RPOB_MYXXD
ID RPOB_MYXXD Reviewed; 1408 AA.
AC Q1D7U3;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=MXAN_3077;
OS Myxococcus xanthus (strain DK1622).
OC Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC Cystobacterineae; Myxococcaceae; Myxococcus.
OX NCBI_TaxID=246197;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DK1622;
RX PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J.,
RA Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G.,
RA Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A.,
RA Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B.;
RT "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; CP000113; ABF90369.1; -; Genomic_DNA.
DR RefSeq; WP_011553127.1; NC_008095.1.
DR AlphaFoldDB; Q1D7U3; -.
DR SMR; Q1D7U3; -.
DR STRING; 246197.MXAN_3077; -.
DR EnsemblBacteria; ABF90369; ABF90369; MXAN_3077.
DR GeneID; 41360439; -.
DR KEGG; mxa:MXAN_3077; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_0_7; -.
DR OMA; FMTWEGY; -.
DR OrthoDB; 9601at2; -.
DR Proteomes; UP000002402; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1408
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000300356"
FT REGION 1383..1408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1408 AA; 157532 MW; 864B06F9E379B6ED CRC64;
MPTQIQNNFR VRKTFAKIAK IIDIPNLINI QKQSYEKFLQ ADIAADKRED LGLQGVFKSV
FPIRDFNETS SLEFVSYHLE RPKYDVDECH QRGMTYSAPI KVVVRLVVWD KDEETGAQSI
RDVKEQEVYF GEIPLMTQNG TFIINGTERV VVSQLHRSPG AFFDHDKGKS HSSGKLLYNA
RIIPYRGSWI DFEFDHKDLL YVRIDRRRKL PATVLIRALG AVPDTAKKNP LEFKGSTEEI
LNYYYATETI YLHSAEEFEK SVELELLPGQ RATRDIKAKT GELIVKKNRK FTRAAIKKLE
AAKMKTLPID ADELFTKVSA YDVVEETNGV VLLECNEEVT QEKVDELLKH GIKEFKVLFI
DNLNVGPYLR ETLMLDKLET PEQSIMEIYR RLRPGDPPTP ETAINLFTNL FFNPERYDLS
KVGRLKLNFK FGLEEPLDGQ ILTKRDILEV IRYLIDLKNG KGTIDDIDHL GNRRVRAVGE
LLENQYRIGL VRMERAIKER MSLQEIETLM PHDLINAKPV TAVIKEFFGS SQLSQFMDQT
NPLSEVTHKR RLSALGPGGL TRERAGFEVR DVHPTHYGRI CPIETPEGPN IGLIASLSTY
ARVNEFGFVE TPYRKVEAGV VTNDVAFYSA LEEEKHTIAQ ANAETDKKGK FANALVSSRR
GGEFVQARAE DVDLMDVSPK QLVSVAASLI PFLENDDANR ALMGSNMQRQ AVPLLRTAAP
LVGTGIESIV ARDSGVTCVA RRDGIVESVD AGRIVVKADV PASLSDVTSE VDIYNLLKYQ
RSNQNTCLNQ KPIISKGDRV MKGDVIADGP ATETGELALG QNVVVAFMPW QGYNFEDSIL
ISERILKDDV FTSIHIEEFE CIARDTKLGK EEITRDIPNV GEEALKDLDE SGIIRIGAEV
KPGDVLVGKI TPKGETQLSP EEKLLRAIFG EKAGDVRDSS LRVPPGVVGT VINAKVFSRK
GVEKDERAKQ IESMEEAKLL KDQNDEIKVL QDSAFGRIRG LVRTKEVQGK LVDDKGKILL
KKGDILDDEL LSTVPYKYWG EISVGDPLDS RLRDILRNLE ETKEAVKLAF GEKIARIKKG
DELPPGVIKM VKVYVAIKRK LAVGDKMAGR HGNKGVVSRI LPEEDMPYLE DGRPVDIVLN
PLGVPSRMNI GQILETHLGW AAKGTGEALQ RYVEANWSSD AIKERLKVIY SDPAFGEFLD
KLDDEEIKQL CLRSKRGIHV ATPVFDGAQE TEIHALLDEG QLPRSGQMVL FDGRTGEPFD
QNVTVGVMYM LKLHHLVDEK IHARSIGPYS LVTQQPLGGK AQFGGQRLGE MEVWAMEAYG
AAYTLQEFLT VKSDDVVGRT RMYEAIVKGD NVLESGLPES FNVLLKELQS LALDVELLES
APPERQRSFG GDFLGGGDGE ERKTGTEA
