ATRR_ASPOR
ID ATRR_ASPOR Reviewed; 894 AA.
AC Q2UEH7;
DT 11-DEC-2019, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=ABC-transporter-regulating transcription factor {ECO:0000303|PubMed:28052140};
GN Name=atrR {ECO:0000303|PubMed:28052140}; ORFNames=AO090026000614;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=28052140; DOI=10.1371/journal.ppat.1006096;
RA Hagiwara D., Miura D., Shimizu K., Paul S., Ohba A., Gonoi T., Watanabe A.,
RA Kamei K., Shintani T., Moye-Rowley W.S., Kawamoto S., Gomi K.;
RT "A novel Zn2-Cys6 transcription factor atrR plays a key role in an azole
RT resistance mechanism of Aspergillus fumigatus by co-regulating cyp51A and
RT cdr1B Expressions.";
RL PLoS Pathog. 13:E1006096-E1006096(2017).
CC -!- FUNCTION: Transcription factor that regulates expression of the genes
CC related to resistance to azole compounds.
CC {ECO:0000269|PubMed:28052140}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Results in a hypersensitivity to miconazole.
CC {ECO:0000269|PubMed:28052140}.
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DR EMBL; AP007159; BAE60038.1; -; Genomic_DNA.
DR RefSeq; XP_001822040.1; XM_001821988.1.
DR AlphaFoldDB; Q2UEH7; -.
DR SMR; Q2UEH7; -.
DR EnsemblFungi; BAE60038; BAE60038; AO090026000614.
DR GeneID; 5994068; -.
DR KEGG; aor:AO090026000614; -.
DR VEuPathDB; FungiDB:AO090026000614; -.
DR HOGENOM; CLU_011099_0_0_1; -.
DR OMA; CGETRYI; -.
DR PHI-base; PHI:6872; -.
DR Proteomes; UP000006564; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Membrane; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Transmembrane;
KW Transmembrane helix; Virulence; Zinc.
FT CHAIN 1..894
FT /note="ABC-transporter-regulating transcription factor"
FT /id="PRO_0000448725"
FT TRANSMEM 649..669
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DNA_BIND 71..98
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 159..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..747
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 894 AA; 99958 MW; 0560DF8F2B188B6D CRC64;
MDGMGEGPDG MGFDMPMLMN QQPHLFGGYS RDSSRGSPLN NVLSNPTYNE EPGMAGEDNN
DAKRRRIARA CDMCRKKKIK CDGKMPKCSH CINYRTDCVF TQVEKKRNPP KGAKYIEGLE
NRLGRMESLL RLSGLLSEDD GKTDLGTLEK RLADRSLGNT ALNSLKSPTN KFNGSSATSQ
SQHTTASRHS TPRMDSHSSP HTAATSPNSP KESETEVEGL SDMMCSLVTN NCGETRYIGS
SSGFSIFSPK GIQWVNEKTG DTSFQEMISS AYVDDNKWMY WKPEIFSDIF ARRVFKPLPP
KEEALSLFRD FFENFNCMFP LFHEPTFMHL VERQYSRDPY EGSGWWASIN VVLAIAHRLR
VMSNLVPQEE DKKAWLYLKN AMGVLTELTM RNTDLLSVQA LLGMSLFLQG TPNPQPSFFL
VAAAIRLSHS IGLHKRGSGF GLNPVEVEQR KRVFWIAYLL DKDICLRSGR PPVQDDDDMN
VELPSEDPPD NIGNVPLSDG KGKFNLFRTL CRFATIESKV YKRLYSAKAS KQSDGELLNT
IGELDRELEE WKDSIPIDFR PEHEIKASHT PLILHVVVLH FSYYNCLTTI HRMSVHHGYW
TSRLSNYAIQ GLNARPLNPR VFLSAVLCVT AARASINLIK YIPHGDFACV WLILYYPVSA
LVTLFANILQ NPNDARARSD VKLMNVVVNF LSTLVSDESN GSIKRMLGLC GEFERIAQVV
LDKAEKESHS KKKRKAAPDE PQDLRQKTPD ENSVPSPSTK RPTGAPPTAT LFPSSSYPIN
LGNTGPDMSN PTRAFAPGQT VLGTNGVPTS MQESMHTMSG MGHDFPEMLS PNNMDSVGFG
DQQPFGTPTE TPMTSFQQPF VPQDLWQMPM TIEWDWADMS SNFPVFEGTP NTGP
