RPOB_PARDP
ID RPOB_PARDP Reviewed; 1382 AA.
AC A1B015;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=Pden_0747;
OS Paracoccus denitrificans (strain Pd 1222).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC Rhodobacteraceae; Paracoccus.
OX NCBI_TaxID=318586;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pd 1222;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Spiro S.,
RA Richardson D.J., Moir J.W.B., Ferguson S.J., van Spanning R.J.M.,
RA Richardson P.;
RT "Complete sequence of chromosome 1 of Paracoccus denitrificans PD1222.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000489; ABL68859.1; -; Genomic_DNA.
DR RefSeq; WP_011747092.1; NC_008686.1.
DR AlphaFoldDB; A1B015; -.
DR SMR; A1B015; -.
DR STRING; 318586.Pden_0747; -.
DR PRIDE; A1B015; -.
DR EnsemblBacteria; ABL68859; ABL68859; Pden_0747.
DR KEGG; pde:Pden_0747; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_0_5; -.
DR OMA; FMTWEGY; -.
DR Proteomes; UP000000361; Chromosome 1.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1382
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000300364"
SQ SEQUENCE 1382 AA; 153614 MW; 0FC273FC27CA57BA CRC64;
MAQAYVGQKR IRRYYGNIRE VLEMPNLIEV QKSSYDLFLR SGDAEGHQDG EGIQGVFQSV
FPIKDFNETA TLEFVKYELE KPKYDVEECQ SRDMTYAAPL KVTLRLIVFD VDETTGAKSV
KDIKEQDVYM GDMPLMTQNG TFIVNGTERV VVSQMHRSPG VFFDHDRGKT HSSGKLLFAC
RIIPYRGSWL DFEFDAKDLV FARIDRRRKL PVTTLLYALG MDQEGIMDAF YNTVDYKLQR
AGKGQAAGWV TKFFPERVRG TRPSFDLVNA ETGEIITKAG DKVTPRLVKQ LAEKGDINLL
LPFEKIVGRF VAKDIINEQT GLIYAEAGDE ITVEYDRDGE ISGGLLKVLL DNGIEDIPVL
DIDHVNVGPY IRNTMAADKN MSRDGALMDI YRVMRPGEPP TVEAASALFD SLFFDSERYD
LSAVGRVKMN MRLDLDAPDT QRTLRKEDII ACIRGLVELR DGKGEIDDID HLGNRRVRSV
GELMENQYRI GLLRMERAIR ERMSGVEIDT VMPQDLINAK PAAAAVREFF GSSQLSQFMD
QTNPLSEVTD KRRLSALGPG GLTRERAGFE VRDVHPTHYG RMCPIETPEG QNIGLINSLA
TFARVNKYGF IETPYRKVVE GKVTDEVVYM SATEEMRHTI AQANATLDES GKFVDELVST
RQAGDFMLNP VEAVDLIDVS PKQLVSVAAA LIPFLENDDA NRALMGSNMQ RQAVPLLRAE
APFVGTGMEA TVARDSGAAI MARRGGIIDQ VDAQRIVIRA TEDLGAGDAG VDIYRLRKFK
RSNQSSTINQ RPLVKVGDKV VKGQVVADGP STDQGELAIG RNVVVAFMPW NGYNYEDSIL
ISERIHRDDV FTSIHIDEYE VAARDTKLGP EEITRDIPNV GEEALRNLDE AGIVYIGAEV
GPGDILVGKI TPKGESPMTP EEKLLRAIFG EKASDVRDTS LRLPPGAYGT IVEVRVFNRH
GVDKDERALQ IEREEVERLA RDRDDELAIL ERNIYARLKS LIMGKEVVKG PKGIRAGAVV
DEDLLGQLSR GQWWQLAVAD EDTAKEVEAL NQQFDAQKRA LDNRFDDKVE KVRQGDDLPP
GVMKMVKVFV AVKRKLQAGD KMAGRHGNKG VVSKVVPIED MPFLSDGTPV DLVFNPLGVP
SRMNVGQILE THMGWASRGL GIKIDEALQD YRRNGDMTPV REAMQNGYGD DFYAETFEGM
EDETLLEHAD AVRGGVPIST PVFDGAKEAD INDALRRAGF DTSGQSIVFD GRTGEQFARP
VTVGMKYVLK LHHLVDDKMH ARSTGPYSLV TQQPLGGKAQ FGGQRLGEME VWALEAYGAA
YTLQEMLTVK SDDVAGRTKV YESIVKGEDN FEAGVPESFN VLVKEVRGLG LNMELLDAED
EE
