ID   RPOB_PARD8              Reviewed;        1270 AA.
AC   A6LE81;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN   Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=BDI_2264;
OS   Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM
OS   5825 / NCTC 11152).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Tannerellaceae;
OC   Parabacteroides.
OX   NCBI_TaxID=435591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152;
RX   PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA   Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA   Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA   Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA   Knight R.D., Gordon J.I.;
RT   "Evolution of symbiotic bacteria in the distal human intestine.";
RL   PLoS Biol. 5:1574-1586(2007).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC   -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC       and 1 omega subunit. When a sigma factor is associated with the core
CC       the holoenzyme is formed, which can initiate transcription.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR   EMBL; CP000140; ABR43995.1; -; Genomic_DNA.
DR   RefSeq; WP_005854221.1; NZ_LR215978.1.
DR   AlphaFoldDB; A6LE81; -.
DR   SMR; A6LE81; -.
DR   STRING; 435591.BDI_2264; -.
DR   EnsemblBacteria; ABR43995; ABR43995; BDI_2264.
DR   GeneID; 57235247; -.
DR   KEGG; pdi:BDI_2264; -.
DR   eggNOG; COG0085; Bacteria.
DR   HOGENOM; CLU_000524_4_3_10; -.
DR   OMA; FMTWEGY; -.
DR   OrthoDB; 9601at2; -.
DR   BioCyc; PDIS435591:G1G5A-2327-MON; -.
DR   Proteomes; UP000000566; Chromosome.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00653; RNA_pol_B_RPB2; 1.
DR   Gene3D; 2.30.150.10; -; 1.
DR   Gene3D; 2.40.270.10; -; 3.
DR   Gene3D; 2.40.50.150; -; 1.
DR   Gene3D; 3.90.1110.10; -; 2.
DR   HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR   InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR   InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR   InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR   InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR   InterPro; IPR010243; RNA_pol_bsu_bac.
DR   InterPro; IPR007121; RNA_pol_bsu_CS.
DR   InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR   InterPro; IPR007642; RNA_pol_Rpb2_2.
DR   InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR   InterPro; IPR007645; RNA_pol_Rpb2_3.
DR   InterPro; IPR007641; RNA_pol_Rpb2_7.
DR   InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR   PANTHER; PTHR20856; PTHR20856; 1.
DR   Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR   Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR   Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR   Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR   Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR   Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR   TIGRFAMs; TIGR02013; rpoB; 1.
DR   PROSITE; PS01166; RNA_POL_BETA; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transcription; Transferase.
FT   CHAIN           1..1270
FT                   /note="DNA-directed RNA polymerase subunit beta"
FT                   /id="PRO_0000300363"
SQ   SEQUENCE   1270 AA;  142995 MW;  FE7598535B306792 CRC64;
     MSSTAENQRV NFASIKNQFP YPDFLEVQLK SFQDFLQLDT PPEKRKKEGL YKVFAENFPI
     ADTRNNFVLE FLDYYIDPPR YCIDECIARG LTYSVPLKAK LKLYCTDPDH EDFDTVIQDV
     YLGPIPYMTD RGTFVINGAE RVVVSQLHRS PGVFFGQSTH ANGTKLYSAR IIPFKGSWIE
     FATDINNVMY AYIDRKKKLP VTTLLRAIGF ESDRDILEIF NLAEEVKVTK ANLKKFIGRK
     LAARVLKTWV EDFVDEDTGE VVSIERNDVI IDRESVLDSD NIEAILDSGT QNILLHREDQ
     NLSDYAIIYN TLQKDPSNSE KEAVLYIYRQ LRNAEPADEA SAREVITNLF FSEKRYDLGE
     VGRYRINKKL GLTTSADVKV LTKEDIIEII KYLIELINSK AIVDDIDHLS NRRVRTVGEQ
     LYNQFGIGLA RMSRTVRERM NVRDNEVFTP IDLINAKTIS SVVNSFFGTN ALSQFMDQTN
     PLAEITHKRR LSALGPGGLS RERAGFEVRD VHYTHYGRLC PIETPEGPNI GLISSLCVYA
     KINDLGFIST PYRKVADGKV DFSEEGLQYY TAEEEEELTI AQGNAPLDDN GKFIRDKVKA
     RFEADFPVVP PSEIDLMDVA PQQIASIAAS LIPFLEHDDA NRALMGSNMM RQAVPLLRTD
     APIVGTGIEA QVARDSRTQI MAEREGEVVF VDATCIKIKY DRTEDEEFVS FEDAVKTYNI
     PKWRKTNQST TVDLKPTCHR GQRVKAGDIL TEGYSTQKGE LALGRNVKVA YMPWKGYNYE
     DAIVLNERMV REDFFTSVHV DEYILEVRET KRGMEELTSD IPNVSEEATK DLDERGIVRV
     GARIEPGDIL IGKITPKGES DPSPEEKLLR AIFGDKAGDV KDASLKATPS LRGVVIETAL
     FSKAVKKRKS RLTDKAILPK LDEEYEEKMA SLKTLLVDKL LVLTNGKVSQ GVKDYMNTEI
     IAKGAKFTRK SLEELDYNSI QVSKWTADAQ KNELIKQVIL NYLKKYKELD AELRRKKFDL
     TIGDELPTGI VQMAKVYIAK KRKIQVGDKM AGRHGNKGIV SKIVRQEDMP FLEDGTPVDI
     CLNPLGVPSR MNLGQIFEAV LGWAGRELDV KFATPIFDGA TLDDLNEWTD KAGIPRYGKS
     YLYDGGTGER FDQPATVGVT YFLKLGHMVD DKMHARSIGP YSLITQQPLG GKAQFGGQRF
     GEMEVWALEA FGAAHVLQEI LTIKSDDVVG RSKAYEAIVK GDPMPQPGIP ESLNVLLHEL
     RGLGLSFTLD