RPOB_LACLM
ID RPOB_LACLM Reviewed; 1196 AA.
AC A2RML9;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=llmg_1982;
OS Lactococcus lactis subsp. cremoris (strain MG1363).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus; Lactococcus cremoris subsp. cremoris.
OX NCBI_TaxID=416870;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MG1363;
RX PubMed=17307855; DOI=10.1128/jb.01768-06;
RA Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA van Sinderen D., Kok J.;
RT "The complete genome sequence of the lactic acid bacterial paradigm
RT Lactococcus lactis subsp. cremoris MG1363.";
RL J. Bacteriol. 189:3256-3270(2007).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM406671; CAL98553.1; -; Genomic_DNA.
DR RefSeq; WP_011835718.1; NZ_WJVF01000004.1.
DR AlphaFoldDB; A2RML9; -.
DR SMR; A2RML9; -.
DR STRING; 416870.llmg_1982; -.
DR EnsemblBacteria; CAL98553; CAL98553; llmg_1982.
DR GeneID; 61110128; -.
DR KEGG; llm:llmg_1982; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_1_9; -.
DR OMA; FMTWEGY; -.
DR PhylomeDB; A2RML9; -.
DR BioCyc; LLAC416870:LLMG_RS09935-MON; -.
DR Proteomes; UP000000364; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription;
KW Transferase.
FT CHAIN 1..1196
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000300335"
SQ SEQUENCE 1196 AA; 133169 MW; 53DF3C2480A3CEE3 CRC64;
MAGHDVKYGK HRTRRSFSRI KEVIGLPNLI EVQTLSYKNF LDEGLANVFK EMFPIDNFAG
TMELEFVGYE MKTPKYTVEE ARAHDANYSA PIYVTFRLVN KETGELKTQE VFFGDFPLMT
EMGTFINNGS ERLIVSQLVR SPGSYFHLKT DKNGLESFGH TTIPNRGAWF ELDTDAKGIG
YVRIDRTRKL TFTTMLRALG FGSDDEILEL LGETQLLTDT IAKDVHKNPA DTRVEEALKD
IYDRLRPGEP KTADSSRGLL VARFFDPKRY DFAPVGRYKF NKKLALKNRL LGLTLAEPIV
DPETGEILVN TDTLVTRDVL DLIEPLLDNG LGNFVVEPSD DAVIPEPITL QSIKVYSPKD
SERVVTLLSN GNPDSECRVL TPADVISNIS YWLGLAEGIG KVDDIDHLGN RRIRSVGELL
QNQVRIGLSR MERVIRERMS SSENENITPQ GLINIRPVTA SIKEFFGSSQ LSQFMDQHNP
LSELSHKRRF SALGPGGISR DRASYEVRDV HYTHYGRMCP IETPEGPNIG LINNLSSYAK
VNEYGFIMSP YRRVDRVNGI VTDEVEYLTA DEEDNYTVAQ ANSPLTDDSR FANETVMARH
TGNNIEVEAS TADYMDVSPK QVIAVAAACI PFLENDDSNR ALMGANMQRQ AVPLIDPHAP
WIGTGMEHQT ARDSGAALLA KHAGVVEYVD GNEIRVRRTS GELDIYNITK YRRSNSGTSY
NQRPLARLGE KVEKNDIIAD GPSMENGEMA LGQNPLVAYM TWEGYNFEDA VIMSERLIKD
DVYTSIAIEE YESETRDTKL GPEEITREIP NVGDEALKNL DESGIIRIGA EVKDGDLLVG
KVTPKGETDP TPEERLLRAI FGEKAREVRD TSLRVPHGGG GIVHDVRVFT RENGDELPSG
VNKLVRVFIA QKRKIHVGDK MAGRHGNKGV VSNIVPVEDM PYLPDGTPID IMLNPLGVPS
RMNIGQVMEL HLGMAARTLG IHIATPVFDG ASDEDIWDTV KEAGMAADAK TVLYDGRTGE
PFDNRISVGV MYMIKLHHMV DDKLHARSVG PYSLVTQQPL GGKAQFGGQR FGEMEVWALE
AYGAANVLQE ILTYKSDDVI GRTRAYEAIV KGERIPKPGL PESFRVLVKE LQSLGLDMKV
LDADRNVLDL RELDEDEVMT RPDNTEITPE MLEAQEAIVA QAEAEEEALI NADIEK
