ID   AB3A_ARATH              Reviewed;         932 AA.
AC   Q1PEH6; F4JCP2; Q9STT9;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 3.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=ABC transporter A family member 3;
DE            Short=ABC transporter ABCA.3;
DE            Short=AtABCA3;
DE   AltName: Full=ABC2 homolog 2;
GN   Name=ABCA3; Synonyms=ATH2; OrderedLocusNames=At3g47740; ORFNames=T23J7.70;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-928.
RC   STRAIN=cv. Columbia;
RA   Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA   Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA   Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT   "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL   J. Biol. Chem. 276:30231-30244(2001).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA   Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA   Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA   Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT   "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL   Trends Plant Sci. 13:151-159(2008).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC       CPR flippase (TC 3.A.1.211) subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABE65998.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC       Sequence=CAB41857.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL049746; CAB41857.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE78324.1; -; Genomic_DNA.
DR   EMBL; DQ446742; ABE65998.1; ALT_SEQ; mRNA.
DR   PIR; T07713; T07713.
DR   RefSeq; NP_190358.3; NM_114642.4.
DR   AlphaFoldDB; Q1PEH6; -.
DR   SMR; Q1PEH6; -.
DR   STRING; 3702.AT3G47740.1; -.
DR   PaxDb; Q1PEH6; -.
DR   PRIDE; Q1PEH6; -.
DR   EnsemblPlants; AT3G47740.1; AT3G47740.1; AT3G47740.
DR   GeneID; 823928; -.
DR   Gramene; AT3G47740.1; AT3G47740.1; AT3G47740.
DR   KEGG; ath:AT3G47740; -.
DR   Araport; AT3G47740; -.
DR   TAIR; locus:2100377; AT3G47740.
DR   eggNOG; KOG0059; Eukaryota.
DR   HOGENOM; CLU_000604_19_5_1; -.
DR   InParanoid; Q1PEH6; -.
DR   OMA; FIEMMIG; -.
DR   OrthoDB; 130188at2759; -.
DR   BioCyc; ARA:AT3G47740-MON; -.
DR   PRO; PR:Q1PEH6; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q1PEH6; baseline and differential.
DR   Genevisible; Q1PEH6; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR   GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR026082; ABCA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR19229; PTHR19229; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..932
FT                   /note="ABC transporter A family member 3"
FT                   /id="PRO_0000240324"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        453..473
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        483..500
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        526..546
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          610..847
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         648..655
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   932 AA;  105337 MW;  1AD74C499D6BA9D1 CRC64;
     MADSGPASFW TRANAILRKN LTYQKRNIWS NVRLIMIPFY LCIVLVFIQA LFDSQVNNSL
     DNQCGCQCID KLGDGKCQMT CGLEYSTRDQ GFFCAIPKPQ PWPPLILIPR PEYRALDANF
     TNDSCRRKNS CPVTILFTGN NHSLGAVLSR NLLRRPFAMN SSDLLFSLAN NVLATTFKGS
     ATNYLDAGIV SDGSIYNIQP RCPPNSNFSI SIGQSPLNFT KDMRCVQGLN LWRNNSIEVN
     LELFEGYHKG NSDGMINEIV AAYDLFDTNM TNFNVNIWFN ATYKDEARNQ PYKVVRVPRL
     VNWVSNAYLQ YLQGPRTKML FEFVKEMPKP ETKLRLDIAS LIGPIFFTWV ILLLLPVILN
     SLVYEKQQRL RIIMKMHGLG DGPYWIISYA YFLALSTFYI IFLMIFGSVI GLKFFLLNDF
     SLQFSFYFVY INLQISIAFL LSSAFSKVET ASVAAYLYVF GSGLLGMFLF QFLLEGLSFP
     RRWIFVMELY PGFSLYRGLY EFSQNAYQGN LNGKDGMKWK YFSDNAIDEV FYIIIVEWFV
     ALIATYYIDK MSSSGKDLLF FLKNQNPFKI SHSLQKQVSA ISVEMEKLDV IHESEKVAQL
     MLESSTSHAI VCDKLRKVYP GRDGNPPKKA VRVLSLAVPS GECFGMLGPN GAGKTSFINM
     MTGLVKPTSG AAFVQGLDIC KDMDRVYTSM GVCPQHDLLW ETLTGREHLL FYGRLKNLKG
     VDLNQAVEES LRSVNLFHGG VADKPAGKYS GGMKRRLSVA ISLIGNPKVV YMDEPSTGLD
     PASRKNLWTV IKNAKRHTAI ILTTHSMEEA EFLCDRLGIF VDGRLQCIGN PKELKGRYGG
     SYVLTMTTSS EHEKDVEMLV QEVSPNVKKI YHIAGTQKFE IPKDEVRISE VFQVVEKAKS
     NFKVFAWGLA DTTLEDVFIK VARTAQAFNV FS