RPOB_DEIGD
ID RPOB_DEIGD Reviewed; 1152 AA.
AC Q1J0P6;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2006, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=Dgeo_0636;
OS Deinococcus geothermalis (strain DSM 11300 / AG-3a).
OC Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=319795;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11300 / AG-3a;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Daly M.J.,
RA Fredrickson J.K., Makarova K.S., Gaidamakova E.K., Zhai M., Richardson P.;
RT "Complete sequence of chromosome 1 of Deinococcus geothermalis DSM 11300.";
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; CP000359; ABF44938.1; -; Genomic_DNA.
DR RefSeq; WP_011529779.1; NC_008025.1.
DR AlphaFoldDB; Q1J0P6; -.
DR SMR; Q1J0P6; -.
DR STRING; 319795.Dgeo_0636; -.
DR EnsemblBacteria; ABF44938; ABF44938; Dgeo_0636.
DR KEGG; dge:Dgeo_0636; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_1_0; -.
DR OMA; FMTWEGY; -.
DR OrthoDB; 9601at2; -.
DR Proteomes; UP000002431; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1152
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000300306"
SQ SEQUENCE 1152 AA; 127384 MW; 96B3CDD047D81E7E CRC64;
MSLTDQKPRI ERFGEITEVI PLPNLTEVQV NSFKAFLQAD KAPDERDDTG LQSAFREVFP
IDETEKGRST GLVLDFLEYR LGEPPYTPEE CREKDLTYQA PLYAKLQLIH KDSGLIKEDQ
VFLGDLPLMT DDGSFVINGA DRVVISQIHR SPGVYFTSSY KGIKKMYTAA IIPMPKRGPW
IELEFNGGVL EMKVNKRKFP VSLLLRVLGY DDAQLKALFT EFDPAAELPE DKSAGMNPDE
ALLRLFTVLR PGDPPKRDKA IQYLYGLLAD PKRYDLGEPG RFKMNTKLGT RRQDRTLLTF
EDGRFGDAGL VDTIRYLMAL QQGLETVTMG ADEDGVAIEV PVTEDDIDHL GNRRVRTVGE
LLADQLRVGM GRMARGVRER MLLGNPDAAT PTKLVNNRPI VAAMREFFGR SQLSQFKDQT
NPLSDLRHKR RISALGPGGL TRERAGFDVR DVHRTHYGRI CPIETPEGAN IGLISSLSSY
AKVNDLGFIE APYRRVVDGR VTDDVVYMTA DIEDRYVIAQ ANSPLNPDGT FAEERVLARK
KGDPMLYAPT EVDFMDVSPK QIVSINTSLI PFLEHDDANR ALMGSNMQSQ AVPLVRADSP
AVGTGVEERV VTDSGTSVIS DVTGRVTYVD ARAIQVTLTE DAPQIGLVKG NVRTFELVRF
TRSNQGTNLD QHPIVSVGDE VVPGQVIADG PASDQGRLAL GQNITIAIMP FDGFNFEDAI
CISEGLVRKD FYTSVHIEKD EIEARDTKLG PEKITRDIPG LSEAALRDLD EDGIVRVGAE
VKPGDILVGK TSFKGESEPT PEERLLRSIF GEKAREVKDT SLRVQSGQGG IVVKTVRFRR
GDEGVDLKPG VREMVRVYVA QKRQLQVGDK VANRHGNKGV VSKILPPEDM PYLEDGTPVD
LVFNPLGVPS RMNLGQILET HLGEVARLTG QKFVTPVFDS ATEEAIKEML EVAAAERLQR
RKDEGFELDK REQEVLDRAG KLGVISPPNG DYAAAQMQLA RTGKSVLYDG RTGEPISGPV
VVGTMYVMKL YHMVEDKLHA RSTGPYSLIT QQPLGGKAQF GGQRFGEMEV WALEAYGAAH
TLQEMLTIKS DDIDGRDAAY QSIVKGEEVS GSTIPESFKV LVKELHSLGL DVEVLDNNDK
PVDIFEGMMP KR
