ID   RPOB_FRACC              Reviewed;        1141 AA.
AC   Q2JFI5;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN   Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321};
GN   OrderedLocusNames=Francci3_0573;
OS   Frankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3).
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=106370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45818 / CECT 9043 / CcI3;
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A.,
RA   Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P.,
RA   Goltsman E., Huang Y., Kopp O.R., Labarre L., Lapidus A., Lavire C.,
RA   Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J.,
RA   Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F.,
RA   Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C.,
RA   Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC   -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC       and 1 omega subunit. When a sigma factor is associated with the core
CC       the holoenzyme is formed, which can initiate transcription.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000249; ABD09957.1; -; Genomic_DNA.
DR   RefSeq; WP_011435032.1; NZ_JENI01000032.1.
DR   AlphaFoldDB; Q2JFI5; -.
DR   SMR; Q2JFI5; -.
DR   STRING; 106370.Francci3_0573; -.
DR   PRIDE; Q2JFI5; -.
DR   EnsemblBacteria; ABD09957; ABD09957; Francci3_0573.
DR   KEGG; fra:Francci3_0573; -.
DR   eggNOG; COG0085; Bacteria.
DR   HOGENOM; CLU_000524_4_3_11; -.
DR   OMA; FMTWEGY; -.
DR   OrthoDB; 9601at2; -.
DR   PhylomeDB; Q2JFI5; -.
DR   Proteomes; UP000001937; Chromosome.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00653; RNA_pol_B_RPB2; 1.
DR   Gene3D; 2.30.150.10; -; 1.
DR   Gene3D; 2.40.270.10; -; 1.
DR   Gene3D; 2.40.50.150; -; 1.
DR   Gene3D; 3.90.1110.10; -; 1.
DR   HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR   InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR   InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR   InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR   InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR   InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR   InterPro; IPR010243; RNA_pol_bsu_bac.
DR   InterPro; IPR007121; RNA_pol_bsu_CS.
DR   InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR   InterPro; IPR007642; RNA_pol_Rpb2_2.
DR   InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR   InterPro; IPR007645; RNA_pol_Rpb2_3.
DR   InterPro; IPR007641; RNA_pol_Rpb2_7.
DR   InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR   PANTHER; PTHR20856; PTHR20856; 1.
DR   Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR   Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR   Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR   Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR   Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR   Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR   TIGRFAMs; TIGR02013; rpoB; 1.
DR   PROSITE; PS01166; RNA_POL_BETA; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transcription; Transferase.
FT   CHAIN           1..1141
FT                   /note="DNA-directed RNA polymerase subunit beta"
FT                   /id="PRO_0000237300"
SQ   SEQUENCE   1141 AA;  126456 MW;  7503A5F4597D7263 CRC64;
     MAASRSSSRI SFAKIIEPLE VPDLLALQTQ SFDWLIGSDA WAERVQEAID SGRDDVPITS
     GLEEVFKEIS PIEDFSGSMS LSFRDHRFEP PKYSVEECKD KDMTFSAPLF VTAEFTNNNT
     GEIKSQTVFM GDFPLMTPKG TFVINGTERV VVSQLVRSPG VYFERSLDKA SDKDLYSCKV
     IPSRGAWLEF EIDKRDTVGV RIDRKRRQSV TVLLKALGWD EARILERFGD FPSMRITLEK
     DHTAGQDDAL LDIYRKLRPG EPPTRESAQT LLENLFFNPK RYDLAKVGRY KVNKKLSLGV
     AHDVGVLTEN DIVRTIEYVV KLHAGADPAE YEVDDIDHFG NRRIRTVGEL IQNQVRLGLA
     RMERVVRERM TTQDVEAITP QTLINIRPVV ASIKEFFGTS QLSQFMDQTN PLAGLTHKRR
     LNALGPGGLS RERAGFEVRD VHPSHYGRMC PIETPEGPNI GLIGSLSTFA RVNPFGFIET
     PYRKVENGRV TGQIDWLTAD EEDRHVKAQA NTPLRPDGSF AEDRVLVRRK GGEVEFIPPD
     EVDYMDVSPR QMVSVATAMI PFLEHDDANR ALMGSNMQRQ SVPLLRSEAP LVGTGMEARA
     AKDAGDVVVC AQAGVVEDLS ADYITVMHDD GTRRTYRLAK FRRSNQGTCI NQKPIVNEGD
     RVGAGQVIAD GPCTDNGEMA LGKNLLVAFM PWEGHNYEDA IILSQRLVQD DVLSSIHIEE
     HEVDARDTKL GPEEITRDIP NVAEEVLADL DERGIIRIGA EVSPGDVLVG KVTPKGETEL
     TPEERLLRAI FGEKAREVRD TSLKVPHGES GKVIGVRVFS REDGDELPPG VNELVRVYVA
     QKRKITDGDK LAGRHGNKGV IAKILPAEDM PFLEDGTPVD VVLNPHGVPR RMNIGQILET
     HLGWVAKTGW QVDSGTEDWK ERLRGIGADA ASAGTNVATP VFDGAREEEI TGLLDSTLPN
     RDGIQLIGSS GKAKLFDGRT GEPYPYPVAV GYIYILKLLH LVDDKIHARS TGPYSMITQQ
     PLGGKAQFGG QRFGEMEVWA LEAYGAAYAL QELLTIKSDD VVGRVKVYEA IVKGENIPEP
     GIPESFKVLI KEMQSLCLNV EVLSSDGVQI EMRDTDEDVF RAAEELGIDL SRREPSSVEE
     V