ID   RPOB_THEPA              Reviewed;        1005 AA.
AC   Q4MY95;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta;
DE            EC=2.7.7.6;
DE   AltName: Full=PEP;
DE   AltName: Full=Plastid-encoded RNA polymerase subunit beta;
DE            Short=RNA polymerase subunit beta;
GN   Name=rpoB; OrderedLocusNames=TP05_0028;
OS   Theileria parva (East coast fever infection agent).
OG   Plastid; Apicoplast.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Theileriidae; Theileria.
OX   NCBI_TaxID=5875;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Muguga;
RX   PubMed=15994558; DOI=10.1126/science.1110439;
RA   Gardner M.J., Bishop R., Shah T., de Villiers E.P., Carlton J.M., Hall N.,
RA   Ren Q., Paulsen I.T., Pain A., Berriman M., Wilson R.J.M., Sato S.,
RA   Ralph S.A., Mann D.J., Xiong Z., Shallom S.J., Weidman J., Jiang L.,
RA   Lynn J., Weaver B., Shoaibi A., Domingo A.R., Wasawo D., Crabtree J.,
RA   Wortman J.R., Haas B., Angiuoli S.V., Creasy T.H., Lu C., Suh B.,
RA   Silva J.C., Utterback T.R., Feldblyum T.V., Pertea M., Allen J.,
RA   Nierman W.C., Taracha E.L.N., Salzberg S.L., White O.R., Fitzhugh H.A.,
RA   Morzaria S., Venter J.C., Fraser C.M., Nene V.;
RT   "Genome sequence of Theileria parva, a bovine pathogen that transforms
RT   lymphocytes.";
RL   Science 309:134-137(2005).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6;
CC   -!- SUBUNIT: In plastids the minimal PEP RNA polymerase catalytic core is
CC       composed of four subunits: alpha, beta, beta', and beta''. When a
CC       (nuclear-encoded) sigma factor is associated with the core the
CC       holoenzyme is formed, which can initiate transcription (Potential).
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Plastid, apicoplast.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000305}.
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DR   EMBL; AAGK01000009; EAN30414.1; -; Genomic_DNA.
DR   RefSeq; XP_762697.1; XM_757604.1.
DR   AlphaFoldDB; Q4MY95; -.
DR   SMR; Q4MY95; -.
DR   STRING; 5875.XP_762697.1; -.
DR   EnsemblProtists; EAN30414; EAN30414; TP05_0028.
DR   GeneID; 3882257; -.
DR   KEGG; tpv:TP05_0028; -.
DR   VEuPathDB; PiroplasmaDB:TpMuguga_05g00028; -.
DR   eggNOG; KOG0214; Eukaryota.
DR   InParanoid; Q4MY95; -.
DR   OMA; FMTWEGY; -.
DR   Proteomes; UP000001949; Unassembled WGS sequence.
DR   GO; GO:0020011; C:apicoplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.40.270.10; -; 1.
DR   InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR   InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR   InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR   InterPro; IPR007121; RNA_pol_bsu_CS.
DR   InterPro; IPR007645; RNA_pol_Rpb2_3.
DR   PANTHER; PTHR20856; PTHR20856; 1.
DR   Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR   Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR   PROSITE; PS01166; RNA_POL_BETA; 1.
PE   3: Inferred from homology;
KW   Apicoplast; DNA-directed RNA polymerase; Nucleotidyltransferase; Plastid;
KW   Reference proteome; Transcription; Transferase.
FT   CHAIN           1..1005
FT                   /note="DNA-directed RNA polymerase subunit beta"
FT                   /id="PRO_0000232685"
SQ   SEQUENCE   1005 AA;  118813 MW;  F13D29FC50E8D845 CRC64;
     MNCTVGNNIY HTYINYFVNN IYNSLSRNIN SKINKYYNYY KKSKIFKNIK FYFNLLTFES
     NYCCDSGQNK YLYDGYNSYY FINIPLQIKF NNLKSRFINY NIINIPKINQ SGDIILNGYL
     RLPILYLQLA TNNISYIFNE KITRTYFIKI KNNIYLYIYL YDDFITVYIN SYKIKNDLFS
     MYNNVSFKNK YINFSKIDNV IYVMNLKNNN IKYHIFDKTI NINNFVNNTM FMDILSIVNK
     FLNLNLKKKF IQSSNNLINK STNSVLKTIF RQFTKSVTIF DIEKYCDKLL YKKKIFRSFN
     IVLFKEHLLV NPVIHYTDQL NVLSYLTNKF KINIFGYSNS SNDKFKVSTN LRKIQSDYIG
     FINIVNTPDG DTCGLISKLA NNTILDKFKL KLINCNNEYF ENFTKIDITS KNLYNMTSNN
     FINIKKNSTF KVKQIEVFKN NEFKLINFDK NKTNKNLNVF NTLSITELII PFLFNNDPCR
     GLMGSKMHTQ ALPLIYNEHP YVMTKYNHMN GLLFNKCITS LCEGIIVSVN NYKIIVMDDK
     NRYLHYYLYP FNVLDYNSFV SYKPIVWVGE KINIGKILAL PSDLKHSEFT LGVNNLLNYS
     FYNGYEHEDA IVINKNLIIE DILTSISFDV YEEYLSINKL DYVELTLRHL LEYNRYNRYL
     INEVGVSSNQ DYMLFGDILS TKIRYELSLS KNKKFFKVFK LIFKENKKLI VYTKPLTIKR
     GGEGRLIKYE ILGYSKFRQL DAMYPEINVS YLTLRFFIFK IDRINIGDKL CGRHGNKGVV
     SKIVDNIDLP YTFRGLCPYS ITSPIGALAR INLGQFLEGS CGYFGLNFNC RIKAPINLYN
     YHLYSNMYLK NIFNSLNVYN NSYINFSIEK YLRDFKTGYQ LKNFNLMLMP YFLKLMHTSK
     SKFQYRTVGK YSSLTQQPVK GKRVNGSQKF GEMEVWALES HGSAYTIREL GYIKTNVKYF
     KKFEHKGYKG SETFKVLTLE LKNVLININR VDNYSYFNQK IKYNY