RPOB_SYNY3
ID RPOB_SYNY3 Reviewed; 1102 AA.
AC P77965;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=sll1787;
OS Synechocystis sp. (strain PCC 6803 / Kazusa).
OC Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC unclassified Synechocystis.
OX NCBI_TaxID=1111708;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 6803 / Kazusa;
RX PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT genome and assignment of potential protein-coding regions.";
RL DNA Res. 3:109-136(1996).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: In cyanobacteria the RNAP catalytic core is composed of 2
CC alpha, 1 beta, 1 beta', 1 gamma and 1 omega subunit. When a sigma
CC factor is associated with the core the holoenzyme is formed, which can
CC initiate transcription. {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; BA000022; BAA17365.1; -; Genomic_DNA.
DR PIR; S77518; S77518.
DR AlphaFoldDB; P77965; -.
DR SMR; P77965; -.
DR DIP; DIP-37767N; -.
DR IntAct; P77965; 10.
DR STRING; 1148.1652443; -.
DR PaxDb; P77965; -.
DR EnsemblBacteria; BAA17365; BAA17365; BAA17365.
DR KEGG; syn:sll1787; -.
DR eggNOG; COG0085; Bacteria.
DR InParanoid; P77965; -.
DR OMA; FMTWEGY; -.
DR PhylomeDB; P77965; -.
DR Proteomes; UP000001425; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..1102
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000047982"
FT REGION 1076..1102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1102 AA; 123365 MW; 40235F5EBA7CE881 CRC64;
MTNLATTMLP DLIEIQHASF HWFLEEGLIE ELNSFSPISD YTGKLELHFL GKDYKLKQPK
YDVDESKRRD ASYSVQMYVP TRLINKETGE IKEQEVFIGD LPLMTERGTF IINGAERVIV
NQIVRSPGVY YKKELDKNGR RTYSASLIPN RGAWLKFETD KNGLVYVRID KTRKLSAQVL
LKAIGLSDNE ILDSLSHPEF YQKTLDKEGN PTEEEALVEL YKKLRPGEPP TVSGGQQLLE
SRFFDPKRYD LGRVGRYKLN KKLRLNEADT TRVLTPQDIL AAINYLINLE FDVGTTDDID
HLGNRRVRSV GELLQNQIRV GLNRLERIIR ERMTVSESDA LTPASLVNPK PLVAAIKEFF
GSSQLSQFMD QTNPLAELTH KRRISALGPG GLTRERAGFA VRDIHPSHHG RICPVETPEG
PNAGLIGSLA TCARVNDYGF IETPYFRVES GRVRKDLDPV YLTADEEDDM RVAPGDIPTD
EEGNIIGESV PIRYRQEFST TSPEQVDYVA VSPVQIISVA TSMIPFLEHD DANRALMGSN
MQRQAVPLLR PERPLVGTGL EAQAARDSGM VIVSRTHGIV TYVDATEIRV QPHSPDNPAE
KGEEIVYPIQ KYQRSNQDTC LNQRPLVYAG EDVVPGQVLA DGSATEGGEL ALGQNILVAY
MPWEGYNYED AILISERLVY DDVYTSIHIE KFEIEARQTK LGPEEITREI PNVGEDALRN
LDEHGIIRIG AWVESGDILV GKVTPKGEAD QPPEEKLLRA IFGEKARDVR DNSLRVPNGE
KGRVVDVRVF TREKGDELPP GANMVVRIYV AQKRKIQVGD KMAGRHGNKG IISRILPIED
MPYLPDGRPI DIALNPLGVP SRMNVGQVFE CLLGWAGENL GVRFKITPFD EMYGEEASRD
TVHGLLEEAS QRPNKDWVFN ENHPGKIQVF DGRTGEPFDR PITVGQAYML KLVHLVDDKI
HARSTGPYSL VTQQPLGGKA QQGGQRFGEM EVWALEAYGA AYILQELLTV KSDDMQGRNE
ALNAIVKGKS IPRPGTPESF KVLMRELQSL GLDIAAHKVQ LSEDGESADA EVDLMIDSQR
RAPNRPTYES LHTEEDLEEE EV
