RPOB_DICNV
ID RPOB_DICNV Reviewed; 1361 AA.
AC A5EX70;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=DNO_1282;
OS Dichelobacter nodosus (strain VCS1703A).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Cardiobacteriales;
OC Cardiobacteriaceae; Dichelobacter.
OX NCBI_TaxID=246195;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VCS1703A;
RX PubMed=17468768; DOI=10.1038/nbt1302;
RA Myers G.S.A., Parker D., Al-Hasani K., Kennan R.M., Seemann T., Ren Q.,
RA Badger J.H., Selengut J.D., Deboy R.T., Tettelin H., Boyce J.D.,
RA McCarl V.P., Han X., Nelson W.C., Madupu R., Mohamoud Y., Holley T.,
RA Fedorova N., Khouri H., Bottomley S.P., Whittington R.J., Adler B.,
RA Songer J.G., Rood J.I., Paulsen I.T.;
RT "Genome sequence and identification of candidate vaccine antigens from the
RT animal pathogen Dichelobacter nodosus.";
RL Nat. Biotechnol. 25:569-575(2007).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; CP000513; ABQ14048.1; -; Genomic_DNA.
DR RefSeq; WP_012031577.1; NC_009446.1.
DR AlphaFoldDB; A5EX70; -.
DR SMR; A5EX70; -.
DR STRING; 246195.DNO_1282; -.
DR PRIDE; A5EX70; -.
DR EnsemblBacteria; ABQ14048; ABQ14048; DNO_1282.
DR KEGG; dno:DNO_1282; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_1_6; -.
DR OMA; FMTWEGY; -.
DR OrthoDB; 9601at2; -.
DR Proteomes; UP000000248; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1361
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000300309"
SQ SEQUENCE 1361 AA; 152468 MW; 6EF9E4D6199F1C54 CRC64;
MTTYSFTEKK RIRKNFSKRP TVLETPYLLS MQIDSYNDFL QQHVPMQSRA KKGLQEAFES
IFPIKSHNEM VELQFVGYEF GKPEFDVREC QLRGVTYAAP LRVRMRLAIY DKNSTKKKLK
QVVESESVYM GDIPLMTDDG TFVINGTERV IVSQLHRSPG VFFGDDDGQG HSSGKKLYNA
RIIPYRGSWL DLEFDVKDLI YCRIDRRRKL LITILLRALG LSNQEMLDIF FSKQTFKLNK
TGKIELVFEP EQFAGELAQF DIIADGEVIV PMGRKISSRF VRQLIEKKVK KQTVPVDFVV
GKFLATDLVD KETGELILAA NSELTEELLT RFVELGVKEF QTLLINENGH GGYLADTLRL
DETTTELEAR AEIYRMMRPG EPPTKEAADS LFEGLFFDEA RYDLSRVGRM KFNRSLGREE
SEGSGILSKE DIIGVVKKLI AIKDGFGSTD DIDHLGNRRI RSVGEMAENA FRIGLVRLER
TVKERLAQAE SEGLTPKDLI NVKPVGAAVK EFFSSSQLSQ FMDQNNPLSE VTHKRRISAL
GPGGLTRERA GFEVRDVHPT HYGRLCPIET PEGPNIGLIN SLAVYARTNE YGFLETPYRK
VIDGKVTDEI EYLSAIDESK YVIAQANAHL DEHGAFMDGL ISTRFENEFT LMPSSRVQYM
DVSPRQIVSV AASLIPFLEH DDANRALMGS NMQRQAVPTL RADKPLVGTG MERVVAMDSG
VLVKAARGGV IDSVDSSRIV VKVNDDEVQA GGLGVDIYNL TKYTRSNQNT CINQKPLVSP
GDIVARGDVL ADGPSTDMGE LALGQNVLVA FMPWNGYNYE DSILISERVS QEDRFTTIHI
EELTCIARDT KLGPEEISSD IPNVKESALA KLDTTGIVYV GAEVKFGDIL VGKVTPKGER
SQSPEEKLLR AIFGEKASDV KDSSLRVPTG MDGTVVDVRV YTRDGIEKDE RAKAIEKMEI
DSIAKDIKDQ LRIFSADIHD RAARLLLGQA IKKAPKRKSG DTVDQALLDE TTPEQWFDFR
MQDEAINEKL DAMKQLLEDK HKELQDYYEE KKAKFSQGDD LAPGVLKMVK VYLAVKRRLQ
PGDKMAGRHG NKGVVSLVVP VEDMPYMEDG TPVDIVLNPL GVPSRMNIGQ VLELHLGWAA
AGLGKRLAQM MDEGAPIKEL RRYLDAVYNH NPACKKEDLD ALSDEDFWQL CRNLRQGIPM
ATPVFDGAEE VEDLQKMLEL AELPATGQTH LYDGRTGERF DREVSVGYMY MLKLHHLVDD
KMHARSTGPY SLVTQQPLGG RAQFGGQRFG EMEVWALQAY GASYTLQEML TVKSDDVDGR
TKMYKNIVDG NLKIEPGLPE SFNVLTKEIR ALGIDIGLTQ D
