RPOB_RUBXD
ID RPOB_RUBXD Reviewed; 1141 AA.
AC Q1AU22;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=Rxyl_2162;
OS Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129 / PRD-1).
OC Bacteria; Actinobacteria; Rubrobacteria; Rubrobacterales; Rubrobacteraceae;
OC Rubrobacter.
OX NCBI_TaxID=266117;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 9941 / NBRC 16129 / PRD-1;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., da Costa M.S.,
RA Rainey F.A., Empadinhas N., Jolivet E., Battista J.R., Richardson P.;
RT "Complete sequence of Rubrobacter xylanophilus DSM 9941.";
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; CP000386; ABG05106.1; -; Genomic_DNA.
DR RefSeq; WP_011565121.1; NC_008148.1.
DR AlphaFoldDB; Q1AU22; -.
DR SMR; Q1AU22; -.
DR STRING; 266117.Rxyl_2162; -.
DR PRIDE; Q1AU22; -.
DR EnsemblBacteria; ABG05106; ABG05106; Rxyl_2162.
DR KEGG; rxy:Rxyl_2162; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_3_11; -.
DR OMA; FMTWEGY; -.
DR OrthoDB; 9601at2; -.
DR PhylomeDB; Q1AU22; -.
DR Proteomes; UP000006637; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 2.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1141
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000300392"
FT REGION 1117..1141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1141 AA; 127103 MW; 26B93ECE15AD5429 CRC64;
MRVRPFFNDS SWRRANLVTP IVRRKRHSYA RLQSADAQLP NLIQIQLSSF QKFMDEGIRR
TLEDISPIED YSGSYAVEFG EHRFEEPPVS IEECMSKDKT YAAPLFVRVR FVIKETGEVR
EQDVFMGDFP LMTDWGTFII NGTERVVVTQ LVRSPGAYVM EPKDPTKQVL TASLMPHRGS
WLEFEVETKG YVSVRIDRKR KLPVTVLLKA LGFGGPEEIL ARFGNSWLIR NTLERDDTTS
REDALLEVFR RQRPGEPVNL ENAQNLVDGL FFDPKRYDLS EVGRYKVNKK LRLDVPRDVH
TLTIEDIEGL LRRLLGIAEE VAEEEEFGRI NYERIRHKLD EYEHFGNRRL RTVGELVQEA
FRIGMYRMER VVRERMTTQD EESITPQTVV NTKPVASAIK EFFGSSQLSQ FMDQTNTLAG
LSHRRRLNAM GAGGLSRERA PIEVRDVHPT HYGRMCPIET PEGPNIGLIG QLSTFARVNE
YGFVQTPYRK VEDGRVTDEV EYLSADEEEE YTIAQANTPV DLETGRITAE TVLARSRGGD
VTTVSPEEVD YMDVSPVQTV SVATSLIPFL EHDDANRALM GANMQRQAVP LLRSEAPYVG
TGMEFRAATD TGDVLLARNA GTVERVTASR IVVRREDGGL DEYALRKFAR SNQGTCVNQR
PLVKEGEEVE AGTVLADGSS TDQGELALGK NLLVAFMPWE GYNFEDAIII SERLVKEDVL
TSIHIEEYEV QARDTKLGPE EITRDIPHAS DDVLMNLDAD GIIRIGAEVS SGDVLVGKVT
PKGESEPTPE EKLLRAIFGE KAREVKDSSL KVPHGEGGVV IDVKRFSREA GDDLPPGVNE
MVRVFVATKR KIAEGDKLAG RHGNKGVISK IVPEEDMPFM EDGTPVDVIL SPLGVPSRMN
IGQILETHLG WAASKGLGEN GGEPVFVSTP VFSGATVADI NEAIDKVRRN GAAEVGMSGG
GKVTLYDGRT GEPFENKITV GYMYILKLLH LVDDKIHARS TGPYSLVTQQ PLGGKAQFGG
QRFGEMEVWA LEAYGAAHTL QELLTIKSDD RVGRVKSYEA IVKGENIPSP SVPASFKVLL
KEMQSLGLSV KPIYDVEAVS EEDQERRDWD EAARALGINI SREEPPGQLD DTPDTFSRGG
M
