ID   RPOB_LEGPH              Reviewed;        1368 AA.
AC   Q5ZYQ0;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN   Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=lpg0322;
OS   Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC
OS   33152 / DSM 7513).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=272624;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513;
RX   PubMed=15448271; DOI=10.1126/science.1099776;
RA   Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G.,
RA   Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V.,
RA   Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A.,
RA   Chou I.-C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A.,
RA   Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A.,
RA   Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A.,
RA   Russo J.J.;
RT   "The genomic sequence of the accidental pathogen Legionella pneumophila.";
RL   Science 305:1966-1968(2004).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC   -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC       and 1 omega subunit. When a sigma factor is associated with the core
CC       the holoenzyme is formed, which can initiate transcription.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR   EMBL; AE017354; AAU26419.1; -; Genomic_DNA.
DR   RefSeq; WP_010946073.1; NC_002942.5.
DR   RefSeq; YP_094366.1; NC_002942.5.
DR   AlphaFoldDB; Q5ZYQ0; -.
DR   SMR; Q5ZYQ0; -.
DR   STRING; 272624.lpg0322; -.
DR   PaxDb; Q5ZYQ0; -.
DR   PRIDE; Q5ZYQ0; -.
DR   EnsemblBacteria; AAU26419; AAU26419; lpg0322.
DR   GeneID; 66489521; -.
DR   KEGG; lpn:lpg0322; -.
DR   PATRIC; fig|272624.6.peg.329; -.
DR   eggNOG; COG0085; Bacteria.
DR   HOGENOM; CLU_000524_4_3_6; -.
DR   OMA; FMTWEGY; -.
DR   Proteomes; UP000000609; Chromosome.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00653; RNA_pol_B_RPB2; 1.
DR   Gene3D; 2.30.150.10; -; 1.
DR   Gene3D; 2.40.270.10; -; 2.
DR   Gene3D; 2.40.50.150; -; 1.
DR   Gene3D; 3.90.1110.10; -; 2.
DR   HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR   InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR   InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR   InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR   InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR   InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR   InterPro; IPR010243; RNA_pol_bsu_bac.
DR   InterPro; IPR007121; RNA_pol_bsu_CS.
DR   InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR   InterPro; IPR007642; RNA_pol_Rpb2_2.
DR   InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR   InterPro; IPR007645; RNA_pol_Rpb2_3.
DR   InterPro; IPR007641; RNA_pol_Rpb2_7.
DR   InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR   PANTHER; PTHR20856; PTHR20856; 1.
DR   Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR   Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR   Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR   Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR   Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR   Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR   TIGRFAMs; TIGR02013; rpoB; 1.
DR   PROSITE; PS01166; RNA_POL_BETA; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transcription; Transferase.
FT   CHAIN           1..1368
FT                   /note="DNA-directed RNA polymerase subunit beta"
FT                   /id="PRO_0000224069"
SQ   SEQUENCE   1368 AA;  152719 MW;  A9C5702CDAA64E6C CRC64;
     MAVAEAKPQY SHAEKKRFRK SFGKQTDIMP IPNLLEIQLK SYRDFLQTDT KLSEQLNTGL
     HAAFSSVFPI ESFSGNARLE YVGYKLGEPA FDVRECKLRG LTYSAPLRVK IRLVVLDKDA
     SDDPKPIKDI REQDVFMGEI PLMTDVGTFV VNGTERVVVS QLHRSPGVIF EHDKGKTHSS
     GKLLYSARII PYRGSWLDFE FDPKDCVYVR IDRRRKLPVT ILLRALGYEA EDILSEFFET
     THCHLKNGEY HIDLIPQRLR GEIASFDIHV PETGELIVEQ GRRITARHIK QMEKSQMQDL
     VVPRDYLIGK TLAKNIIDTS TGEFLAQAND EITEELLDAM ANHGILQIDM IYTNDLDHGS
     YISDTLKIDP TGSQLEALVE IYRMMRPGEP PTKEAAEALF KNLFFVEERY DLSAVGRMKF
     NRRVGIKSDE GPGTLTKEDI LSVIKTLIDI RNGIGMVDDI DHLGNRRVRS VGEMTENQFR
     VGLVRVERAV KERLSLVESE NLMPQDLINA KPVSAAIKEF FGSSQLSQFM DQVNPLSGVT
     HKRRVSALGP GGLTRERAGF EVRDVHTTHY GRVCPIETPE GPNIGLINSL SVYARTNEYG
     FIETPCRKVV NGRVTDEVEY LSAIEEVDQY IAQSNVELDA QGNILADLVP CRHQNEFSLT
     TPDKINYMDV SPKQIVSVAA SLIPFLEHDD ANRALMGSNM QRQAVPTLRS EKPLVGTGME
     RIVASDSGVS VVAKRGGVID LVDASRIVVR VNDDETTAGE TGVDIYNLTK YFRSNQDTCI
     NQRPIVSTGD RIQRGDVLAD GPCTDMGELA LGQNLLVAFM PWNGYNFEDS ILISERIVHD
     DRFTTIHIEE LTCIARDTKL GTEEITADIP NVGESALSNL DESGVVYIGA EVKAGDILVG
     KVTPKGETQL TPEEKLLRAI FGEKASDVKD SSLRVPSGMN GTVIDVQVFT RDGLEKDARA
     KSIEEEHLAR VRKDLIDERR IREEDIYHRV SHLLLDKVAT GGPGSLKPGS KITQDYLDKV
     EREKWFDIRI EDDAISQQLE QLSKQLELLT KEMEKRFNDS RKKIIQGDDL APGVLKIVKV
     YLAVKRRIQP GDKMAGRHGN KGVISIVVPV EDMPHMEDGT AVDIVLNPLG VPSRMNIGQV
     LETHLGLAAK GLGRKIAQML DEKQTPEAIK AYLEKIYNHD GVQRVNLKCL NDDELMTLAD
     NLRAGVPMAT PVFDGATEQE IKSMLQLADL PADGKTVLID GRTGNKFDNP VTVGYMYMLK
     LNHLVDDKMH ARSTGSYSLV TQQPLGGKAQ FGGQRFGEME VWALEAYGAA YTLQEMLTVK
     SDDVGGRTKI YKNIVDGDHR MDPGMPESFN VLLKEIRALG IDIELEHD