RPOB_FUSNN
ID RPOB_FUSNN Reviewed; 1184 AA.
AC Q8RHI6;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=FN2036;
OS Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 /
OS BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355).
OC Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; Fusobacterium.
OX NCBI_TaxID=190304;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC
RC 2640 / LMG 13131 / VPI 4355;
RX PubMed=11889109; DOI=10.1128/jb.184.7.2005-2018.2002;
RA Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A.,
RA Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O.,
RA Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N., D'Souza M.,
RA Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N.C.,
RA Overbeek R.;
RT "Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum
RT strain ATCC 25586.";
RL J. Bacteriol. 184:2005-2018(2002).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; AE009951; AAL94121.1; -; Genomic_DNA.
DR RefSeq; NP_602822.1; NC_003454.1.
DR AlphaFoldDB; Q8RHI6; -.
DR SMR; Q8RHI6; -.
DR STRING; 190304.FN2036; -.
DR EnsemblBacteria; AAL94121; AAL94121; FN2036.
DR KEGG; fnu:FN2036; -.
DR PATRIC; fig|190304.8.peg.499; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_3_0; -.
DR InParanoid; Q8RHI6; -.
DR OMA; FMTWEGY; -.
DR BioCyc; FNUC190304:G1FZS-523-MON; -.
DR Proteomes; UP000002521; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1184
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000047903"
SQ SEQUENCE 1184 AA; 133126 MW; A764AF579F2AAFF9 CRC64;
MQKLIERLDF GKIKARGEMP HFLEFQLNSY EDFLQTNMSP NKREEKGFEL AFKEIFPIES
SNGDVRLEYI GYELHEAEAP LNDELECKKR GKTYSNSLKV RLRLINKKMG NEIQESLVYF
GEVPKMTDRA TFIINGAERV VVSQLHRSPG VSFSKEVNTQ TGKDLFSGKI IPYKGTWLEF
ETDKNDFLSV KIDRKKKVLA TVFLKAVDFF KDNNEIRDYF LEVKELKLKA LYKKYSKEPE
ELLNVLKQEL DGSIVKEDIL DEETGEFIAE AEAFINEEVI NKLIENKVDK ISYWYVGPES
KLVANTLMND TTLTEDEAVV EVFKKLRPGD QVTVDSARSL IRQMFFNPQR YDLEPVGRYK
MNKRLKLDVP EEQISLTKED VLGTIKYVIE LNNGEQNVHT DDIDNLSNRR IRGVGELLLM
QIKTGLAKMN KMVREKMTTQ DIETVTPQSL LNTRPLNALI QDFFGSGQLS QFMDQSNPLA
ELTHKRRISA LGPGGLSRER AGFEVRDVHD SHYGRICPIE TPEGPNIGLI GSLATYAKIN
KYGFIETPYV KVENGVALVD DVRYLAADEE DGLFIAQADT KLDKNNKLQG LVVCRYGHEI
VEIEPERVNY MDVSPKQVVS VSAGLIPFLE HDDANRALMG SNMQRQAVPL LKSEAPFIGT
GLERKVAVDS GAVVTTKVSG KVTYVDGKKI IIEDKDKKEH IYRLLNYERS NQSMCLHQTP
LVDLGDKVKA GDIIADGPAT KLGDLSLGRN ILMGFMPWEG YNYEDAILIS DRLRKDDVFT
SIHIEEYEID ARTTKLGDEE ITREIPNVSE SALRNLDENG VIMIGSEVGP GDILVGKTAP
KGETEPPAEE KLLRAIFGEK ARDVRDTSLT MPHGSKGVVV DILELSRENG DELKAGVNKS
IRVLVAEKRK ITVGDKMSGR HGNKGVVSRV LPAEDMPFLE DGTHLDVVLN PLGVPSRMNI
GQVLEVHLGM AMRTLNGGTC IATPVFDGAT EEQVKDYLEK QGYPRTGKVT LYDGRTGEKF
DNKVTVGIMY MLKLHHLVED KMHARAIGPY SLVTQQPLGG KAQFGGQRLG EMEVWALEAY
GASNILQEML TVKSDDITGR TKTYEAIIKG EAMPESDLPE SFKVLLKEFQ ALALDIELCD
EEDNVINVDE EIGIEETPTE YSPQYEIEMT GLHEIDEDAE DFEE
