RPOB_GEOMG
ID RPOB_GEOMG Reviewed; 1370 AA.
AC Q39Y13;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=Gmet_0619;
OS Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15).
OC Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC Geobacteraceae; Geobacter.
OX NCBI_TaxID=269799;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 53774 / DSM 7210 / GS-15;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J.,
RA Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.;
RT "Complete sequence of Geobacter metallireducens GS-15.";
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; CP000148; ABB30861.1; -; Genomic_DNA.
DR RefSeq; WP_004514635.1; NC_007517.1.
DR AlphaFoldDB; Q39Y13; -.
DR SMR; Q39Y13; -.
DR STRING; 269799.Gmet_0619; -.
DR EnsemblBacteria; ABB30861; ABB30861; Gmet_0619.
DR KEGG; gme:Gmet_0619; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_0_7; -.
DR OMA; FMTWEGY; -.
DR OrthoDB; 9601at2; -.
DR Proteomes; UP000007073; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1370
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000237301"
SQ SEQUENCE 1370 AA; 152879 MW; 1CB760929BA37A23 CRC64;
MAYSIANNQL LRQNFAKIKK IIDIPNLIDI QKNSYKRFLQ IDTPPEARKN SGLEAVFKSV
FPIKDFSDTA SLEYVSYSLG TPKYDVEECH QRGMTFAAPM KVKVRLVVWD VNKDTGVRSI
RDIKEQEVYF GEIPLMTENG TFIINGTERV IVSQLHRSPG VFYDHDKGKT HSSGKVLYSA
RVIPYRGSWL DFEFDHKDIL YVRIDRRRKM PATVLLKALG NSAEELLNFY YRSEEIGLDG
ERMWKKADAE LLTTQKTSSD IVDSKTGEVI IKANRKFTKA AIRKMTEHGI TEIPIKAEEV
CGKYASTDIV DPATGEVLVE CNEEISQAKL DEIKARGISE FKVLFIDNLH VTSSLRDTLL
VDKINTTDDA LIEIYRRLRP GDPPTLKSAQ ALFDNLFFNA ERYDLSAVGR LKLNYKLGLG
VPLDCQVLTK EDILEVVRYL IDLKNGRGTI DDIDHLGNRR VRAVGELLEN QYRIGLVRME
RAIKERMSLQ EVENLMPHDL INSKPVSAVV KEFFGSSQLS QFMDQTNPLS EVTHKRRLSA
LGPGGLTRER AGFEVRDVHP THYGRVCPIE TPEGPNIGLI ASLSTYARIN EHGFVETPYR
IVSEGKVTAE VKFFSALEEE GHAIAQANAE MDADGRFVND YVSARKSGEF LLVHRDELEL
MDVAPMQLVS VAASLIPFLE NDDANRALMG SNMQRQAVPL LKADSPLVGT GMERVVAKDS
GVSVVARHTG VVESVDASRI VVKIDEDEYD ETGTGVDIYN LIKFARSNQN TCINQRPVVK
VGDHVKRGDV IADGPSTDMG ELALGQNVVV AFMPWGGYNF EDSILISEKL TKDDRYTSIH
IEEFECVARD TKLGKEEITS DIPNLGEETL KDLDESGIIR IGAEVKPGDI MVGKITPKGE
TQLSPEEKLL RAIFGEKAGD VRDTSLRVPP GVEGTVIGAK VFSRKGNDKD SRTEMIERME
EEKLRKDEQD EIRIIRDSAV GKLKRLLVGK TAAVKVEDKN GKTVIAKDAA ITEEALTAIP
LDRWDEISVS GGEGVEEKVA AILATLQQQI DIIKYVFDDK VQKLKRGDDL PPGVIKMVKV
YIAIKRKLQV GDKMAGRHGN KGVVSRILPE EDMPYMEDGR PVEIVLNPLG VPSRMNVGQI
LETHLGWAAK GIGWKIEEML EKHSPSATIK EYLQKVYGSK EMNAFLDSLN EEELINVAKR
LQRGVPMASP VFEGASEEQI RSMLDKAGFD ETAQVRLFDG KTGEPFKHKV TVGVMYVLKL
HHLVDDKIHA RSIGPYSLVT QQPLGGKAQF GGQRLGEMEV WAMEAYGAAY ALQEFLTVKS
DDVAGRTRMY EAIVKGKHTL EPGLPESFNV LIKELQSLCL DVELLEGDED
