RPOB_NOCSJ
ID RPOB_NOCSJ Reviewed; 1166 AA.
AC A1SEK1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=Noca_0711;
OS Nocardioides sp. (strain ATCC BAA-499 / JS614).
OC Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC Nocardioides.
OX NCBI_TaxID=196162;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-499 / JS614;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J.,
RA Richardson P.;
RT "Complete sequence of chromosome 1 of Nocardioides sp. JS614.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; CP000509; ABL80236.1; -; Genomic_DNA.
DR AlphaFoldDB; A1SEK1; -.
DR SMR; A1SEK1; -.
DR STRING; 196162.Noca_0711; -.
DR PRIDE; A1SEK1; -.
DR EnsemblBacteria; ABL80236; ABL80236; Noca_0711.
DR KEGG; nca:Noca_0711; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_1_11; -.
DR OMA; FMTWEGY; -.
DR Proteomes; UP000000640; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1166
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000300360"
SQ SEQUENCE 1166 AA; 129879 MW; B48270A50253C77A CRC64;
MQIEERIVEG HLLAARTTPG NTRRISFAKI TEPLEVPQLL SLQTDSFDWL VGNDKWNAAV
ERRRSEGEDV SSKSGLQEIF EEISPIEDFS ETMSLSFENP VFYDPKYTVD ECKEKDFTYS
APLYVSAEFT NNDTGEIKGQ TVFMGDFPLM TDKGTFIING TERVVVSQLV RSPGVYFERT
ADKTSDKDIY TAKLIPSRGA WLEFEIDKRD MVGVRLDRKR KQNVTVLLKA LGWTNEQIRE
EFGEYESMML TLEKDHTQGQ DDALLDIYRK LRPGEPPTRE AAQTLLNNYY FNPKRYDLAK
VGRYKINKKL GLLEAFDQQT LTIDDVVAAI KYIVALHDGR EQIEAPQGTL DISADDIDHF
GNRRMRTVGE LIQNQLRTGL ARMERVVRER MTTQDVEAIT PQSLINIRPV VAALKEFFGT
SQLSQFMDQT NPIAGLTHKR RLSALGPGGL SRDRAGMEVR DVHPSHYGRM CPIETPEGPN
IGLIGSLASY GRINPFGFVE TPYRKVTKGK VTDQIDYLTA DDEDRYVIAQ ANAALDDKSR
FVEERVLVRQ RDGEVSEVLA DEVDYMDVSP RQMVSVATAL IPFLEHDDAN RALMGANMQR
QAVPLIKSDS PLVGTGIEYR AAVDAGDVVV ATAAGVVKEV SADVIETMND DGTYSTYRLA
KFKRSNQGTC INQRPLVSEG DRLEIGTPIA DGPCTDEAEM ALGTNLLVAF MPWQGHNYED
AIILSQRLVQ EDILTSIHIE EHEVDARDTK LGPEEITRDI PNVSEEMLAD LDERGIIRIG
AEVTTGDVLV GKVTPKGETE LTPEERLLRA IFGEKAREVR DTSMKVPHGE SGTVIGVRVF
DREDGDELPP GVNQLVRVYV AQKRKISVGD KLAGRHGNKG VIAKILPIED MPFMEDGTPV
DVVLNPLGVP RRMNIGQILE LHLGWLAKQG WDLNLNDDKS GADWKQRLIK IHADKAEPGT
KVATPVFDGA REDEITGLLG STIPNRDGVR MIDNTGKASL FDGRSGEPFP EPVAVGYMYI
LKLHHLVDDK IHARSTGPYS MITQQPLGGK AQFGGQRFGE MEVWAMEAYG AAYALQELLT
IKSDDVPGRV KVYEAIVKGE NIPDSGIPES FKVLVKEMQS LCLNVEVLSQ DGTAIEMRDA
EEDVFRAAEE LGIDLSRREP SSVEEV
