ATRR_EMENI
ID ATRR_EMENI Reviewed; 854 AA.
AC Q5B4H2; A0A1U8QMT7; C8V869;
DT 11-DEC-2019, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=ABC-transporter-regulating transcription factor {ECO:0000303|PubMed:28052140};
GN Name=atrR {ECO:0000303|PubMed:28052140}; ORFNames=ANIA_04558;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=28052140; DOI=10.1371/journal.ppat.1006096;
RA Hagiwara D., Miura D., Shimizu K., Paul S., Ohba A., Gonoi T., Watanabe A.,
RA Kamei K., Shintani T., Moye-Rowley W.S., Kawamoto S., Gomi K.;
RT "A novel Zn2-Cys6 transcription factor atrR plays a key role in an azole
RT resistance mechanism of Aspergillus fumigatus by co-regulating cyp51A and
RT cdr1B Expressions.";
RL PLoS Pathog. 13:E1006096-E1006096(2017).
CC -!- FUNCTION: Transcription factor that regulates expression of the genes
CC related to resistance to azole compounds, including clotrimazole and
CC miconazole. {ECO:0000269|PubMed:28052140}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Results in a hypersensitivity to miconazole.
CC {ECO:0000269|PubMed:28052140}.
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DR EMBL; BN001303; CBF77260.1; -; Genomic_DNA.
DR EMBL; AACD01000078; EAA60901.1; -; Genomic_DNA.
DR RefSeq; XP_662162.1; XM_657070.1.
DR AlphaFoldDB; Q5B4H2; -.
DR SMR; Q5B4H2; -.
DR STRING; 162425.CADANIAP00005880; -.
DR EnsemblFungi; CBF77260; CBF77260; ANIA_04558.
DR EnsemblFungi; EAA60901; EAA60901; AN4558.2.
DR GeneID; 2872356; -.
DR KEGG; ani:AN4558.2; -.
DR eggNOG; ENOG502QZJZ; Eukaryota.
DR HOGENOM; CLU_011099_0_0_1; -.
DR InParanoid; Q5B4H2; -.
DR OMA; CGETRYI; -.
DR OrthoDB; 1013000at2759; -.
DR Proteomes; UP000000560; Chromosome III.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Membrane; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Transmembrane;
KW Transmembrane helix; Virulence; Zinc.
FT CHAIN 1..854
FT /note="ABC-transporter-regulating transcription factor"
FT /id="PRO_0000448726"
FT TRANSMEM 616..636
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DNA_BIND 71..98
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 158..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..708
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 854 AA; 95011 MW; 527CF85DA4FEB020 CRC64;
MDGIGEGHGP NGMGYDMPML MNQHTPIFGA YGPEGSPVTT ALPNPSLHDE ASMSIGDDNN
DAKRRRIARA CDMCRKKKIK CDGKMPKCSH CINYKTDCVF TQVEKKRNPP KGAKYIEGLE
NRLGRMESLL RLSGLLSEDD GKTDLGTLEK RLADRSLSAG GYNATNSPTR FSLPLNGQPS
QPASTSRHST PRVDSHSSPR TAATSPESQK ESENEVEGLS DMMCSLVTNN CGETRYIAYI
DDNKWMYWKP EIFSDVFARR VFKPLPPKEE ALSLFRDFFD NFNCMFPLFH EPTFMHLVEK
QYSRDPYEGS GWWASINVVL AISHRLRVMS NLVPQEEDKK AWLYLKNAMG VLTELTMRNT
DLLSVQALLG MSLFLQGTPN PQPSFFLVAA AIRLSHSIGL HKRGSGFGLN PVEAEQRKRV
FWIAYMLDKD ICLRSGRPPV QDDDDMNVEL PSEDPPDNIG NVPLFDGKGK FNMFRTLCKF
SIIESKVYKR LYSATASKQS DGALLNTIGE LDRELEEWKD SIPIDFRPEH EIKATHGPLI
LHIVVLHFAY YNCLTTIHRM SVHHGYWTSR LSNYAIQGLN ARPLNPRVFL SAVLCVTAAR
ASINLIKYIP QGDFACVWLI LYYPVSALVT LFANILQNPT DARARSDVKL MNVVVNFLST
LVSDESNGSI KRMLGVCGEF ERIAQVVLDK AERESQSKKK RKAGPEEPRD SPQAASTTST
KKNTANTSAT MPFSPPPQYG ADSQDSSSNA ANGATAFTSS QTMPGTSSIS DMSGTIPAMP
RASQDFTEML GPNALDGLNF NSQPPLTSTG DVPIAQPFQQ PFVPQDLWQM PMTIEWDWAD
MSTNFPVFDS GPSH
