RPOB_VESOH
ID RPOB_VESOH Reviewed; 1360 AA.
AC A5CW25;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321}; OrderedLocusNames=COSY_0736;
OS Vesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA).
OC Bacteria; Proteobacteria; Gammaproteobacteria; sulfur-oxidizing symbionts;
OC Candidatus Vesicomyosocius.
OX NCBI_TaxID=412965;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HA;
RX PubMed=17493812; DOI=10.1016/j.cub.2007.04.039;
RA Kuwahara H., Yoshida T., Takaki Y., Shimamura S., Nishi S., Harada M.,
RA Matsuyama K., Takishita K., Kawato M., Uematsu K., Fujiwara Y., Sato T.,
RA Kato C., Kitagawa M., Kato I., Maruyama T.;
RT "Reduced genome of the thioautotrophic intracellular symbiont in a deep-sea
RT clam, Calyptogena okutanii.";
RL Curr. Biol. 17:881-886(2007).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR EMBL; AP009247; BAF61848.1; -; Genomic_DNA.
DR RefSeq; WP_011930118.1; NC_009465.1.
DR AlphaFoldDB; A5CW25; -.
DR SMR; A5CW25; -.
DR STRING; 412965.COSY_0736; -.
DR PRIDE; A5CW25; -.
DR EnsemblBacteria; BAF61848; BAF61848; COSY_0736.
DR KEGG; vok:COSY_0736; -.
DR eggNOG; COG0085; Bacteria.
DR HOGENOM; CLU_000524_4_3_6; -.
DR OMA; FMTWEGY; -.
DR OrthoDB; 9601at2; -.
DR Proteomes; UP000000247; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00653; RNA_pol_B_RPB2; 1.
DR Gene3D; 2.30.150.10; -; 1.
DR Gene3D; 2.40.270.10; -; 1.
DR Gene3D; 2.40.50.150; -; 1.
DR Gene3D; 3.90.1110.10; -; 1.
DR HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR InterPro; IPR010243; RNA_pol_bsu_bac.
DR InterPro; IPR007121; RNA_pol_bsu_CS.
DR InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR InterPro; IPR007642; RNA_pol_Rpb2_2.
DR InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR InterPro; IPR007645; RNA_pol_Rpb2_3.
DR InterPro; IPR007641; RNA_pol_Rpb2_7.
DR InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR PANTHER; PTHR20856; PTHR20856; 1.
DR Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR TIGRFAMs; TIGR02013; rpoB; 1.
DR PROSITE; PS01166; RNA_POL_BETA; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription;
KW Transferase.
FT CHAIN 1..1360
FT /note="DNA-directed RNA polymerase subunit beta"
FT /id="PRO_0000300424"
SQ SEQUENCE 1360 AA; 152158 MW; A0019E9B0001C240 CRC64;
MAYSFTEKKR IRNNFGSRES ILTEPDLLAI QIDSFNSFIQ ADNKIKQDIG LHNVLQSVFP
ITAVNGYAQI EYVDYQLKEP KFNVEECKLR GVTFASTLRV KLNLVLFDKN GSTLKKKRKV
KQIIEEDVYL GQLPLMTETG TFVINGTERV VVSQLHRSPG VIFEHDKGKT HSSGKILFSS
RIIPYRGSWL DFEYDHHEHL YVRIDRRRKL PVTTLLRAMG LSSEDILETF FEKTPVKLKA
KSCDLSMLPI HLQRTIAEFD IVVNQHVVVE KGRRITAKHV KLLGKAGIKS INAPLEYLLD
KVICADIINK DTGEILISAN TITSEEVLEL LNTNKVKKIE ILYINSSETG AYISDTLRLD
ETQTEIEARM SIYHVMRPGE PATEDAVNLL FNNLFFKNDR YDLSKVGRMK LNRRLGISRE
TGEHVLTNDD IIRVIKLLIN IKDGNDSVDD IDTLANRRVR AIGEMIENQF RIGLVRVEKA
VREGLNLAET DELTPQDLIN SKPVSAAVRE FFGSSQLSQF MDQVNPLSGV THKRRISALG
PGGLTRERAG FEVRDVHPSH YGRLCPIETP EGPNIGLINT LAVYAKTNSY GFLETPYQIV
KNGKVTKEVI YVSAIDEITH TIAQANALVD DRGKLMDDLI SCRHKNEFVL VDSSEVTLID
IDSKQISSVA ASLIPFLEHD DANRALMGSN MQRQAVPVLK AEKPLVGTGI ERVVAKDSRV
CVTAKHGGVV EAVDASRIVI RVDSKKTKAN ELGVDIYNLT KYSRSNQNTC INQKPLVRTG
DKITFGDVLA DGPSTDMGEL ALGQNMKIAF MPWNGYNFED SILISEKVVQ EDRYTTIHIE
ELTAYSRDTK LGPEEITSDI PNVSESALSK LDEVGVVYVG ARVKGGDILV GKVTPKSETV
LSPEEKLLRA IFGEKANNVK DSSLRIGASK SGVVIDVQVF TRDRVEKDIR ALSIDAERLE
RIKKDIDDEF SIIDGDIFRR IRLKLLGNVL SKAIGDIRIG ERLSIKLMKK FDNKDIAKFK
VENATVNKEV AVLVKQAKAK KVEFEKFFKK EKAKINEGAE LPPGVMKMVK VYVATRKTLQ
VGDKMAGRHG NKGVISRVSP VEDMPYLADG STIDIVLNPL GVPSRMNVGQ VLEVHLGYAA
KGLGYKIAAI LDERRPDMVK QIRVFLDKVY NLHGKKEDLT LFSNEEIIEL ANNLREGVPM
ATPVFDGIRE QDIKSLLRLA DLPESGQEQL YDGRTGEPFD RHVTVGYMHM LKLNHLVDDK
MHARSTGPYS LVTQQPLSGK AQFGGQRFGE MEVWALEAYG AAHTLREMLT VKSDDVAGRA
KMYKSIVDGK NLTESVMPES FNVLVKEIRS LGIDVELEQH
