RPOB_FERNB
ID RPOB_FERNB Reviewed; 1182 AA.
AC A7HNY2;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=Fnod_1782;
OS Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1).
OC Bacteria; Thermotogae; Thermotogales; Fervidobacteriaceae;
OC Fervidobacterium.
OX NCBI_TaxID=381764;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35602 / DSM 5306 / Rt17-B1;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C.,
RA Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.;
RT "Complete sequence of Fervidobacterium nodosum Rt17-B1.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; CP000771; ABS61615.1; -; Genomic_DNA.
DR RefSeq; WP_011994906.1; NC_009718.1.
DR AlphaFoldDB; A7HNY2; -.
DR SMR; A7HNY2; -.
DR STRING; 381764.Fnod_1782; -.
DR PRIDE; A7HNY2; -.
DR EnsemblBacteria; ABS61615; ABS61615; Fnod_1782.
DR KEGG; fno:Fnod_1782; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_0_0; -.
DR OMA; FMTWEGY; -.
DR OrthoDB; 9601at2; -.
DR Proteomes; UP000002415; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1182
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000329176"
SQ SEQUENCE 1182 AA; 133664 MW; 2D0EB01839DBFFBA CRC64;
MKTYQIGKRT RYSFGKVDEI IQVPDLVEIQ RKSFEELLNH GILRILKKFS PITSAKVEGR
REKGFNLEFV NFRVGAPLHS VEECKQRLLT YVAPFYATVR VTDVSTGEMR EEEVSLGNYP
IMTENQTFVI NGVERVVVSQ LVRSPGVYFV EEPTKNIGAK PIYLAHFLPV RGVWLEIMLN
LNDETLYARI DRRKRLNLFL VLKTLGFQND IDILSLFPAY LDVEDDYSLK QSEGIIILEK
IVSKSGEVIA EKGSVLTSTL VEILREHGIE KIKVVNNYMF KTYMKLKEKL KMPLEENISE
LRAFMEIYKE LRPGEVFRYN AAKSYWNNLY FNEERFELSE VGRYKMNKKL TNAYRKYLIE
IEGRNPKSVE RIEYEEKSNA LTPIDIILVI RMLLETEKHP ETLDTKDHLS NKRVKTVGEL
IGSEFERAFS KSIHQIQEKL ATYTSLDKIS IPSLINLRNV IASLNSFFAT NPLSQFMDQV
NPIAELTHKR RLTAVGPGGL KRERARFEVR DVHHSHYGRM CPIETPEGGN IGLITSLSVY
ATIDEYGFLV TPYRRITNGK LANEVVYLAA DEEENYKIAS VTIAFDKEGN IIQERVPVRY
LEKIVYVHKN EVDLVDISPK QIVSVTTSLI PFLEHDDANR ALMGSNMQRQ AVPVIKPEAP
FVGTGMEYAA AIYSGHVVLA KNDGVVKKVD GRKIIIHRID ENGQLMYDKK GNPIIDEYTL
LKYVRSNQDT SITQKPIVNV GDFVKKGSPI ADGPATDNGE LALGKNVLVA FLPWEGYNFE
DAILVSEELL EEDTFTSVHI EVYETTARET RVGPEEITSE IPNVSKENIR NLDENGIIRI
GAYVGKQKYF TSQDILVGKV TPKGESDASP EEKIMRSVFG EKGKDVKDSS LRVPHGVEGR
VIGVHVFHKE EVGDLGPGVN TLVRVYLATR KPLEVGDKLA GRHGNKGVVS MILPKEDMPF
LPDGTPVQVV LSPLGVPSRM NIGQVLETSL GWLAKLTNRY FATPVFDGAK EDDILPELYK
VRETLNLHHG DDPNNPSGKV TLRDGRTGKE FDFPVLVGYM YIMKLIHIAR DKIHARATGP
YSLIHQQPLG GKAQFGGQRF GEMEVWALEA YGASYTLNEM LTVKSDDIKG RTEVYKAIMK
SKNLPEPGLP ESFKVLVREL KGLALDVRVY DEHGNEIDIE KL
