AB39G_ARATH
ID AB39G_ARATH Reviewed; 1454 AA.
AC Q7PC84; Q9C623; Q9FZI3;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=ABC transporter G family member 39;
DE Short=ABC transporter ABCG.39;
DE Short=AtABCG39;
DE AltName: Full=Pleiotropic drug resistance protein 11;
GN Name=ABCG39; Synonyms=PDR11, PDR13; OrderedLocusNames=At1g66950;
GN ORFNames=F1O19.3, T4O24.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP IDENTIFICATION.
RX PubMed=12430018; DOI=10.1007/s00425-002-0889-z;
RA van den Brule S., Smart C.C.;
RT "The plant PDR family of ABC transporters.";
RL Planta 216:95-106(2002).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16506311; DOI=10.1016/j.febslet.2005.12.043;
RA Crouzet J., Trombik T., Fraysse A.S., Boutry M.;
RT "Organization and function of the plant pleiotropic drug resistance ABC
RT transporter family.";
RL FEBS Lett. 580:1123-1130(2006).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- FUNCTION: May be a general defense protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF98206.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAG50592.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007152; AAF98206.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC083891; AAG50592.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34577.1; -; Genomic_DNA.
DR EMBL; BK001010; DAA00879.1; -; Genomic_DNA.
DR PIR; D96693; D96693.
DR RefSeq; NP_176867.2; NM_105366.4.
DR AlphaFoldDB; Q7PC84; -.
DR SMR; Q7PC84; -.
DR BioGRID; 28234; 1.
DR STRING; 3702.AT1G66950.1; -.
DR TCDB; 3.A.1.205.22; the atp-binding cassette (abc) superfamily.
DR PaxDb; Q7PC84; -.
DR PRIDE; Q7PC84; -.
DR ProteomicsDB; 244619; -.
DR EnsemblPlants; AT1G66950.1; AT1G66950.1; AT1G66950.
DR GeneID; 843013; -.
DR Gramene; AT1G66950.1; AT1G66950.1; AT1G66950.
DR KEGG; ath:AT1G66950; -.
DR Araport; AT1G66950; -.
DR TAIR; locus:2019693; AT1G66950.
DR eggNOG; KOG0065; Eukaryota.
DR HOGENOM; CLU_000604_35_6_1; -.
DR InParanoid; Q7PC84; -.
DR OMA; QILWGEK; -.
DR OrthoDB; 324553at2759; -.
DR PhylomeDB; Q7PC84; -.
DR PRO; PR:Q7PC84; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q7PC84; baseline and differential.
DR Genevisible; Q7PC84; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000302; P:response to reactive oxygen species; IEP:TAIR.
DR GO; GO:0042908; P:xenobiotic transport; IMP:TAIR.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1454
FT /note="ABC transporter G family member 39"
FT /id="PRO_0000234638"
FT TRANSMEM 544..564
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 584..604
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 623..643
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 663..683
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 689..709
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 716..736
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 775..795
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1199..1219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1231..1251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1285..1303
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TRANSMEM 1312..1332
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1342..1362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1367..1387
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1423..1443
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 175..448
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 526..739
FT /note="ABC transmembrane type-2 1"
FT /evidence="ECO:0000305"
FT DOMAIN 853..1106
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1178..1392
FT /note="ABC transmembrane type-2 2"
FT /evidence="ECO:0000305"
FT REGION 812..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 208..215
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 898..905
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1454 AA; 165193 MW; 23780923FFB35DF5 CRC64;
MAAMLGRDED PVGALSGRVS LASTSHRSLV GASKSFRDVF MPQTDEVFGR SERREEDDME
LRWAAIERLP TFDRLRKGML PQTSANGKIE LEDIDLTRLE PKDKKHLMEM ILSFVEEDNE
KFLRDLRERT DRVGIEVPKI EVRYENISVE GDVRSASRAL PTLFNVTLNT LESILGFFHL
LPSKRKKIQI LKDISGIVKP SRMTLLLGPP SSGKTTLLQA LAGKLDDTLQ MSGRITYCGH
EFREFVPQKT CAYISQHDLH FGEMTVREIL DFSGRCLGVG SRYQLMSELS RREKEEGIKP
DPKIDAFMKS IAISGQETSL VTDYVLKILG LDICADILAG DVMRRGISGG QKKRLTTGEM
LVGPARALFM DEISTGLDSS TTFQICKFMR QLVHISDVTM IISLLQPAPE TFELFDDIIL
LSEGQIVYQG PRDNVLEFFE YFGFQCPERK GVADFLQEVT SKKDQEQYWN KREQPYNYVS
VSDFSSGFST FHTGQKLTSE FRVPYDKAKT HSAALVTQKY GISNWELFKA CFDREWLLMK
RNSFVYVFKT VQITIMSLIT MTVYLRTEMH VGTVRDGQKF YGAMFFSLIN VMFNGLAELA
FTVMRLPVFY KQRDFLFYPP WAFALPAWLL KIPLSLIESG IWIGLTYYTI GFAPSAARFF
RQLLAYFCVN QMALSLFRFL GAIGRTEVIS NSIGTFTLLI VFTLGGFIIA KDDIRPWMTW
AYYMSPMMYG QTAIVMNEFL DERWSSPNYD TRINAKTVGE VLLKSRGFFT EPYWFWICIV
ALLGFSLLFN LFYILALMYL NPLGNSKATV VEEGKDKQKG ENRGTEGSVV ELNSSSNKGP
KRGMVLPFQP LSLAFNNVNY YVDMPSEMKA QGVEGDRLQL LRDVGGAFRP GILTALVGVS
GAGKTTLMDV LAGRKTGGYI EGSISISGYP KNQTTFARVS GYCEQNDIHS PHVTVYESLI
YSAWLRLSTD IDIKTRELFV EEVMELVELK PLRNSIVGLP GVDGLSTEQR KRLTIAVELV
ANPSIIFMDE PTSGLDARAA AIVMRTVRNT VDTGRTVVCT IHQPSIDIFE SFDELLLMKR
GGQVIYAGSL GHHSQKLVEY FEAVEGVPKI NDGYNPATWM LDVTTPSMES QMSLDFAQIF
SNSSLYRRNQ ELIKDLSTPP PGSKDVYFKT KYAQSFSTQT KACFWKQYWS YWRHPQYNAI
RFLMTVVIGV LFGLIFWQIG TKTENEQDLN NFFGAMYAAV LFLGALNAAT VQPAIAIERT
VFYREKAAGM YSAIPYAISQ VAVEIMYNTI QTGVYTLILY SMIGCNWTMA KFLWFYYYML
TSFIYFTLYG MMLMALTPNY QIAGICMSFF LSLWNLFSGF LIPRPQIPIW WRWYYWATPV
AWTLYGLITS QVGDKDSMVH ISGIGDIDLK TLLKEGFGFE HDFLPVVAVV HIAWILLFLF
VFAYGIKFLN FQRR
