RPOB_PHOV8
ID RPOB_PHOV8 Reviewed; 1270 AA.
AC A6KYK3;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=BVU_0813;
OS Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 /
OS NBRC 14291 / NCTC 11154) (Bacteroides vulgatus).
OC Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Phocaeicola.
OX NCBI_TaxID=435590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC
RC 11154;
RX PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA Knight R.D., Gordon J.I.;
RT "Evolution of symbiotic bacteria in the distal human intestine.";
RL PLoS Biol. 5:1574-1586(2007).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; CP000139; ABR38517.1; -; Genomic_DNA.
DR RefSeq; WP_005844834.1; NC_009614.1.
DR AlphaFoldDB; A6KYK3; -.
DR SMR; A6KYK3; -.
DR STRING; 435590.BVU_0813; -.
DR EnsemblBacteria; ABR38517; ABR38517; BVU_0813.
DR GeneID; 66751850; -.
DR KEGG; bvu:BVU_0813; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_1_10; -.
DR OMA; FMTWEGY; -.
DR OrthoDB; 9601at2; -.
DR BioCyc; BVUL435590:G1G59-855-MON; -.
DR Proteomes; UP000002861; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 2.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1270
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000300281"
SQ SEQUENCE 1270 AA; 142485 MW; B08E5C27D60D76F6 CRC64;
MSSNTENQRV NFASIKNPMK YPDFLEVQLK SFQDFLQLDT PPEKRKNDGL YKVFAENFPI
ADTRNNFVLE FLDYYIDPPH YSIDECLERG LTYSVPLKAK LKLYCTDPDH EDFDTVIQDV
YLGPIPYMTP KGTFVINGAE RVVVSQLHRS PGVFFGQSVH ANGTKLYSAR IIPFKGSWIE
FATDINNVMY AYIDRKKKLP VTTLLRAVGF ENDKDILEIF NLAEDVKVNK TNLKKVVGRK
LAARVLKTWT EDFVDEDTGE VVSIERNEVI IDRETVIEED HIDEIIDSGV QNILVHKEEA
NSSDYSIIFN TLQKDPSNSE KEAVLYIYRQ LRNADPADDA SAREVINNLF FSEKRYDLGE
VGRYRINKKL GLTTDMDVKV LTKQDIIEII KYLIELINSK ADVDDIDHLS NRRVRTVGEQ
LSNQFAIGLA RMSRTIRERM NVRDNEVFTP IDLINAKTIS SVINSFFGTN ALSQFMDQTN
PLAEITHKRR LSALGPGGLS RERAGFEVRD VHYTHYGRLC PIETPEGPNI GLISSLCVYA
KINELGFIST PYRKVADGKV DISDEGIEYL TAEEEEDKII AQGNAPLDDE GKFVREKVKA
RRDADYPVVT PDQVELMDVS PQQIASIAAS LIPFLEHDDA NRALMGSNMM RQAVPLLRTE
APIVGTGIEK QLVEDSRTQI AAEGDGVVEY VDATTIRILY DRNEDEEFVS FEPALKEYRI
PKFRKTNQSM TIDLRPTCDK GQRVKKGDIL TEGYSTQGGE LALGKNLLVA YMPWKGYNYE
DAIVLNERVV REDLLTSVHV DEYILEVRET KRGMEELTSD IPNVSEEATK DLDENGIVRV
GARIEPGDIL IGKITPKGES DPSPEEKLLR AIFGDKAGDV KDASLKASPS LRGVVIDKKL
FSRVIKSRSE KNADKAILPK LNDEFEEKAA KLKDILIEKL LVLTNGKVSQ GVKDYLGTEV
IAKGAKFTKR DLESLDYTII QLSKWTADAH KNDMIRDLVM NYLKKYKELD AELKRKKFAI
TIGDELPAGI IQMAKVYIAK KRKIGVGDKM AGRHGNKGIV SRVVRQEDMP FLADGTPVDI
VLNPLGVPSR MNIGQIFEAV LGRAGKELGV KFATPIFDGA SMDDLNEWTD KAGLPRYCKT
YLCDGGTGER FDQPATVGVT YMLKLGHMVE DKMHARSIGP YSLITQQPLG GKAQFGGQRF
GEMEVWALEA FGAAHILQEI LTIKSDDVVG RSKAYEAIVK GEPMPTPGIP ESLNVLLHEL
RGLGLSINLE
