ID   RPOB_STRS2              Reviewed;        1190 AA.
AC   A4VYU3;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN   Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=SSU98_0122;
OS   Streptococcus suis (strain 98HAH33).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=391296;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=98HAH33;
RX   PubMed=17375201; DOI=10.1371/journal.pone.0000315;
RA   Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X.,
RA   Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J.,
RA   Dong Y., Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F.,
RA   Yang R., Wang J., Yu J.;
RT   "A glimpse of streptococcal toxic shock syndrome from comparative genomics
RT   of S. suis 2 Chinese isolates.";
RL   PLoS ONE 2:E315-E315(2007).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC   -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC       and 1 omega subunit. When a sigma factor is associated with the core
CC       the holoenzyme is formed, which can initiate transcription.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000408; ABP91282.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4VYU3; -.
DR   SMR; A4VYU3; -.
DR   KEGG; ssv:SSU98_0122; -.
DR   HOGENOM; CLU_000524_4_1_9; -.
DR   OMA; FMTWEGY; -.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00653; RNA_pol_B_RPB2; 1.
DR   Gene3D; 2.40.270.10; -; 1.
DR   Gene3D; 2.40.50.150; -; 1.
DR   Gene3D; 3.90.1110.10; -; 1.
DR   HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR   InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR   InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR   InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR   InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR   InterPro; IPR010243; RNA_pol_bsu_bac.
DR   InterPro; IPR007121; RNA_pol_bsu_CS.
DR   InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR   InterPro; IPR007642; RNA_pol_Rpb2_2.
DR   InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR   InterPro; IPR007645; RNA_pol_Rpb2_3.
DR   InterPro; IPR007641; RNA_pol_Rpb2_7.
DR   InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR   PANTHER; PTHR20856; PTHR20856; 1.
DR   Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR   Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR   Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR   Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR   Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR   Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR   TIGRFAMs; TIGR02013; rpoB; 1.
DR   PROSITE; PS01166; RNA_POL_BETA; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription;
KW   Transferase.
FT   CHAIN           1..1190
FT                   /note="DNA-directed RNA polymerase subunit beta"
FT                   /id="PRO_0000300416"
SQ   SEQUENCE   1190 AA;  132870 MW;  C02E5BD057C016F6 CRC64;
     MAGHEVQYGK HRTRRSFSRI KEVLDLPNLI EIQTDSFQDF LDYGLKEVFE DVLPVSNFTD
     TMELEFVGYE LKEPKYTLEE ARAHDANYSA PIYVTFRLVN KETGEIKTQE VFFGEFPIMT
     EMGTFIINGA ERIIVSQLVR SPGVYFNDKV DKNGKVGYGS TVIPNRGAWL ELETDSKDIA
     YTRIDRTRKI PFTTLVRALG FSGDDEIFDI FGDSELVRNT IEKDIHKNPA DSRTDEALKE
     IYERLRPGEP KTAESSRSLL TARFFDPRRY DLAPVGRYKI NKKLNLRTRL LNQTLAEHVI
     NGETGEIVLE AGTVLSRDVL EKVEAQFDEL NLVEYIPNDN AVLLEPVLLQ KFKIVAPKDP
     ERVVTVIGNA NPAENVRTVT PADILAEMSY FLNLAEGLGR VDDIDHLGNR RIRAVGELLA
     NQVRIGLTRM ERNLRERMSV QDNEVLTPQQ IINIRPVTAA IKEFFGSSQL SQFMDQHNPL
     SELSHKRRLS ALGPGGLTRD RAGYEVRDVH YTHYGRMCPI ETPEGPNIGL INNLSSYGHL
     NKYGFIQTPY RKIDRATGTV TNEIVWLTAD EEDAYIVAQS TSPLDENNRF VDKIVMGRHQ
     GNNQEFPADS ADFMDVSPKQ VVAVATACIP FLENDDSNRA LMGANMQRQA VPLIDPKAPY
     VGTGMEYQAA HDSGAAIIAQ HDGKVVYADA DKVEVRREDG SLDVYHISKF RRSNSGTAYN
     QRTLVKLGDI VEKGDFIADG PSMENGEMAL GQNPIVAYMT WEGYNFEDAV IMSERLVKDD
     VYTSVHLEEY ESETRDTKLG PEEITREIPN VGEDALRNLD EMGIIRIGAE VKEGDILVGK
     VTPKGEKDLS AEERLLHAIF GDKSREVRDT SLRVPHGADG VVRDVKIFTR ANGDELQSGV
     NMLVRVYIAQ KRKIKVGDKM AGRHGNKGVV SRIVPVEDMP YLPDGTPVDI MLNPLGVPSR
     MNIGQVMELH LGMAARNLGI HIATPVFDGA SSEDLWSTVK EAGMDSDAKT ILYDGRTGEP
     FDNRVSVGVM YMIKLHHMVD DKLHARSVGP YSLVTQQPLG GKAQFGGQRF GEMEVWALEA
     YGASNVLQEI LTYKSDDVTG RLKAYEAITK GKPIPKPGVP ESFRVLVKEL QSLGLDMRVL
     DEDNNEVELR DLDEGEDDDI IHVDDLEKAR AKAAADAAAA FAAEEAEGKE