RPOB_MYCVP
ID RPOB_MYCVP Reviewed; 1167 AA.
AC A1T4J2;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=Mvan_1257;
OS Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 /
OS KCTC 9966 / NRRL B-24157 / PYR-1) (Mycobacterium vanbaalenii).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=350058;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 /
RC PYR-1;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Anderson I.J., Miller C., Richardson P.;
RT "Complete sequence of Mycobacterium vanbaalenii PYR-1.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABM12092.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CP000511; ABM12092.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_036370198.1; NC_008726.1.
DR AlphaFoldDB; A1T4J2; -.
DR SMR; A1T4J2; -.
DR STRING; 350058.Mvan_1257; -.
DR EnsemblBacteria; ABM12092; ABM12092; Mvan_1257.
DR KEGG; mva:Mvan_1257; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_1_11; -.
DR OrthoDB; 9601at2; -.
DR Proteomes; UP000009159; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1167
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000300355"
SQ SEQUENCE 1167 AA; 128489 MW; C8D5685BE1619A43 CRC64;
MLEGCILAGS RQIESTTNNS VPGAPNRISF AKLREPLEVP GLLDVQTESF EWLIGAEDWF
QRAADRGDVD PKGGLQEVLE ELSPIEDFSG SMSLSFSDPR FDEVKAPVDE CKDKDMTYAA
PLFVTAEFIN NNTGEIKSQT VFMGDFPMMT EKGTFIINGT ERVVVSQLVR SPGVYFDESI
DKSTEKTLHS VKVIPGRGAW LEFDVDKRDT VGVRIDRKRR QPVTVLLKAL GWTNEQIVER
FGFSEIMMST LEKDNTAGTD EALLDIYRKL RPGEPPTKES AQTLLENLFF KEKRYDLARV
GRYKVNKKLG LNVGQPITSS TLTEEDVVAT IEYLVRLHQG DQTMTAPGGS EVPVEVDDID
HFGNRRLRTV GELIQNQIRV GLSRMERVVR ERMTTQDVEA ITPQTLINIR PVVAAIKEFF
GTSQLSQFMD QNNPLSGLTH KRRLSALGPG GLSRERAGLE VRDVHSSHYG RMCPIETPEG
PNIGLIGSLS VYARVNPFGF IETPYRKVTD GVVTDQIDYL TADEEDRHVV AQANSPLDGD
GHFEEERVLV RRKGGEVEFV SAAEVDYMDV SPRQMVSVAT AMIPFLEHDD ANRALMGANM
QRQAVPLVRS EAPLVGTGME LRAAIDAGDV VVTEKAGVVE EVSADYITVM ADDGTRHTYR
MRKFARSNHG TCANQRPIVD AGQRVESGQV LADGPCTENG EMALGKNLLV AIMPWEGHNY
EDAIILSNRL VEEDVLTSIH IEEHEIDARD TKLGAEEITR DIPNVSDEVL ADLDERGIIR
IGAEVRDGDI LVGKVTPKGE TELTPEERLL RAIFGEKARE VRDTSLKVPH GESGKVIGIR
VFSREDDDEL PAGVNELVRV YVAQKRKISD GDKLAGRHGN KGVIGKILPV EDMPFLPDGT
PVDIILNTHG VPRRMNIGQI LETHLGWVAK AGWNIDVAAG TPEWAAKLPE QMLSAPADSI
VATPVFDGAQ EGELQGLLGS TLPNRDGETM VNADGKATLF DGRSGEPFPY PVTVGYMYIL
KLHHLVDDKI HARSTGPYSM ITQQPLGGKA QFGGQRFGEM ECWAMQAYGA AYTLQELLTI
KSDDTVGRVK VYEAIVKGEN IPEPGIPESF KVLLKELQSL CLNVEVLSSD GAAIEMRDGD
DEDLERAAAN LGINLSRNES ASVEDLA
