ID   RPOB_TREDE              Reviewed;        1167 AA.
AC   Q73JJ7;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN   Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=TDE_2421;
OS   Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153
OS   / KCTC 15104).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243275;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104;
RX   PubMed=15064399; DOI=10.1073/pnas.0307639101;
RA   Seshadri R., Myers G.S.A., Tettelin H., Eisen J.A., Heidelberg J.F.,
RA   Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J.,
RA   Ren Q., Brinkac L.M., Madupu R., Kolonay J.F., Durkin S.A., Daugherty S.C.,
RA   Shetty J., Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G.,
RA   Malek J.A., Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K.,
RA   Pal S., Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E.,
RA   Baca E., Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T.;
RT   "Comparison of the genome of the oral pathogen Treponema denticola with
RT   other spirochete genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC   -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC       and 1 omega subunit. When a sigma factor is associated with the core
CC       the holoenzyme is formed, which can initiate transcription.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR   EMBL; AE017226; AAS12939.1; -; Genomic_DNA.
DR   RefSeq; NP_973020.1; NC_002967.9.
DR   RefSeq; WP_002680361.1; NC_002967.9.
DR   AlphaFoldDB; Q73JJ7; -.
DR   SMR; Q73JJ7; -.
DR   STRING; 243275.TDE_2421; -.
DR   EnsemblBacteria; AAS12939; AAS12939; TDE_2421.
DR   GeneID; 2739846; -.
DR   KEGG; tde:TDE_2421; -.
DR   PATRIC; fig|243275.7.peg.2288; -.
DR   eggNOG; COG0085; Bacteria.
DR   HOGENOM; CLU_000524_4_3_12; -.
DR   OMA; FMTWEGY; -.
DR   OrthoDB; 9601at2; -.
DR   Proteomes; UP000008212; Chromosome.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00653; RNA_pol_B_RPB2; 1.
DR   Gene3D; 2.30.150.10; -; 1.
DR   Gene3D; 2.40.270.10; -; 2.
DR   Gene3D; 2.40.50.150; -; 1.
DR   Gene3D; 3.90.1110.10; -; 2.
DR   HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR   InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR   InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR   InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR   InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR   InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR   InterPro; IPR010243; RNA_pol_bsu_bac.
DR   InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR   InterPro; IPR007642; RNA_pol_Rpb2_2.
DR   InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR   InterPro; IPR007645; RNA_pol_Rpb2_3.
DR   InterPro; IPR007641; RNA_pol_Rpb2_7.
DR   InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR   PANTHER; PTHR20856; PTHR20856; 1.
DR   Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR   Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR   Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR   Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR   Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR   Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR   TIGRFAMs; TIGR02013; rpoB; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transcription; Transferase.
FT   CHAIN           1..1167
FT                   /note="DNA-directed RNA polymerase subunit beta"
FT                   /id="PRO_0000224118"
SQ   SEQUENCE   1167 AA;  131849 MW;  0C72F1182AB2F1D4 CRC64;
     MFARGQKIDR RYYGKDVPNF MELPNLIDIQ IQSYNKFLNK EKKTDETEIE GLESVFHTTF
     PIESTNEDMA LQYLSYSLDY DSIKFSEIEC KQKGLTYSVP LKAEIDLFFK ETKEIRRKNI
     YMGDIPLMTE RGTFIINGAE RVVVSQIHRS PGVIFSHEKG VYSSRIIPYR GTWLEFEIDQ
     KKELIYAKLD SKKRILGTIF LRALGYDTRE KIIDLFYKTK TAKISPDRTE YEELIGQVLA
     RDVYVKGEDG EKRKMHQAGE KIHPHNIDDL IQNDVKKITI IDFKGKDSLD SQIIINCFER
     EEIKYTPDPA VNDEPTVEDA LNAVYSVIRP GDPITYENAK EDLHNMFFTA RRYDIGKVGR
     YKLNKKFDYS DDVKGTTLIE EDIFKTMKFL IKVYIGEESI DDIDHLGNRR IRSVGEIMTD
     VLKKAFSRME RIARDRMSSK EMDTIKPKDL ISIKPIVAAI KEFFGASQLS QFMDQVNPLA
     ELTHKRRLNA LGPGGLSRDR AGFEVREVHY THYGRMCPIE TPEGPNIGLI VSMANYARVN
     EYGFLEAPYV KVVNGVATRE IEYLSAMDED KYFIGQVSSA IGKDGKINTD QVSCRKLGDY
     TSISPKDIQY MDVSPKQIIS VSASLIPFLE HDDANRALMG SNMQRQAVPL VFPEPPRVGT
     GMEKKCAYDS GVLVKAKRSG KVEFVSSDTI IIAPEKGKNK EDKDEYTLLK YQRTNQETCY
     HQRPIVNVGD TVKAGQPIAD GPATYNGELA LGRNILVGFV PWNGYNYEDA ILISRRVVKE
     DMFTSIHIKE LSTDVRETKL GAEKMTCDIP NKSEKSLDDL DSEGIIRIGS KVKPGDILVG
     KVTPKSESDT TPEFKLLNSI FGEKAKEVRD TSLRVPHGTE GTVIDVQRLK RDQGDDLSPG
     VDEVVKVLIA TKRKLREGDK MAGRHGNKGL VARILPEEDM PYMEDGTPLD ICLNPLGVPS
     RMNIGQILES ELGLAGLKLN EWYESPVFES PSMEQIEAKL KEAGYPTSSK VKLRDGLTGR
     LFENEVFVGV IYFLKLAHLV DDKMHARSTG PYSLVTQQPL GGKAQFGGQR LGEMEVWALE
     AYGAANTLQE LITIKSDDMH GRSKIYESIV KGEPSSSAGI PESFNVLVQE LRGLALDFTI
     YDAKGQQIPL TERDEELIKR EKTSTNF