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AB3F_ARATH
ID   AB3F_ARATH              Reviewed;         715 AA.
AC   Q8H0V6; Q9SGW1;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=ABC transporter F family member 3;
DE            Short=ABC transporter ABCF.3;
DE            Short=AtABCF3;
DE   AltName: Full=GCN20-type ATP-binding cassette protein GCN3;
GN   Name=ABCF3; Synonyms=GCN3; OrderedLocusNames=At1g64550; ORFNames=F1N19.11;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA   Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT   "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL   J. Biol. Chem. 276:30231-30244(2001).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA   Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA   Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA   Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT   "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL   Trends Plant Sci. 13:151-159(2008).
RN   [6]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, CLEAVAGE OF INITIATOR
RP   METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP   [LARGE SCALE ANALYSIS].
RX   PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA   Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA   Giglione C.;
RT   "Comparative large-scale characterisation of plant vs. mammal proteins
RT   reveals similar and idiosyncratic N-alpha acetylation features.";
RL   Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCF family.
CC       EF3 (TC 3.A.1.121) subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF19673.1; Type=Erroneous gene model prediction; Note=The predicted gene At1g64540 has been split into 2 genes: At1g64540 and At1g64550.; Evidence={ECO:0000305};
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DR   EMBL; AC009519; AAF19673.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE34252.1; -; Genomic_DNA.
DR   EMBL; BT002015; AAN72026.1; -; mRNA.
DR   EMBL; BT010544; AAQ65167.1; -; mRNA.
DR   PIR; A96669; A96669.
DR   RefSeq; NP_176636.1; NM_105130.4.
DR   AlphaFoldDB; Q8H0V6; -.
DR   SMR; Q8H0V6; -.
DR   BioGRID; 27984; 1.
DR   STRING; 3702.AT1G64550.1; -.
DR   iPTMnet; Q8H0V6; -.
DR   PaxDb; Q8H0V6; -.
DR   PRIDE; Q8H0V6; -.
DR   ProteomicsDB; 244398; -.
DR   EnsemblPlants; AT1G64550.1; AT1G64550.1; AT1G64550.
DR   GeneID; 842763; -.
DR   Gramene; AT1G64550.1; AT1G64550.1; AT1G64550.
DR   KEGG; ath:AT1G64550; -.
DR   Araport; AT1G64550; -.
DR   TAIR; locus:2019409; AT1G64550.
DR   eggNOG; KOG0062; Eukaryota.
DR   HOGENOM; CLU_000604_36_6_1; -.
DR   InParanoid; Q8H0V6; -.
DR   OMA; CTHIADI; -.
DR   OrthoDB; 580544at2759; -.
DR   PhylomeDB; Q8H0V6; -.
DR   PRO; PR:Q8H0V6; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q8H0V6; baseline and differential.
DR   Genevisible; Q8H0V6; AT.
DR   GO; GO:0005634; C:nucleus; HDA:TAIR.
DR   GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IMP:TAIR.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR032781; ABC_tran_Xtn.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 2.
DR   Pfam; PF12848; ABC_tran_Xtn; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   1: Evidence at protein level;
KW   Acetylation; ATP-binding; Nucleotide-binding; Reference proteome; Repeat;
KW   Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0007744|PubMed:22223895"
FT   CHAIN           2..715
FT                   /note="ABC transporter F family member 3"
FT                   /id="PRO_0000274941"
FT   DOMAIN          175..436
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          504..713
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   REGION          96..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..118
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         207..214
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         537..544
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   MOD_RES         2
FT                   /note="N-acetylthreonine"
FT                   /evidence="ECO:0007744|PubMed:22223895"
SQ   SEQUENCE   715 AA;  79644 MW;  6CA38DEDFCD1D392 CRC64;
     MTEVASSVVY EVLGRRAQDV DEPIMDYIIN VLADEDFDFG EEGEGAFDAV GELLVAAECV
     SDFEECRLVC SKLSDKFGKH GLVKPTPTVR SLAMPVRMND GMDDGPVKKK KPEPVDGPLL
     TERDLAKIER RKKKDDRQRE LQYQQHVAEM EAAKAGMPTV SVNHDTGGGS AIRDIHMDNF
     NVSVGGRDLI VDGSITLSFG RHYGLVGRNG TGKTTFLRYM AMHAIEGIPT NCQILHVEQE
     VVGDKTTALQ CVLNTDIERT KLLEEEIQIL AKQRETEEPT AKDGMPTKDT VEGDLMSQRL
     EEIYKRLDAI DAYTAEARAA SILAGLSFTP EMQLKATNTF SGGWRMRIAL ARALFIEPDL
     LLLDEPTNHL DLHAVLWLET YLTKWPKTFI VVSHAREFLN TVVTDIIHLQ NQKLSTYKGN
     YDIFERTREE QVKNQQKAFE SSERSRSHMQ AFIDKFRYNA KRASLVQSRI KALDRLAHVD
     QVINDPDYKF EFPTPDDKPG PPIISFSDAS FGYPGGPLLF RNLNFGIDLD SRIAMVGPNG
     IGKSTILKLI SGDLQPSSGT VFRSAKVRVA VFSQHHVDGL DLSSNPLLYM MRCYPGVPEQ
     KLRSHLGSLG VTGNLALQPM YTLSGGQKSR VAFAKITFKK PHLLLLDEPS NHLDLDAVEA
     LIQGLVLFQG GICMVSHDEH LISGSVDELW VVSDGRIAPF HGTFHDYKKL LQSST
 
 
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