RPOB_PORG3
ID RPOB_PORG3 Reviewed; 1269 AA.
AC B2RL45;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=PGN_1571;
OS Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM
OS 12257 / NCTC 11834 / 2561).
OC Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC Porphyromonas.
OX NCBI_TaxID=431947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561;
RX PubMed=18524787; DOI=10.1093/dnares/dsn013;
RA Naito M., Hirakawa H., Yamashita A., Ohara N., Shoji M., Yukitake H.,
RA Nakayama K., Toh H., Yoshimura F., Kuhara S., Hattori M., Hayashi T.,
RA Nakayama K.;
RT "Determination of the genome sequence of Porphyromonas gingivalis strain
RT ATCC 33277 and genomic comparison with strain W83 revealed extensive genome
RT rearrangements in P. gingivalis.";
RL DNA Res. 15:215-225(2008).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; AP009380; BAG34090.1; -; Genomic_DNA.
DR RefSeq; WP_012458381.1; NZ_CP025930.1.
DR AlphaFoldDB; B2RL45; -.
DR SMR; B2RL45; -.
DR STRING; 431947.PGN_1571; -.
DR PRIDE; B2RL45; -.
DR EnsemblBacteria; BAG34090; BAG34090; PGN_1571.
DR GeneID; 29256745; -.
DR KEGG; pgn:PGN_1571; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_3_10; -.
DR OMA; FMTWEGY; -.
DR BioCyc; PGIN431947:G1G2V-1771-MON; -.
DR Proteomes; UP000008842; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 2.
DR Gene3D; 2.40.50.150; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription;
KW Transferase.
FT CHAIN 1..1269
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_1000141719"
SQ SEQUENCE 1269 AA; 142381 MW; 56C53DEBA1A056B6 CRC64;
MTPTTNNKRI NFASIKNPLF YPDFLEVQLK SFHDFLQLDT PPERRKKEGL YKVFAENFPI
TDTRNNFVLE FLDYYIDPPK YSIEECLSRG LTYSVPLKAK LKLYCTDPDH EDFATVIQDV
FLGPIPYMTS SGTFVINGAE RVIVSQLHRS PGVFFGQSLH TNGTKLYSAR IIPFKGSWIE
FATDINNVMY AYIDRKKKLP VTTLLRAIGF EADKDILDIF NLAEEVKVTK ANLKKCIGRK
LAARVINTYI DDLSDEDTGE VVSMERITVV VDREVELTED NIEAILNSNT QTILLHRNDS
NTSDYSIIFN TLQKDPCNSE KEALYYVYRQ LRNAEPADDA SAREVITNLF FSDKRYDLGD
VGRYRINKKL NLNIDPDIKV LTNEDIIEII KYLIELVNSK ASVDDIDHLS NRRVRTVGEQ
LYNQFGIGLA RMARTVRDRM NVRDNEVFTP IDLVNAKTIS SVVNSFFGTN ALSQFMDQTN
PLAEITHKRR LSALGPGGLS RERAGFEVRD VHYTHYGRLC PIETPEGPNI GLISSLCVYA
KISDLGFITT PYREVKNGKV DFSDNGLKYY TAEEEEEKTV AQGNAPLDEN GRFVRERVKA
RYESDFPLVT PDEVDLMDVS PTQIASIAAA LIPFLEHDDA NRALMGSNMM RQAVPLLRPE
SPIVGTGIEG KLVKDSRTQI VAERGGEVVF VDASCIKIRY DRTADEEFVS FDDAIVTYYL
PKYRKTNQST TIDLHPICSK GDRVEAGQIL TEGYSTQGGE LALGRNVQVA YMPWKGYNYE
DAIVLNERMV REDFFTSVHV DEYILEVRET KRGLEELTSD IPNVSEDATR DLDENGIVRI
GAHIEPGDIL IGKITPKGES DPTPEEKLLR AIFGDKAGDV KDASLKATPS LRGVVIDTKL
FSKAAKKKSR TSTKETVSKL DETYAKRQQQ LHERLIEKLT ELTKGKTCCG VKDYLNVELI
KAGSKLTKKD LEALDFNVIQ LSDWTNDAHT NELIKAVAVN YLKHSKEIEA ELRRRKLDET
IGDELPAGIV QMAKVYIAKK RKIQVGDKMA GRHGNKGIVS KIVRQEDMPF LADGTPVDIC
LNPLGVPSRM NLGQIFEAVL AWAGRKMNVK FATPIFDGAS LNDMNEWTDK AGLPRDGKTY
LYDGGTGERF DQPATVGVTY FLKLGHMVDD KMHARSIGPY SLITQQPLGG KAQFGGQRFG
EMEVWALEAF GASHILQEIL TVKSDDVVGR SKAYEAIVKG DPMPTPGIPE SLNVLLHELK
GLGLSFSLD
