RPOB_MYCMO
ID RPOB_MYCMO Reviewed; 1188 AA.
AC Q6KI09;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=MMOB2810;
OS Mycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711) (Mesomycoplasma
OS mobile).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mesomycoplasma.
OX NCBI_TaxID=267748;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43663 / 163K / NCTC 11711;
RX PubMed=15289470; DOI=10.1101/gr.2674004;
RA Jaffe J.D., Stange-Thomann N., Smith C., DeCaprio D., Fisher S., Butler J.,
RA Calvo S., Elkins T., FitzGerald M.G., Hafez N., Kodira C.D., Major J.,
RA Wang S., Wilkinson J., Nicol R., Nusbaum C., Birren B., Berg H.C.,
RA Church G.M.;
RT "The complete genome and proteome of Mycoplasma mobile.";
RL Genome Res. 14:1447-1461(2004).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; AE017308; AAT27767.1; -; Genomic_DNA.
DR RefSeq; WP_011264801.1; NC_006908.1.
DR AlphaFoldDB; Q6KI09; -.
DR SMR; Q6KI09; -.
DR STRING; 267748.MMOB2810; -.
DR PRIDE; Q6KI09; -.
DR EnsemblBacteria; AAT27767; AAT27767; MMOB2810.
DR KEGG; mmo:MMOB2810; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_1_14; -.
DR OMA; FMTWEGY; -.
DR OrthoDB; 9601at2; -.
DR Proteomes; UP000009072; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 3.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1188
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000224078"
SQ SEQUENCE 1188 AA; 132457 MW; C77B9C310A2D9ACF CRC64;
MIKHKLRKFG PVTERRDYSQ TNRTWETFDF LETQKKSFKW FIDEGINQAL NDIYPIHSNN
GKVIIEYVNN SAKLEYKTDN EYKILAEARQ KGTTYSGILK AKLTKTIVET GEIETAEVLY
GDVPIMTSGG TFLINGSEKI IVSQLIRSPG AYFGLKVRNK QADDLFNKLE IIPKLGSWIE
ISHRVTGNTT DTVKVKIDKH KAVSLVTFLR AMGMKKETIQ NLFGSHSTLE GENPILKETL
NKEKFKTEDD ALEYLYSVIW RGNNRITAES KSNLLSNILF NPRRYNLSKT GRYMLNRKLS
LVDRIIGTYL AEDLFSAKGT KNAKLVFAKG TLITREIAEK IQDSFKNNIF NLIPIPDVSS
DIYAAQLETN PKLAERIRVI SLNIYPNKTW MEQNTNPIIV IANDPNSTEL HLLASDLVAI
VSYYFNLVDR VGQDDDPDSL INKRIVGVGE LLENQFKIGL SKLEKNAKER MSAKEIEKIT
PKNITNSKPV YNQFKTFFNS SKLSQFMDQV NPLAEISNKR RVTSLGPGGL NRETAQFEVR
DVHSTHYGRI CPIETPEGPN IGLILNFATY AKVNDFGFIQ SPYFKVNDGI IDYEKPIFLT
AAEEIDKKFA QSTVSVDKDG KITTQNITVR QNHDYLIVSP SEVDYIDISS KQMTSIAAAA
IPFLENNDAN RALMGSNMQR QAIPLLEAEA PLVATGIEAD IAKFSVSNLI VKEEGEVSYV
DGTKIKVKSK NDKSKTYYLK NFEHSNQGTL LSQKPIVKLG DKVEIGDLLT DASSFKDGEM
ALGKNVMIAF STWNGYNYED AIVISERLVK DDVFTSVHIE DQTIQFRTSK AGSDKLTREI
PNVSNFSKRN LDEEGIVKVG SEVVAGDILV GRVSPKGEEN PSPEEKLLAA IFQKKPSTDK
DTSLKVKHGH AGTVLDVQVL SRASGDVLED SVEKIVKVSI AQKRKIKVGD KMAGRHGNKG
VISIVAPVED MPHLEDGTVI DIILNPQGVP SRMNIGQVLE LHLGMAAKTL STKFVSPGFD
GLKFGTIQEI LKEAKLPENG KFTLIDPMTG EKFDNKVSVG IMYMLKLSHM VDDKMHARSI
GPYSLITQQP LGGKSQNGGQ RFGEMETWAL EAHGASNILQ EILTYKSDNI EGRKGLYNSL
ATGNKIPAPG TPESFNVLSY ELRGLSIKLE SQAHFKNAQI VKEVMDNE
