ID   ATRIP_MACFA             Reviewed;         655 AA.
AC   Q9N077;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2004, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=ATR-interacting protein;
DE   AltName: Full=ATM and Rad3-related-interacting protein;
DE   Flags: Fragment;
GN   Name=ATRIP; ORFNames=QccE-12377;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for checkpoint signaling after DNA damage. Required
CC       for ATR expression, possibly by stabilizing the protein (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with ATR. The heterodimer binds the RPA complex
CC       and is then recruited to single-stranded DNA. Interacts with CEP164
CC       (via N-terminus). Interacts with CINP (By similarity). Interacts with
CC       ATR (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Redistributes to
CC       discrete nuclear foci upon DNA damage. {ECO:0000250}.
CC   -!- DOMAIN: The EEXXXDDL motif is required for the interaction with
CC       catalytic subunit PRKDC and its recruitment to sites of DNA damage.
CC       {ECO:0000250}.
CC   -!- PTM: Phosphorylated by ATR. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATRIP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB01636.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB046054; BAB01636.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q9N077; -.
DR   SMR; Q9N077; -.
DR   STRING; 9541.XP_005547077.1; -.
DR   eggNOG; ENOG502QQF4; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; ISS:UniProtKB.
DR   GO; GO:0000077; P:DNA damage checkpoint signaling; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   InterPro; IPR033349; ATRIP.
DR   PANTHER; PTHR28594; PTHR28594; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; DNA damage; DNA repair; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           <1..655
FT                   /note="ATR-interacting protein"
FT                   /id="PRO_0000064741"
FT   REGION          120..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          307..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          6..82
FT                   /evidence="ECO:0000255"
FT   MOTIF           633..640
FT                   /note="EEXXXDL motif"
FT   COMPBIAS        137..157
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        312..327
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   655 AA;  71383 MW;  6FB37F35280154E1 CRC64;
     LIKNGEIKIL RDSLHQTESV LEEQRRSHFL LEQEKTQALS DKEKEFSKKL QSLQSELQFK
     DAEMNELRTK LQTSERANKL AAPSVSHVSP RKNPSVVIKP EACSPQFGKT SFPTKESFSA
     NMSLPHPCQT ESGYKPLVGR EDSKTHSLRG DSIKQEEAQK SFVDSWRQRS NTQGSILINL
     LLKQPLIPGS SLSLCHLLSS SSESPAGTPL QPPGFGSTLA GMSGLRTTGS QDGSFSLSAL
     REAQNLAFTG LNLVARNECS RDGDPAEGGR RAFPLCQLPG AVHFLPLVQF FIGLHCQALQ
     DLAAAKRSGA PGDSPTHSSR VSSGVETNPE DSVRILEGFS VTALSILQHL VCHSGAVVSL
     LLSRVGADSA AGEGNGSLVH RFSDGDMTSA PRGVADDQGQ HPLLKMLLHL LAFSSAATGH
     LQASVLTQCL KVLVKLAENT SSDFLPRFQC VFQVLPKCLS PETPLPGMVL AVELLSLLAD
     HDQLAPQLCS HSDCLLLLLY MYITSRPDRV ASETQWLQLE QEVVWLLSKL GVQSPLPLVT
     GSNCQCNVEV VRALTVMLHR QWLTVRRAGG PPRTDQQRRT VRCLRDTVLL LHGLSQKDKL
     FIMHCVEVLH QYDQVMPGVS MLIRGLPDVT DCEEAALDDL CAAETDVDDP ELECG