RPOB_OCEIH
ID RPOB_OCEIH Reviewed; 1179 AA.
AC Q8ETY8;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=OB0112;
OS Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC
OS 3954 / HTE831).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX NCBI_TaxID=221109;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831;
RX PubMed=12235376; DOI=10.1093/nar/gkf526;
RA Takami H., Takaki Y., Uchiyama I.;
RT "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge
RT and its unexpected adaptive capabilities to extreme environments.";
RL Nucleic Acids Res. 30:3927-3935(2002).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; BA000028; BAC12068.1; -; Genomic_DNA.
DR RefSeq; WP_011064515.1; NC_004193.1.
DR AlphaFoldDB; Q8ETY8; -.
DR SMR; Q8ETY8; -.
DR STRING; 221109.22775790; -.
DR PRIDE; Q8ETY8; -.
DR EnsemblBacteria; BAC12068; BAC12068; BAC12068.
DR KEGG; oih:OB0112; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_0_9; -.
DR OMA; FMTWEGY; -.
DR OrthoDB; 9601at2; -.
DR PhylomeDB; Q8ETY8; -.
DR Proteomes; UP000000822; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1179
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000047932"
SQ SEQUENCE 1179 AA; 132269 MW; 312D442EF02EAFAF CRC64;
MTGQLVQYGR HRQRRSYARI NEVLELPNLI EIQTASYDWF LEEGLREMFQ DISPIEDFTG
NLSLEFVDYS LGDPKYPVDE AKERDVTYNA PLRVKVRLIN NETGEVKEQE VFMGDFPLMT
ETGTFIINGA ERVIVSQLVR SPSVYYNEKI DKNGKRGIGA TVIPNRGAWL EFETDAKDIA
YVRIDRTRKL PITVLLRALG FGTDQEITDL LGENEYLRNT LEKDNTENAE KALLEIYERL
RPGEPPTVEN AKSLLVSRFF DPKRYDLAHV GRYKMNKKLH MKNRLFNQIL AEPIVDPETG
EVIAEKGEKL ERKLLDKILP YLERAEDRFG ESVLSPHEGV LEDEITIQSV KIIDPTDPNG
ERELTVIGNG GVTNDVKNIT PADILSSISY FFNLLHEVGG TDDIDHLGNR RLRSVGELLQ
NQFRIGLSRM ERVVRERMSI QDTSSVTPQQ LINIRPVIAS IKEFFGSSQL SQFMDQTNPL
GELTHKRRLS ALGPGGLTRE RAGFEVRDVH YSHYGRMCPI ETPEGPNIGL INSLSSYAKV
NKFGFIESPY RRVDPETGKV TNKIDYLTAD EQDNYIVAQA NSPLDEDSRF QNEEVISRFQ
EDNIVVSRDK IDYMDVSPKQ VVSAATACIP FLENDDSNRA LMGANMQRQA VPLMKPQAPI
VGTGMEYVNG KDSGAAVICH HDGVIERVEA KEVYVRRISI VDGKEVEGDL DRYGLQKYKR
SNQGTCYNQR PIVSQGDRVT KGEVLADGPS MEDGELALGQ NVLVGFMTWE GYNYEDAIIM
SERLVKDDVY TSIHIEEFES EARDTKLGPE EITRDIPNVG EDALKNLDEH GIIRVGAEVT
DGDILVGKVT PKGVTELSAE ERLLHAIFGE KAREVRDTSL RVPHGGGGIV LDVKIFNRED
GDELPPGVNQ LVRAYIVQKR KIHEGDKMAG RHGNKGVISK ILPEEDMPYL PDGTPIDIML
NPLGVPSRMN IGQVFELHLG MAARQLGIHV ASPVFDGARE EDVWETLEEA GMPRDAKTVL
YDGRTGEAFD NRVSVGVMYM IKLAHMVDDK LHARSTGPYS LVTQQPLGGK AQFGGQRFGE
MEVWALEAYG AAYTLQEILT VKSDDTVGRV KTYEAIVKGD NVPEPGVPES FKVLIKELQS
LGMDVKMLSS NEDEIDMREL EEEEVQAATK LNIDVEESE
