ID   RPOB_MYCSJ              Reviewed;        1172 AA.
AC   A3PV78;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN   Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=Mjls_0997;
OS   Mycobacterium sp. (strain JLS).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; unclassified Mycobacterium.
OX   NCBI_TaxID=164757;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JLS;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Anderson A.J.,
RA   Sims R.C., Richardson P.;
RT   "Complete sequence of Mycobacterium sp. JLS.";
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC   -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC       and 1 omega subunit. When a sigma factor is associated with the core
CC       the holoenzyme is formed, which can initiate transcription.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR   EMBL; CP000580; ABN96805.1; -; Genomic_DNA.
DR   AlphaFoldDB; A3PV78; -.
DR   SMR; A3PV78; -.
DR   STRING; 164757.Mjls_0997; -.
DR   KEGG; mjl:Mjls_0997; -.
DR   HOGENOM; CLU_000524_4_3_11; -.
DR   OMA; FMTWEGY; -.
DR   BioCyc; MSP164757:G1G8C-1009-MON; -.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00653; RNA_pol_B_RPB2; 1.
DR   Gene3D; 2.30.150.10; -; 1.
DR   Gene3D; 2.40.270.10; -; 1.
DR   Gene3D; 2.40.50.150; -; 1.
DR   Gene3D; 3.90.1110.10; -; 1.
DR   HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR   InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR   InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR   InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR   InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR   InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR   InterPro; IPR010243; RNA_pol_bsu_bac.
DR   InterPro; IPR007121; RNA_pol_bsu_CS.
DR   InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR   InterPro; IPR007642; RNA_pol_Rpb2_2.
DR   InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR   InterPro; IPR007645; RNA_pol_Rpb2_3.
DR   InterPro; IPR007641; RNA_pol_Rpb2_7.
DR   InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR   PANTHER; PTHR20856; PTHR20856; 1.
DR   Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR   Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR   Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR   Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR   Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR   Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR   TIGRFAMs; TIGR02013; rpoB; 1.
DR   PROSITE; PS01166; RNA_POL_BETA; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription;
KW   Transferase.
FT   CHAIN           1..1172
FT                   /note="DNA-directed RNA polymerase subunit beta"
FT                   /id="PRO_0000300350"
SQ   SEQUENCE   1172 AA;  129079 MW;  F84A0673C6D63D81 CRC64;
     MLEGCILAVS SQSKSAKAIT NNSVPGAPNR ISFAKLREPL EVPGLLDVQT ESFDWLIGAD
     SWRQRATARG DVNPTGGLEE VLTELSPIED FSGSMSLSFS DPRFDEVKAP VDECKDKDMT
     YAAPLFVTAE FINNNTGEIK SQTVFMGDFP MMTEKGTFII NGTERVVVSQ LVRSPGVYFD
     ESIDKSTEKT LHSVKVIPGR GAWLEFDVDK RDTVGVRIDR KRRQPVTVLL KALGWTNEQI
     TERFGFSEIM MSTLEKDNTA GTDEALLDIY RKLRPGEPPT KESAQTLLEN LFFKEKRYDL
     ARVGRYKVNK KLGLNTDKPI TSSTLTEEDV VATIEYLVRL HEGQATMTVP GGVEVPVEVD
     DIDHFGNRRL RTVGELIQNQ IRVGLSRMER VVRERMTTQD VEAITPQTLI NIRPVVAAIK
     EFFGTSQLSQ FMDQNNPLSG LTHKRRLSAL GPGGLSRERA GLEVRDVHSS HYGRMCPIET
     PEGPNIGLIG SLSVYARVNP FGFIETPYRK VENGVVTDQI DYLTADEEDR HVVAQANSPL
     DDEGHFTEDR VLVRRKGGEV EFVSATEVDY MDVSPRQMVS VATAMIPFLE HDDANRALMG
     ANMQRQAVPL VRSEAPLVGT GMELRAAIDA GDVVVSEKAG VVEEVSADYI TVMADDGTRH
     TYRMRKFARS NHGTCANQRP IVDAGQRVEA GQVVADGPCT QNGEMALGKN LLVAIMPWEG
     HNYEDAIILS NRLVEEDVLT SIHIEEHEID ARDTKLGAEE ITRDIPNVSD EVLADLDERG
     IVRIGAEVRD GDILVGKVTP KGETELTPEE RLLRAIFGEK AREVRDTSLK VPHGESGKVI
     GIRVFSREDD DELPAGVNEL VRVYVAQKRK ISDGDKLAGR HGNKGVIGKI LPVEDMPFLP
     DGTPVDIILN THGVPRRMNI GQILETHLGW VAKAGWNINV AGADGVPDWA EKLPEELYSA
     PSDSIVATPV FDGARENELS GLLASTLPNR DGDVMVNEDG KAELFDGRSG EPFPYPVTVG
     YMYILKLHHL VDDKIHARST GPYSMITQQP LGGKAQFGGQ RFGEMECWAM QAYGAAYTLQ
     ELLTIKSDDT VGRVKVYEAI VKGENIPEPG IPESFKVLLK ELQSLCLNVE VLSSDGAAIE
     MRDGDDEDLE RAAANLGINL SRNESASVED LA