RPOB_DESVM
ID RPOB_DESVM Reviewed; 1372 AA.
AC B8DLM7;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=DvMF_1455;
OS Desulfovibrio vulgaris (strain DSM 19637 / Miyazaki F).
OC Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC Desulfovibrionaceae; Desulfovibrio.
OX NCBI_TaxID=883;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19637 / Miyazaki F;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Hazen T.C.,
RA Richardson P.;
RT "Complete sequence of Desulfovibrio vulgaris str. 'Miyazaki F'.";
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; CP001197; ACL08403.1; -; Genomic_DNA.
DR RefSeq; WP_012612584.1; NC_011769.1.
DR AlphaFoldDB; B8DLM7; -.
DR SMR; B8DLM7; -.
DR STRING; 883.DvMF_1455; -.
DR EnsemblBacteria; ACL08403; ACL08403; DvMF_1455.
DR KEGG; dvm:DvMF_1455; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_0_7; -.
DR OMA; FMTWEGY; -.
DR OrthoDB; 9601at2; -.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription;
KW Transferase.
FT CHAIN 1..1372
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_1000141686"
SQ SEQUENCE 1372 AA; 152810 MW; E9632A04D0164E27 CRC64;
MGQLTKKFGK IPVSLGIPHL LNLQVDSYVK FLQEGLAERK TDEGLEGVFR SVFPIEDFNR
TASLEYVSYD IGEPKFDQAE CISKGLTYEA PIRIKVRLVV YDVDDDSGNR TIRDIKEQDI
YFGTLPLMTE KGTFIINGTE RVIVNQLQRS PGIIFEHDSG KTHSSRKVLY SCRVIPMRGS
WLDFDFDHKD ILYVRIDRRR KMPATILFKA MGMTKTDILD YFYKKEFYRI SADGRVFWEV
QKDMFRKDSA FADIAGPDGT VFVKAGKPIT KRAWRQICEA GLETIEVAAD TLDGLFLADD
VVNPATGEVL AEAADEVTPG VQERLREAGI DRLPILHTKG IDTSSSLRDT LVLDKTADKE
AAQVEIYRRL RPSSPPTPEI AESFFDNLFR SADYYDLSPV GRYKLNQRLG LDQSLELRVL
TDEDILTAIR VLLHLKDSHG PADDIDHLGN RRVRPVGELV ENQYRIGLVR MERAIKERMS
LQEVSTLMPH DLINPKPVAA VLKEFFGTSQ LSQFMDQTNA LSEVTHKRRL SALGPGGLTR
ERAGFEVRDV HTSHYGRICP IETPEGPNIG LIVSLTTYAK VNDYGFIETP YHVIRDTKMT
GEVVYLDASR EHGEVIAQAN APFDAEGKLA DEYVTTRVKG DVLMSPREEV TLMDVSPSQM
VSISAALIPF LEHDDANRAL MGSNMQRQAV PLLQCEKPLV GTGMEGPVAQ DSGACIIAEG
PGIVRYADAD RIIVSYENGL YPERGGVRAY DLQKFHKSNQ NSCFGQKPTC HPGQIVAKGD
ILADGPGIED GELALGKNLV VAFMPWCGYN FEDSILISER TVKEDTFTSV HIEEFEVVAR
DTKLGPEEIT RDIPNVGEDM LRNLDGSGII RIGANVKPDD ILVGKITPKG ETQLTPEEKL
LRAIFGDKAR DVKNTSLKVP PGIEGTVIEV KVFNRRSGEK DERARLIEEY ELGRLDRKEQ
DHIRGLGDAT RVKLMAVVEG KQIATTLAGK KKGEVIAEAG ASVTAEMLAD VPLKKLSGLF
KNREVNEAVD ALLESYDQQV QFISNIYESK RGKVTEGDDL PPGVIKMVKV YIAVKRKLSV
GDKMAGRHGN KGVVSCILPA EDMPFFADGR PVDIVLNPLG VPSRMNIGQI METHLGWAAK
EMGRQLAEML ERNDPLKALR NEVKRAFDSP AIDSLVDSMD DEDFRASVAK LGRGIVTKTP
VFDGAAEEEI WSWLVRANID EDGKTVLYDG RTGERFHNRV TTGVMYMLKL HHLVDEKIHA
RSTGPYSLVT QQPLGGKAQF GGQRLGEMEV WALEAYGAAY LLQEFLTVKS DDVTGRVKMY
EKIVKGDNFL EAGLPESFNV LVKELMSLGL DVTLHQEEGK KRPKRVGFMN AL
