ATRAP_RAT
ID ATRAP_RAT Reviewed; 160 AA.
AC Q642A2;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Type-1 angiotensin II receptor-associated protein;
DE AltName: Full=AT1 receptor-associated protein;
GN Name=Agtrap; Synonyms=Atrap;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP FUNCTION.
RX PubMed=11162453; DOI=10.1006/bbrc.2000.4055;
RA Cui T., Nakagami H., Iwai M., Takeda Y., Shiuchi T., Tamura K., Daviet L.,
RA Horiuchi M.;
RT "ATRAP, novel AT1 receptor associated protein, enhances internalization of
RT AT1 receptor and inhibits vascular smooth muscle cell growth.";
RL Biochem. Biophys. Res. Commun. 279:938-941(2000).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Appears to be a negative regulator of type-1 angiotensin II
CC receptor-mediated signaling by regulating receptor internalization as
CC well as mechanism of receptor desensitization such as phosphorylation.
CC May play a role of negative regulator in cardiomyocyte hypertrophy
CC induced by angiotensin II through an inhibition of p38 mitogen-
CC activated protein kinase pathway. Attenuates type-1 angiotensin II
CC receptor growth promoting effect and angiotensin II-induced
CC phosphorylation of protein kinase AKT and of STAT3.
CC {ECO:0000269|PubMed:11162453}.
CC -!- SUBUNIT: Interacts with RACK1, and with the carboxy-terminal region of
CC AGTR1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic
CC vesicle membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Present in perinuclear vesicular membranes,
CC Endoplasmic reticulum, Golgi and endocytic vesicles. {ECO:0000250}.
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DR EMBL; BC082019; AAH82019.1; -; mRNA.
DR RefSeq; NP_001007655.1; NM_001007654.1.
DR AlphaFoldDB; Q642A2; -.
DR STRING; 10116.ENSRNOP00000011747; -.
DR PaxDb; Q642A2; -.
DR Ensembl; ENSRNOT00000011747; ENSRNOP00000011747; ENSRNOG00000008619.
DR GeneID; 298646; -.
DR KEGG; rno:298646; -.
DR CTD; 57085; -.
DR RGD; 1359346; Agtrap.
DR eggNOG; ENOG502S36M; Eukaryota.
DR GeneTree; ENSGT00390000017402; -.
DR HOGENOM; CLU_126745_0_0_1; -.
DR InParanoid; Q642A2; -.
DR OMA; NINFGFP; -.
DR OrthoDB; 1325275at2759; -.
DR PhylomeDB; Q642A2; -.
DR TreeFam; TF324477; -.
DR PRO; PR:Q642A2; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000008619; Expressed in adult mammalian kidney and 19 other tissues.
DR Genevisible; Q642A2; RN.
DR GO; GO:0005938; C:cell cortex; ISO:RGD.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0004945; F:angiotensin type II receptor activity; ISO:RGD.
DR GO; GO:0008217; P:regulation of blood pressure; ISO:RGD.
DR GO; GO:0001666; P:response to hypoxia; IEP:RGD.
DR InterPro; IPR009436; AGTRAP.
DR PANTHER; PTHR16521; PTHR16521; 1.
DR Pfam; PF06396; AGTRAP; 1.
DR SMART; SM00805; AGTRAP; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; Endoplasmic reticulum; Golgi apparatus; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..160
FT /note="Type-1 angiotensin II receptor-associated protein"
FT /id="PRO_0000064738"
FT TOPO_DOM 1..9
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..53
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..86
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..160
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 110..122
FT /note="Interaction with AGTR1"
FT /evidence="ECO:0000250"
FT REGION 128..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 127
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6RW13"
FT MOD_RES 135
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6RW13"
FT MOD_RES 138
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6RW13"
SQ SEQUENCE 160 AA; 17398 MW; DEBD34E6F62CBB5A CRC64;
MELPAVNLKV ILLVHWLLTT WGCLAFSGSY AWGNFTILAL GVWAVAQRDS VDAIGMFLGG
LVATIFLDII YISIFYSSVA VGDTGRFSAG MAIFSLLLKP FSCCLVYHMH RERGGELPLR
SDFFGPSQEH SAYQTIDSSD SPADPLASLE NKGQAAPRGY
