RPOB_PHOPR
ID RPOB_PHOPR Reviewed; 1341 AA.
AC Q6LLW2;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=PBPRA3432;
OS Photobacterium profundum (strain SS9).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Photobacterium.
OX NCBI_TaxID=298386;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1253 / SS9;
RX PubMed=15746425; DOI=10.1126/science.1103341;
RA Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M.,
RA Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C.,
RA Bartlett D.H., Valle G.;
RT "Life at depth: Photobacterium profundum genome sequence and expression
RT analysis.";
RL Science 307:1459-1461(2005).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; CR378674; CAG21716.1; -; Genomic_DNA.
DR RefSeq; WP_011219958.1; NC_006370.1.
DR AlphaFoldDB; Q6LLW2; -.
DR SMR; Q6LLW2; -.
DR STRING; 298386.PBPRA3432; -.
DR PRIDE; Q6LLW2; -.
DR EnsemblBacteria; CAG21716; CAG21716; PBPRA3432.
DR KEGG; ppr:PBPRA3432; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_0_6; -.
DR OMA; FMTWEGY; -.
DR OrthoDB; 9601at2; -.
DR Proteomes; UP000000593; Chromosome 1.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1341
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000224090"
SQ SEQUENCE 1341 AA; 149774 MW; 1D40CB3E592E7CA1 CRC64;
MVYSYTEKKR IRKDFGKRPR VLDAPYLLSI QLDSFKKFIE QDPEGHYGLE AAFRSVFPIQ
SYNGNSELQY VSYRLGEPVF DVKECQIRGV TYSAPLRVKL RLVMYDKDAP AGTVKDIKEQ
EVYMGEIPLM TDNGTFVING TERVIVSQLH RSPGVFFDSD KGKTHSSGKV LYNARVIPYR
GSWLDFEFDP KDNVFVRIDR RRKLAASVIL RALDYTTEQI LDMFFDKVSF EVQGKSLVME
LVPERLRGET ASFDIEANGK VYVEQGRRIT ARHIRQLGKD GVDQIEVPVE YIVGKISSRD
YVNEETGELI AAANQELNLE ILALLSQAGH KSIEVLFTND LDYGPYMSET LRVDSTTDRL
SALVEIYRMM RPGEPPTREA AEQLFNSLFF SEDRYDLSAV GRMKFNSSLL REETTGSGIL
DHSDIIEVMK KLIEIRNGRG EVDDIDHLGN RRIRSVGEMA ENQFRVGLVR VERAVKERLS
LGDLDAIMPQ DLINAKPISA AVKEFFGSSQ LSQFMDQNNP LSEVTHKRRI SALGPGGLTR
ERAGFEVRDV HATHYGRLCP IETPEGPNIG LINSLSVYAR CNSYGFLETP YRKVVDSKVT
DQIDYLSAIE EGQYVIAQAN AALETDGSFS DELITARQKG DSGLHPRDHV QYMDVATNQV
VSVAASLIPF LEHDDANRAL MGANMQRQAV PTLRADKPLV GTGIERSVAV DSGVTAVAKR
GGQVQSVDAS RIVVKVNEDE LVPGEAGIDI YNLTKYTRSN QNTCINQRPT VMPGEPVARG
DVLADGPSTD LGELALGQNI RIAFMPWNGY NFEDSILVSE RVVQQDRLTT IHIQELSCVA
RDTKLGSEEI TADIPNVGEA ALSKLDESGI VYIGAEVKGG DILVGKVTPK GETQLTPEEK
LLRAIFGEKA SDVKDSSLRV PNSVSGTIID VQVFTRDGVE KDKRALEIEE MQLKEAKKDI
TEEFQILEGG LLARVRTLLL SIGYSEEKIA SMDRERLFAL TLDDESLQNQ LEQLAEQYDE
LKAEFDKKFE TKRRKITQGD DLAPGVLKIV KVYLAVKRRI QPGDKMAGRH GNKGVISKIC
PVEDMPYDEK GQTVEIVLNP LGVPSRMNIG QILETHMGLA AKGIGDKLNE MLKQQQELHK
FRNFLQKVYD LGDTRQDVDI AALSDDQVHT LVQNLRDGLP IATPVFDGAP ESSIKELLKL
GDLPESGQLK MFDGRTGDMF ERPVTVGYMY MLKLNHLVDD KMHARSTGSY SLVTQQPLGG
KAQFGGQRFG EMEVWALEAY GAAFTLQEML TVKSDDVNGR TKMYKNIVDG DHRMEPGMPE
SFNVLLKEIR SLGINIELED K
