct=EBI-11522760, EBI-11978907;
CC Q6RW13-2; Q9BU61: NDUFAF3; NbExp=3; IntAct=EBI-11522760, EBI-2114801;
CC Q6RW13-2; Q16617: NKG7; NbExp=3; IntAct=EBI-11522760, EBI-3919611;
CC Q6RW13-2; Q96AL5: PBX3; NbExp=3; IntAct=EBI-11522760, EBI-741171;
CC Q6RW13-2; P49585: PCYT1A; NbExp=3; IntAct=EBI-11522760, EBI-2563309;
CC Q6RW13-2; Q9BSJ6: PIMREG; NbExp=3; IntAct=EBI-11522760, EBI-2568609;
CC Q6RW13-2; Q9UKF7-2: PITPNC1; NbExp=3; IntAct=EBI-11522760, EBI-14223623;
CC Q6RW13-2; Q9NVS9: PNPO; NbExp=6; IntAct=EBI-11522760, EBI-11030787;
CC Q6RW13-2; Q9Y2S7: POLDIP2; NbExp=3; IntAct=EBI-11522760, EBI-713000;
CC Q6RW13-2; P30405: PPIF; NbExp=3; IntAct=EBI-11522760, EBI-5544229;
CC Q6RW13-2; Q99633: PRPF18; NbExp=3; IntAct=EBI-11522760, EBI-2798416;
CC Q6RW13-2; P43378: PTPN9; NbExp=3; IntAct=EBI-11522760, EBI-742898;
CC Q6RW13-2; Q15771: RAB30; NbExp=3; IntAct=EBI-11522760, EBI-3924277;
CC Q6RW13-2; Q8N0V3: RBFA; NbExp=3; IntAct=EBI-11522760, EBI-3232108;
CC Q6RW13-2; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-11522760, EBI-10192441;
CC Q6RW13-2; Q96LZ7: RMDN2; NbExp=3; IntAct=EBI-11522760, EBI-2806908;
CC Q6RW13-2; A8MRB1: S100B; NbExp=3; IntAct=EBI-11522760, EBI-16432654;
CC Q6RW13-2; P57086: SCAND1; NbExp=3; IntAct=EBI-11522760, EBI-745846;
CC Q6RW13-2; Q9HC62: SENP2; NbExp=3; IntAct=EBI-11522760, EBI-714881;
CC Q6RW13-2; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-11522760, EBI-2623095;
CC Q6RW13-2; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-11522760, EBI-17595455;
CC Q6RW13-2; Q8TBB6: SLC7A14; NbExp=3; IntAct=EBI-11522760, EBI-5235586;
CC Q6RW13-2; Q9H0W8: SMG9; NbExp=3; IntAct=EBI-11522760, EBI-2872322;
CC Q6RW13-2; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-11522760, EBI-742688;
CC Q6RW13-2; O60225-2: SSX5; NbExp=3; IntAct=EBI-11522760, EBI-12033476;
CC Q6RW13-2; P49675: STAR; NbExp=3; IntAct=EBI-11522760, EBI-722932;
CC Q6RW13-2; Q96DR4: STARD4; NbExp=3; IntAct=EBI-11522760, EBI-17217258;
CC Q6RW13-2; Q9H169-2: STMN4; NbExp=3; IntAct=EBI-11522760, EBI-20117546;
CC Q6RW13-2; Q16623: STX1A; NbExp=3; IntAct=EBI-11522760, EBI-712466;
CC Q6RW13-2; Q9P2R7: SUCLA2; NbExp=6; IntAct=EBI-11522760, EBI-2269898;
CC Q6RW13-2; Q17RD7: SYT16; NbExp=3; IntAct=EBI-11522760, EBI-10238936;
CC Q6RW13-2; Q969Z0: TBRG4; NbExp=3; IntAct=EBI-11522760, EBI-702328;
CC Q6RW13-2; Q15560: TCEA2; NbExp=3; IntAct=EBI-11522760, EBI-710310;
CC Q6RW13-2; Q00059: TFAM; NbExp=3; IntAct=EBI-11522760, EBI-1049924;
CC Q6RW13-2; Q8WY91: THAP4; NbExp=3; IntAct=EBI-11522760, EBI-726691;
CC Q6RW13-2; Q8IV31: TMEM139; NbExp=3; IntAct=EBI-11522760, EBI-7238458;
CC Q6RW13-2; Q6ZT21: TMPPE; NbExp=3; IntAct=EBI-11522760, EBI-11724433;
CC Q6RW13-2; P49638: TTPA; NbExp=3; IntAct=EBI-11522760, EBI-10210710;
CC Q6RW13-2; Q99757: TXN2; NbExp=3; IntAct=EBI-11522760, EBI-2932492;
CC Q6RW13-2; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-11522760, EBI-10180829;
CC Q6RW13-2; Q9Y2Z4: YARS2; NbExp=3; IntAct=EBI-11522760, EBI-1049286;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:12960423}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:12960423}. Golgi apparatus membrane
CC {ECO:0000269|PubMed:12960423}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:12960423}. Cytoplasmic vesicle membrane
CC {ECO:0000269|PubMed:12960423}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:12960423}. Note=Present in perinuclear vesicular
CC membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q6RW13-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6RW13-2; Sequence=VSP_014839;
CC Name=3;
CC IsoId=Q6RW13-3; Sequence=VSP_039290;
CC Name=5;
CC IsoId=Q6RW13-5; Sequence=VSP_040406;
CC Name=4;
CC IsoId=Q6RW13-4; Sequence=VSP_039291;
CC -!- TISSUE SPECIFICITY: Ubiquitous but more abundant in kidney, heart,
CC pancreas and thyroid. {ECO:0000269|PubMed:11733189}.
CC -!- WEB RESOURCE: Name=SeattleSNPs;
CC URL="http://pga.gs.washington.edu/data/agtrap/";
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DR EMBL; AF312374; AAL26806.1; -; mRNA.
DR EMBL; AF165187; AAF89547.1; -; mRNA.
DR EMBL; CA866314; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AY488088; AAR25556.1; -; Genomic_DNA.
DR EMBL; AL953897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471130; EAW71702.1; -; Genomic_DNA.
DR EMBL; BC017328; AAH17328.1; -; mRNA.
DR EMBL; BE782705; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS136.1; -. [Q6RW13-1]
DR CCDS; CCDS30585.1; -. [Q6RW13-2]
DR CCDS; CCDS30586.1; -. [Q6RW13-4]
DR CCDS; CCDS41248.1; -. [Q6RW13-3]
DR CCDS; CCDS44056.1; -. [Q6RW13-5]
DR RefSeq; NP_001035284.1; NM_001040194.1. [Q6RW13-2]
DR RefSeq; NP_001035285.1; NM_001040195.1. [Q6RW13-4]
DR RefSeq; NP_001035286.1; NM_001040196.1. [Q6RW13-5]
DR RefSeq; NP_001035287.1; NM_001040197.1. [Q6RW13-3]
DR RefSeq; NP_065083.3; NM_020350.4. [Q6RW13-1]
DR AlphaFoldDB; Q6RW13; -.
DR SMR; Q6RW13; -.
DR BioGRID; 121356; 174.
DR IntAct; Q6RW13; 146.
DR MINT; Q6RW13; -.
DR STRING; 9606.ENSP00000319713; -.
DR iPTMnet; Q6RW13; -.
DR PhosphoSitePlus; Q6RW13; -.
DR SwissPalm; Q6RW13; -.
DR BioMuta; AGTRAP; -.
DR DMDM; 71152303; -.
DR EPD; Q6RW13; -.
DR jPOST; Q6RW13; -.
DR MassIVE; Q6RW13; -.
DR MaxQB; Q6RW13; -.
DR PaxDb; Q6RW13; -.
DR PeptideAtlas; Q6RW13; -.
DR PRIDE; Q6RW13; -.
DR ProteomicsDB; 67329; -. [Q6RW13-1]
DR ProteomicsDB; 67330; -. [Q6RW13-2]
DR ProteomicsDB; 67331; -. [Q6RW13-3]
DR ProteomicsDB; 67332; -. [Q6RW13-4]
DR ProteomicsDB; 67333; -. [Q6RW13-5]
DR TopDownProteomics; Q6RW13-1; -. [Q6RW13-1]
DR TopDownProteomics; Q6RW13-2; -. [Q6RW13-2]
DR Antibodypedia; 28197; 237 antibodies from 27 providers.
DR DNASU; 57085; -.
DR Ensembl; ENST00000314340.10; ENSP00000319713.5; ENSG00000177674.16. [Q6RW13-1]
DR Ensembl; ENST00000376629.8; ENSP00000365816.4; ENSG00000177674.16. [Q6RW13-2]
DR Ensembl; ENST00000376637.7; ENSP00000365824.3; ENSG00000177674.16. [Q6RW13-4]
DR Ensembl; ENST00000400895.6; ENSP00000383688.2; ENSG00000177674.16. [Q6RW13-3]
DR Ensembl; ENST00000452018.6; ENSP00000408505.2; ENSG00000177674.16. [Q6RW13-5]
DR GeneID; 57085; -.
DR KEGG; hsa:57085; -.
DR MANE-Select; ENST00000314340.10; ENSP00000319713.5; NM_020350.5; NP_065083.3.
DR UCSC; uc001ast.4; human. [Q6RW13-1]
DR CTD; 57085; -.
DR DisGeNET; 57085; -.
DR GeneCards; AGTRAP; -.
DR HGNC; HGNC:13539; AGTRAP.
DR HPA; ENSG00000177674; Low tissue specificity.
DR MIM; 608729; gene.
DR neXtProt; NX_Q6RW13; -.
DR OpenTargets; ENSG00000177674; -.
DR PharmGKB; PA38363; -.
DR VEuPathDB; HostDB:ENSG00000177674; -.
DR eggNOG; ENOG502S36M; Eukaryota.
DR GeneTree; ENSGT00390000017402; -.
DR HOGENOM; CLU_148105_0_0_1; -.
DR InParanoid; Q6RW13; -.
DR OMA; NINFGFP; -.
DR OrthoDB; 1325275at2759; -.
DR PhylomeDB; Q6RW13; -.
DR TreeFam; TF324477; -.
DR PathwayCommons; Q6RW13; -.
DR Reactome; R-HSA-6802952; Signaling by BRAF and RAF1 fusions.
DR SignaLink; Q6RW13; -.
DR BioGRID-ORCS; 57085; 10 hits in 1080 CRISPR screens.
DR ChiTaRS; AGTRAP; human.
DR GeneWiki; AGTRAP; -.
DR GenomeRNAi; 57085; -.
DR Pharos; Q6RW13; Tbio.
DR PRO; PR:Q6RW13; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q6RW13; protein.
DR Bgee; ENSG00000177674; Expressed in granulocyte and 174 other tissues.
DR ExpressionAtlas; Q6RW13; baseline and differential.
DR Genevisible; Q6RW13; HS.
DR GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004945; F:angiotensin type II receptor activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0008217; P:regulation of blood pressure; IBA:GO_Central.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR InterPro; IPR009436; AGTRAP.
DR PANTHER; PTHR16521; PTHR16521; 1.
DR Pfam; PF06396; AGTRAP; 1.
DR SMART; SM00805; AGTRAP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasmic vesicle; Endoplasmic reticulum;
KW Golgi apparatus; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..159
FT /note="Type-1 angiotensin II receptor-associated protein"
FT /id="PRO_0000064735"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..86
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 110..122
FT /note="Interaction with AGTR1"
FT REGION 140..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 126
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 127
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 135
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 138
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 153
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 10..159
FT /note="VILLGHWLLTTWGCIVFSGSYAWANFTILALGVWAVAQRDSIDAISMFLGGL
FT LATIFLDIVHISIFYPRVSLTDTGRFGVGMAILSLLLKPLSCCFVYHMYRERGGELLVH
FT TGFLGSSQDRSAYQTIDSAEAPADPFAVPEGRSQDARGY -> GLHCILRLLCLGQLHH
FT PGLGRVGCGSAGLHRRHKHVSGWLAGHHLPGHRAHQHLLPAGQPHGHGPLWRGHGHPQL
FT AAQAALLLLRLPHVPGARGFPWVFSGP (in isoform 4)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_039291"
FT VAR_SEQ 21..159
FT /note="WGCIVFSGSYAWANFTILALGVWAVAQRDSIDAISMFLGGLLATIFLDIVHI
FT SIFYPRVSLTDTGRFGVGMAILSLLLKPLSCCFVYHMYRERGGELLVHTGFLGSSQDRS
FT AYQTIDSAEAPADPFAVPEGRSQDARGY -> CFWRHFSAKPRLETIELTCALCKLRSA
FT AHRATAGLHCILRLLCLGQLHHPGLGRVGCGSAGLHRRHKHVSGWLAGHHLPGHRAHQH
FT LLPAGQPHGHGPLWRGHGHPQLAAQAALLLLRLPHVPGARG (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_039290"
FT VAR_SEQ 21..159
FT /note="WGCIVFSGSYAWANFTILALGVWAVAQRDSIDAISMFLGGLLATIFLDIVHI
FT SIFYPRVSLTDTGRFGVGMAILSLLLKPLSCCFVYHMYRERGGELLVHTGFLGSSQDRS
FT AYQTIDSAEAPADPFAVPEGRSQDARGY -> CFWRHFSAKPRLETIELTCALCKLRSA
FT AHRATAGLHCILRLLCLGQLHHPGLGRVGCGSAGLHRRHKHVSGWLAGHHLPGHRAHQH
FT LLPAGQPHGHGPLWRGHGHPQLAAQAALLLLRLPHVPGARGFPWVFSGP (in
FT isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040406"
FT VAR_SEQ 115..121
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_014839"
FT VARIANT 143
FT /note="A -> V (in dbSNP:rs17875960)"
FT /evidence="ECO:0000269|Ref.4"
FT /id="VAR_023075"
FT CONFLICT 158
FT /note="G -> R (in Ref. 2; AAF89547)"
FT /evidence="ECO:0000305"
FT CONFLICT 159
FT /note="Y -> S (in Ref. 1; AAL26806)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 159 AA; 17419 MW; 7E1D5C7E79AE6BC5 CRC64;
MELPAVNLKV ILLGHWLLTT WGCIVFSGSY AWANFTILAL GVWAVAQRDS IDAISMFLGG
LLATIFLDIV HISIFYPRVS LTDTGRFGVG MAILSLLLKP LSCCFVYHMY RERGGELLVH
TGFLGSSQDR SAYQTIDSAE APADPFAVPE GRSQDARGY
