RPOB_CORJK
ID RPOB_CORJK Reviewed; 1164 AA.
AC Q4JT32;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=jk1846;
OS Corynebacterium jeikeium (strain K411).
OC Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC Corynebacterium.
OX NCBI_TaxID=306537;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K411;
RX PubMed=15968079; DOI=10.1128/jb.187.13.4671-4682.2005;
RA Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A.,
RA Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F.,
RA Rupp O., Schneiker S., Viehoever P., Puehler A.;
RT "Complete genome sequence and analysis of the multiresistant nosocomial
RT pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the
RT human skin flora.";
RL J. Bacteriol. 187:4671-4682(2005).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; CR931997; CAI38025.1; -; Genomic_DNA.
DR AlphaFoldDB; Q4JT32; -.
DR SMR; Q4JT32; -.
DR STRING; 306537.jk1846; -.
DR EnsemblBacteria; CAI38025; CAI38025; jk1846.
DR KEGG; cjk:jk1846; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_1_11; -.
DR OMA; FMTWEGY; -.
DR Proteomes; UP000000545; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1164
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000224047"
FT REGION 975..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1143..1164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1164 AA; 129104 MW; 943B2E18A2C9E6DD CRC64;
MAVSRQTSSV AGIPGAPQRH SFAKIDAPIE VPGLLDLQRE SFAWLVGTPE WRARAQAEAG
EDVRIMSGLE EILEELSPIE DYSENMSLTL SEPRFDDVKS TIDEAKDKDI NYAAPLYVTA
EFTNSMSGEI KSQTVFIGDF PMMTDKGTFI INGTERVVVS QLVRSPGVYF DASIDASTER
PLHSVKVIPS RGAWLEFDVD KRDTVGVRID RKRRQPVTVL LKALGLTTQE ITDRFGFSEL
MMSTLEKDGV DNTDEALLEI YRKQRPGESP TRDSAQALLE NSFFKAKRYD LAKVGRYKVN
RKLGLGGDTD GVMTLTEEDI LTTIEYLVRL HAGEKSMTSP DGTEIPIDTD DIDHFGNRRL
RTVGELIQNQ VRVGLSRMER VVRERMTTQD AESITPTSLI NVRPVSAAIR EFFGTSQLSQ
FLDQNNSLSG LTHKRRLSAL GPGGLSRERA GLEVRDVHPS HYGRMCPIET PEGPNIGLIG
SLSSYARVNP FGFIETPYRK VVDGQITDEV YYFTADEEDR HVIAQANTPF DENHRFTEER
IEVRLRGGDV EVVPYTEVDY MDVSPRQMVS VATAMIPFLE HDDANRALMG ANMQRQAVPL
LRSEAPFVGT GMELRAAYDA GDMIIAPKAG VVEYVSADYI TVMDDEGVRD TFMLRKFERT
NQGTCYNQTP LVDEGDRVEA GQVLADGPGT DNGEMALGKN LLVAFMPWEG HNYEDAIILN
QRMVEEDVLT SIHIEEYEID ARDTKLGPEE ITRDIPNVGE DVLADLDERG IVRIGADVRD
GDILVGKVTP KGETELTPEE RLLRAIFGEK AREVRDTSMK VPHGETGKVI GVRVFSREDD
DDLAAGVNEM VRVYVAQKRK IQDGDKLAGR HGNKGVVGKI LPQEDMPFLP DGTPIDIILN
THGVPRRMNI GQVLEVHLGW LAKAGWKVDP DSQDPKIQKM LETLPEELYE IPADSLTATP
VFDGASNAEL SGLLRSSLPN RDGERQVDDF GKSNLIDGRS GEPFPYPVAV GYMYMLKLHH
LVDEKIHARS TGPYSMITQQ PLGGKAQFGG QRFGEMEVWA MQAYGAAYTL QELLTIKSDD
VVGRVKVYEA IVKGENIPDP GIPESFKVLL KELQSLCLNV EVLAADGTPM ELSSDDDDEL
ENANAALGIN LSRDERPDAD MDVS
