RPOB_CORU7
ID RPOB_CORU7 Reviewed; 1170 AA.
AC B1VES1;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=cu0300;
OS Corynebacterium urealyticum (strain ATCC 43042 / DSM 7109).
OC Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC Corynebacterium.
OX NCBI_TaxID=504474;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43042 / DSM 7109;
RX PubMed=18367281; DOI=10.1016/j.jbiotec.2008.02.009;
RA Tauch A., Trost E., Tilker A., Ludewig U., Schneiker S., Goesmann A.,
RA Arnold W., Bekel T., Brinkrolf K., Brune I., Goetker S., Kalinowski J.,
RA Kamp P.-B., Lobo F.P., Viehoever P., Weisshaar B., Soriano F., Droege M.,
RA Puehler A.;
RT "The lifestyle of Corynebacterium urealyticum derived from its complete
RT genome sequence established by pyrosequencing.";
RL J. Biotechnol. 136:11-21(2008).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; AM942444; CAQ04260.1; -; Genomic_DNA.
DR RefSeq; WP_012359561.1; NC_010545.1.
DR AlphaFoldDB; B1VES1; -.
DR SMR; B1VES1; -.
DR STRING; 504474.cu0300; -.
DR PRIDE; B1VES1; -.
DR EnsemblBacteria; CAQ04260; CAQ04260; cu0300.
DR GeneID; 60605103; -.
DR KEGG; cur:cu0300; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_1_11; -.
DR OMA; FMTWEGY; -.
DR OrthoDB; 9601at2; -.
DR Proteomes; UP000001727; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1170
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_1000141681"
SQ SEQUENCE 1170 AA; 129574 MW; 9FA795063E15194C CRC64;
MLEGPILAVS RQTSSVAGIP GASTRYSFAK IDAPIEVPGL LDLQRESFAW LVGAPEWRAR
MQAEAGEGVR VTSGLEDILE ELSPIEDYSE NMSLTLSEPR FDDMKTSIDE AKEKDINYAA
PLYVTAEFTN AQSGEIKSQT VFIGDFPMMT DKGTFIINGT ERVVVSQLVR SPGVYFDESI
DTSTERPLHG VKVIPSRGAW LEFDVDKRDT VGVRIDRKRR QPVTVLLKAL GLTTQEITDR
FGFSEIMMST LEKDGVENTD EALLEIYRKQ RPGESPTRDS AQALLENSFF RPKRYDLAKV
GRYKVNRKLG LGGDTDGTMT LTEEDILTTI EYLVRLHAGE RTMTSPEGVE IPIEVDDIDH
FGNRRLRTVG ELIQNQVRVG LSRMERVVRE RMTTQDAESI TPTSLINVRP VSAAIREFFG
TSQLSQFMDQ NNSLSGLTHK RRLNALGPGG LSRERAGLEV RDVHPSHYGR MCPIETPEGP
NIGLIGSLSS YARVNPFGFI ETPYRRVVDG QITDEVEYFT ADEEDRHVIA QANTPFDADM
KFTEDQIEVR LRGGDVEVVP ASQVDYMDVS PRQMVSVATA MIPFLEHDDA NRALMGANMQ
RQAVPLLRAE APYVGTGIEQ RAAYDAGDLI IAPKAGVVEY VSADYITIMD DEGIRDTFML
RKFERTNQGT SYNQKPLVNQ GDRVEAGQVI ADGPGTDNGE MALGKNLLVA FMPWEGHNYE
DAIILSQRMV EEDVLTSIHI EEYEIDARDT KLGPEEITRD IPNVGEDVLA DLDERGIVRI
GADVRDGDIL VGKVTPKGET ELTPEERLLR AIFGEKAREV RDTSMKVPHG ETGKVIGVRV
FSREDDDDLA AGVNEMVRVY VAQKRKIQDG DKLAGRHGNK GVVGKILPQE DMPFLPDGTP
VDIILNTHGV PRRMNIGQVL EVHLGWLAKA GWQVDTNSDD PKIKAMLETL PEDLYDVPAD
SLTSTPVFDG ASNAELSGLL RSSRPDRDGI RLVDDFGKAQ LIDGRTGEPY EHPISVGYMY
MLKLHHLVDE KIHARSTGPY SMITQQPLGG KAQFGGQRFG EMEVWAMQAY GAAYTLQELL
TIKSDDVVGR VKVYEAIVKG ENIPDPGIPE SFKVLLKELQ SLCLNVEVLA ADGTPMELSS
DDDDELESAN AALGINLQRD ERPDADIDVG
