ID   RPOB_SALRD              Reviewed;        1287 AA.
AC   Q2S1Q5;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 2.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN   Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=SRU_1758;
OS   Salinibacter ruber (strain DSM 13855 / M31).
OC   Bacteria; Bacteroidetes; Bacteroidetes Order II. Incertae sedis;
OC   Rhodothermaceae; Salinibacter.
OX   NCBI_TaxID=309807;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 13855 / CECT 5946 / M31;
RX   PubMed=16330755; DOI=10.1073/pnas.0509073102;
RA   Mongodin E.F., Nelson K.E., Daugherty S., DeBoy R.T., Wister J., Khouri H.,
RA   Weidman J., Walsh D.A., Papke R.T., Sanchez Perez G., Sharma A.K.,
RA   Nesbo C.L., MacLeod D., Bapteste E., Doolittle W.F., Charlebois R.L.,
RA   Legault B., Rodriguez-Valera F.;
RT   "The genome of Salinibacter ruber: convergence and gene exchange among
RT   hyperhalophilic bacteria and archaea.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:18147-18152(2005).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC   -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC       and 1 omega subunit. When a sigma factor is associated with the core
CC       the holoenzyme is formed, which can initiate transcription.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABC45879.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000159; ABC45879.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_051010823.1; NC_007677.1.
DR   RefSeq; YP_445876.1; NC_007677.1.
DR   AlphaFoldDB; Q2S1Q5; -.
DR   SMR; Q2S1Q5; -.
DR   STRING; 309807.SRU_1758; -.
DR   PRIDE; Q2S1Q5; -.
DR   EnsemblBacteria; ABC45879; ABC45879; SRU_1758.
DR   KEGG; sru:SRU_1758; -.
DR   PATRIC; fig|309807.25.peg.1825; -.
DR   eggNOG; COG0085; Bacteria.
DR   HOGENOM; CLU_000524_4_1_10; -.
DR   Proteomes; UP000008674; Chromosome.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00653; RNA_pol_B_RPB2; 1.
DR   Gene3D; 2.30.150.10; -; 1.
DR   Gene3D; 2.40.270.10; -; 2.
DR   Gene3D; 2.40.50.150; -; 1.
DR   Gene3D; 3.90.1110.10; -; 1.
DR   HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR   InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR   InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR   InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR   InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR   InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR   InterPro; IPR010243; RNA_pol_bsu_bac.
DR   InterPro; IPR007121; RNA_pol_bsu_CS.
DR   InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR   InterPro; IPR007642; RNA_pol_Rpb2_2.
DR   InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR   InterPro; IPR007645; RNA_pol_Rpb2_3.
DR   InterPro; IPR007641; RNA_pol_Rpb2_7.
DR   InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR   PANTHER; PTHR20856; PTHR20856; 1.
DR   Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR   Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR   Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR   Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR   Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR   Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR   TIGRFAMs; TIGR02013; rpoB; 1.
DR   PROSITE; PS01166; RNA_POL_BETA; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transcription; Transferase.
FT   CHAIN           1..1287
FT                   /note="DNA-directed RNA polymerase subunit beta"
FT                   /id="PRO_0000237312"
SQ   SEQUENCE   1287 AA;  144621 MW;  B24658FB9F8D6DEC CRC64;
     MPTFLNGDIT TPGHLVDPDP RESFADIPEV WDYPDFLDVQ LKTFHDFVQD DVPPADREDV
     GLQAVFNEHF PIKDNRDRYT LEFVNYELDA PKHTVEECIA QGLTYSIPLK ATLRLTSKEE
     EGGEEAIEAI EQEVYLGTLP FMTDRGTFIV NGAERVIVSQ LHRSPGAFFE KEIHSNGTEL
     FSARVIPFRG SWMEFSTDVR DVLWAYVDRK KKVPVTTLLR ALGFSSDEEI VKMFDLADAV
     DIGDEDEFEE HLGRELATSV TIEKTIEIVD EDTGEVVDEE MEREVLLPAE HELEEGDWEE
     LDEYDVSRLY LVREDVEDEA LDKSTLVETL QKDSSHTEEE ALEVIYEKLR GSEAPDLDSA
     REALERLFFN EDRYDLGDVG RHRMNARLDV DVDTDEKVLT KEDVVGIVRE LIRLQNGEST
     ADDIDHLSNR RVKSVGEQLG SQFSLGLARM ARTIKERMNL RDADKFTPKD LVNARTIESV
     INTFFGTNQL SQFMDQTNAL AEMTHKRRMS ALGPGGLTRE RAGFEVRDVH HTHYGRLCPI
     ETPEGPNIGL MLSLCVHSTI NDFGFLETPY RVVEDGRVTD RVEYLSAEEE DQATVAQANA
     PIGDDGHFER DEVRCRHQGD FPIVEPEEVD YMDVAPNQIV SPSASLVPFL SHNDANRALM
     GSNMQRQGVP LLRSDSPIVG TGLEGRVAKD SRSCVVAEGE GVVEYVDAER LVVRYDEEQD
     KTDLTFGEPV QEYELTKFRR TNQGTCMNQK PIVQAGDRVE EGEVLTDGFA MEKGELALGK
     NVLCAFMPWH GYNYEDAIVI SERLVADDVY TSVHIEEFEH EVRDTKRGEE ELTREIPNVS
     EEATKDLDER GIVRVGAEIT PGDIIVGKIT PKGETDPTPE EKLLRAIFGD KAGDVKDASL
     KAKPGMEGGV VIDTRLFSRR ELDPASKKME EKRLENIESD HERKLADLNE RFWEKFFALV
     EDATSAGLED REGEVLLTEG ADFEEDAFDE VDPSDLSTRA EFTEDEELND QISTLLRNYK
     SRRRDIEGTT KRQKHQVEMG DELPSGVVQM AKVYVARKKK IEVGDKMAGR HGNKGVIAKI
     APVEDMPFLD DGTPVDLVLN PLGVPSRMNL GQIYETLLGW AGDRLGVKYA TPIFDGASLE
     DVGDELEKAG LPRDGKVQLY DGRTGEPFDE KTTVGQIYMM KLEHLVEDKM HARSIGPYSL
     ITQQPLGGKA QFGGQRLGEM EVWALYAYGA SNTLQEMLTF KSDDVEGRSE AYESIVKGEN
     LPSPGVPESF NVLVRELQGL GLEVTLD