RPOB_SYNC1
ID RPOB_SYNC1 Reviewed; 1368 AA.
AC Q3A6Q4;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=Pcar_0694;
OS Syntrophotalea carbinolica (strain DSM 2380 / NBRC 103641 / GraBd1)
OS (Pelobacter carbinolicus).
OC Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC Syntrophotaleaceae; Syntrophotalea.
OX NCBI_TaxID=338963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 2380 / NBRC 103641 / GraBd1;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Chertkov O., Schmutz J., Larimer F.,
RA Land M., Kyrpides N., Ivanova N., Richardson P.;
RT "Complete sequence of Pelobacter carbinolicus DSM 2380.";
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; CP000142; ABA87953.1; -; Genomic_DNA.
DR RefSeq; WP_011340396.1; NC_007498.2.
DR AlphaFoldDB; Q3A6Q4; -.
DR SMR; Q3A6Q4; -.
DR STRING; 338963.Pcar_0694; -.
DR PRIDE; Q3A6Q4; -.
DR EnsemblBacteria; ABA87953; ABA87953; Pcar_0694.
DR KEGG; pca:Pcar_0694; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_0_7; -.
DR OMA; FMTWEGY; -.
DR OrthoDB; 9601at2; -.
DR Proteomes; UP000002534; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1368
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000224089"
SQ SEQUENCE 1368 AA; 152264 MW; E3E3F10F74660ED2 CRC64;
MAYSVANNQL LRKHFSTIKG IIEIPNLIDI QKNSYKRFLQ AGLPPSARKN IGLEAVFRSV
FPIRDFSETC SLDYVSYSLG TPKYDVGECH QRGMTFAAPV KVCVRLVSWD VDKESGVQAI
RDIKEQEVYF GEIPLMTENG TFIINGTERV IVSQLHRSPG VFFDHDKGKT HSSGKILYNA
RVIPYRGSWL DFDFDHKDLL YVRIDRRRKL PATVLLKALG YSAEELLNYY YQVETVTVDG
DSFKKKVNLD LLAGQRASTD VLGNDGEIIV KANRKFTKAA IRKLADSNVE YIPVSEEEIV
GKVASTDIVD VSTGEVIVEC NEEISESKLE ELRTRGIVEF NILFIDHLHV GPYLRETLLL
DRMATPEDAR IEIYRRLRPG DPPTIKSANA LFESLFFNPE RYDLSVVGRI KLNYKLGLQS
PEDQTTLTKD DILEVVRYLI GLRDGRGTID DIDHLGNRRV RAVGELLENQ YRVGLVRMER
AIKERMSLQE VDSLMPHDLI NSKPVSAVVK EFFGSSQLSQ FMDQTNPLSE ITHKRRLSAL
GPGGLTRERA GFEVRDVHPT HYGRVCPIET PEGPNIGLIA SLSTYARINE HGFVETPYRI
VEQGKVTNEI RYFSALEEGG HAIAQANAPL DDDGRFLNEL VNARQNGEFV LIQREEIGLM
DVSPKQLVSV AASLIPFLEN DDANRALMGS NMQRQAVPLL RADAPLVGTG MERIVAHDSG
AAVVARHNGV VESVDASRIV VKIDEGEVDE DGTGVDIYNL IKFARSNQNT CLNQKPIVKV
GDRVASGGII ADGPSTEWGE LALGQNVLVA FMPWEGYNFE DSILISEKLV KEDRYTSIHI
EELECVARDT KLGKEEITND IPNLGEDALK DLDESGIVRI GAEVKPGDIL VGKITPKGET
QLSPEEKLLR AIFGEKAGDV RDTSLRLPPG VEGVVIGARV FSRKGSDKDS RTEYIEKTEI
EKLLKDQHDE IRIIRESTHG KLESLLVGQT SASALFDAAG KELLGQGEKI TSEVLAEVPF
ARWREISLLD ASENEEKLSA IMTSLAQREE LIKAVFADKI EKIKRGDDLP PGVIKMVKVY
IAIKRKLSVG DKMAGRHGNK GVLSRVLPEE DMPYMADGTP VEIVLNPLGV PSRMNVGQIL
ETHLGLAARG LGVQIQEHLD RYYTPEAMRT KIGECYEDDR VAEFVDALPD DEVMQLARQL
SRGVPMASPV FEGVTEEQMK NQMERAGFAS SGQMTLYNGK TGEAFKEKVT VGIMYMLKLH
HLVDDKIHAR SIGPYSLVTQ QPLGGKAQFG GQRLGEMEVW AMEAYGAAHA LQEFLTVKSD
DVTGRTRMYE AIVKGKHTLE AGLPESFNVL IKELQSLCLD VELLEEQE
