RPOB_RENSM
ID RPOB_RENSM Reviewed; 1175 AA.
AC A9WSY0;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321};
GN OrderedLocusNames=RSal33209_2186;
OS Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 /
OS NBRC 15589 / NCIMB 2235).
OC Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Renibacterium.
OX NCBI_TaxID=288705;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235;
RX PubMed=18723615; DOI=10.1128/jb.00721-08;
RA Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S.,
RA Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H.,
RA Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.;
RT "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests
RT reductive evolution away from an environmental Arthrobacter ancestor.";
RL J. Bacteriol. 190:6970-6982(2008).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; CP000910; ABY23918.1; -; Genomic_DNA.
DR AlphaFoldDB; A9WSY0; -.
DR SMR; A9WSY0; -.
DR STRING; 288705.RSal33209_2186; -.
DR EnsemblBacteria; ABY23918; ABY23918; RSal33209_2186.
DR KEGG; rsa:RSal33209_2186; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_1_11; -.
DR OMA; FMTWEGY; -.
DR Proteomes; UP000002007; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1175
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_1000086378"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1175 AA; 129264 MW; C58DB745BC502B5C CRC64;
MEGSLLVASS ASNNETANNV ESTDGATRRI SFAKIHEPLD VPNLLALQTE SFDWLVGNGR
WQDRMQKAVD AGDESVATTS GLSDIFEEIS PIEDFQGTMS LSFSEPEFAD PKYTMAECKD
RDATFSAPLY VKAEFMNNNT GEIKQQTVFM GDFPLMTEKG TFVINGTERV VVSQLVRSPG
AYFERTADKT SDKDIFTAKI IPSRGAWFEL EIDKRDQVGV RLDRKRKQSV TVLLKALGWT
ESQILEEFGE FDSIRATLEK DGTSTREDAL LDIYRKLRPG EPPTVEAAQT LLDNLYFNPK
RYDLAKVGRY KINRKLGIDK SLASPDASVL DINDIVAIIK FLVTLHAGGK SLTAKRDGKD
FELRVDVDDI DHFGNRRIRA VGELIENQVR TGLSRMERVV RERMTTQDVE AITPQTLINI
RPVVAAIKEF FGTSQLSQFM DQNNPLAGLT HKRRLSALGP GGLSRDRAGY EVRDVHPSHY
GRMCPIETPE GPNIGLIGSL ASYGRINPLG FIETPYRKVS KGHVSDEVDY LTADDELNYI
IAQANAPLDS KSSFVEDQVL VRQRGGGGEP VLVAADDVEY MDVSPRQMVS VATALIPFLE
HDDANRALMG ANMQRQAVPL VRSEAPVVGT GMERAAAVDA GDVVIAKKAG VVTEVSADLV
IMLNDDGTET NYRIAKYNRS NQGTAYNQRV LVSEGARLEV GGIIADGPAT DQGELALGKN
LLVAFMSWEG HNFEDAIILS QRLVSEDVLS SIHIEEHEID ARDTKLGAEE ITRDIPNVSE
EILAGLDERG IIHIGAEVDA GDILVGKVTP KGETELTPEE RLLRAIFGDK SGEVRDTSLK
VPHGESGTVI GVRFFDREND DDLAPGVNQL VRIYVAAKRK ITNGDKLAGR HGNKGVISKI
LPIEDMPFLA DGTPVDIVLN PLGVPGRMNV GQVLELHLGW IAKTGWKIDG EPDWVKNLPN
LPRETGRDQI LATPVFDGAR EEEISGLLDS TNVTRDGDLL INRSGKTRLF DGRSGEPFPD
PISVGYMYIL KLHHLVDDKI HARSTGPYSM ITQQPLGGKA QFGGQRFGEM EVWALEAYGA
AYTLQELLTI KSDDIHGRVK VYEAIVKGEN IPEPGIPESF KVLIKEMRSL CLNVEVLSTE
GSTIEMRDSD EEVFRAAEEL GIDLSRAEPN SVEEV
