ID   RPOB_DEHM1              Reviewed;        1272 AA.
AC   Q3Z8V4;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN   Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=DET0603;
OS   Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195)
OS   (Dehalococcoides ethenogenes (strain 195)).
OC   Bacteria; Chloroflexi; Dehalococcoidia; Dehalococcoidales;
OC   Dehalococcoidaceae; Dehalococcoides.
OX   NCBI_TaxID=243164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-2266 / KCTC 15142 / 195;
RX   PubMed=15637277; DOI=10.1126/science.1102226;
RA   Seshadri R., Adrian L., Fouts D.E., Eisen J.A., Phillippy A.M., Methe B.A.,
RA   Ward N.L., Nelson W.C., DeBoy R.T., Khouri H.M., Kolonay J.F., Dodson R.J.,
RA   Daugherty S.C., Brinkac L.M., Sullivan S.A., Madupu R., Nelson K.E.,
RA   Kang K.H., Impraim M., Tran K., Robinson J.M., Forberger H.A., Fraser C.M.,
RA   Zinder S.H., Heidelberg J.F.;
RT   "Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides
RT   ethenogenes.";
RL   Science 307:105-108(2005).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC   -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC       and 1 omega subunit. When a sigma factor is associated with the core
CC       the holoenzyme is formed, which can initiate transcription.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR   EMBL; CP000027; AAW40097.1; -; Genomic_DNA.
DR   RefSeq; WP_010936378.1; NC_002936.3.
DR   AlphaFoldDB; Q3Z8V4; -.
DR   SMR; Q3Z8V4; -.
DR   STRING; 243164.DET0603; -.
DR   PRIDE; Q3Z8V4; -.
DR   EnsemblBacteria; AAW40097; AAW40097; DET0603.
DR   KEGG; det:DET0603; -.
DR   PATRIC; fig|243164.10.peg.581; -.
DR   eggNOG; COG0085; Bacteria.
DR   HOGENOM; CLU_000524_4_3_0; -.
DR   OMA; FMTWEGY; -.
DR   OrthoDB; 9601at2; -.
DR   Proteomes; UP000008289; Chromosome.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00653; RNA_pol_B_RPB2; 1.
DR   Gene3D; 2.30.150.10; -; 1.
DR   Gene3D; 2.40.270.10; -; 2.
DR   Gene3D; 3.90.1110.10; -; 1.
DR   HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR   InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR   InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR   InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR   InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR   InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR   InterPro; IPR010243; RNA_pol_bsu_bac.
DR   InterPro; IPR007121; RNA_pol_bsu_CS.
DR   InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR   InterPro; IPR007642; RNA_pol_Rpb2_2.
DR   InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR   InterPro; IPR007645; RNA_pol_Rpb2_3.
DR   InterPro; IPR007641; RNA_pol_Rpb2_7.
DR   PANTHER; PTHR20856; PTHR20856; 1.
DR   Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR   Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR   Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR   Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR   Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR   Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR   PROSITE; PS01166; RNA_POL_BETA; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transcription; Transferase.
FT   CHAIN           1..1272
FT                   /note="DNA-directed RNA polymerase subunit beta"
FT                   /id="PRO_0000224049"
FT   REGION          1250..1272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1272 AA;  141366 MW;  AFBB698CF021FAC8 CRC64;
     MVSMLPKADA ATGITRKSYA QLPEVVNVPN LIEMQLQSFV WFQEEGLREL IEEISPIKDF
     VGNRLELEFI GYEFREPRLS EYECTQRDQT YSVPLYVKAR LIVKTTGEIK EPFDLFFGDI
     PLMTALGTFI TSGTERVVVS QLLRSPGVYF TISDDPATGR PLCHTNLIPS RGAWLEFETS
     NRDVISVKID GRRKIPVSTL LRAIGYSDDL DILNLFEVID NDPERHYIQS SIDRDPLIKD
     EISALIDIYS RLRPGDPPNA DNARKLINEM FFDPQHYDLG KVGRYKVNRR LELPDREVGD
     NRALTREDIV AIIKRIIMVN NGQDTPDDID HLGNRRIRTV GELVQNQFRI GLVRLERVAR
     ERMSIVNLEV VTPSALVNIR PVVSAVKEFF GGSQLSQFMD QTNPLAEITN KRRLSAMGPG
     GLSRERAGFD VRDVHYSHYG RICPIETPEG PNIGLIGSLA TYSRINRYGF VETPYRKVYS
     KLKNNDKKLV GLKLAAAVSD KDKVLASAGS VVSEENFKLI SKLPECDIQV MPFVSAEVKY
     MPADEEDRYI IAQANTRLDE NGYFLDERIE ARLAERYVIE PPEKIDYMDV SPKQIFSVAA
     SLIPFLEHDD ANRALMGANM QRQAVPLLRA EAPMVATGME REAARYSGQV IFAKRAGVAA
     SVTSEKIIIR TAEGQDDEYL LKKFVRTNQG TCINQHAVIN KGQKIEAGQV LADSSATENG
     ELALGQNCVV AFMSWQGFNY EDAIILSERL VREDAFTSIH ITKHELEAHD TKLGGEEITR
     DIPNVGEESL RELDEDGIIR IGAEVGPDDI LVGKITPKGE TELSAEEKLL RAIFGEKARE
     VKDTSLRMPH GEWGKVINVR VFSRENGDDL PARVNKWVQV WVAQKRKVSV GDKLAGRHGN
     KGVISIIAPV EDMPYLPDGT PVDVVLNPIG VPSRMNLGQI LETHLGWAGH LLGFRVATPV
     FDGADDTAIE DALARSWLSA KAGATDMSPE NKRPSTDTAK AVEWIKQQGF DGKKVFDERH
     PGLAKEVSLK LWLKDMGVDA SSLSGAELEK KAYEVSSQSR LPSPIVGKSV LRDGRTGETF
     DQPVTVGNMY ILKLIHLVED KVHARATGPY SLISQQPLGG KAQFGGQRFG EMEVWAMYAY
     GTAHNLQEML TIKSDDIAGR AKAYESIVKG EDVIQPGVPE SFKVLVKELQ SLGLAVEVIN
     EEVKIAPSEK VAALTEANLP GSEDVSAEIL PETLYAGAED IEDSMMSVID TDDQDLAMSS
     NDEEVSENDE RS