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ATR_ORYSJ
ID   ATR_ORYSJ               Reviewed;        2710 AA.
AC   Q5Z987;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Serine/threonine-protein kinase ATR;
DE            EC=2.7.11.1;
GN   OrderedLocusNames=Os06g0724700, LOC_Os06g50910;
GN   ORFNames=P0535F09.39, P0548E04.6;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: Probable serine/threonine kinase. Seems to play a central
CC       role in cell-cycle regulation by transmitting DNA damage signals to
CC       downstream effectors of cell-cycle progression. May recognize the
CC       substrate consensus sequence [ST]-Q and phosphorylate histone variant
CC       H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA
CC       damage response mechanism (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AP003685; BAD61693.1; -; Genomic_DNA.
DR   EMBL; AP007231; BAD62537.1; -; Genomic_DNA.
DR   EMBL; AP014962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK109634; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_015643715.1; XM_015788229.1.
DR   SMR; Q5Z987; -.
DR   STRING; 4530.OS06T0724700-01; -.
DR   PaxDb; Q5Z987; -.
DR   PRIDE; Q5Z987; -.
DR   GeneID; 4342103; -.
DR   KEGG; osa:4342103; -.
DR   eggNOG; KOG0890; Eukaryota.
DR   InParanoid; Q5Z987; -.
DR   OrthoDB; 80538at2759; -.
DR   Proteomes; UP000000763; Chromosome 6.
DR   Proteomes; UP000059680; Chromosome 6.
DR   Genevisible; Q5Z987; OS.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0000077; P:DNA damage checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR   GO; GO:0000723; P:telomere maintenance; IBA:GO_Central.
DR   Gene3D; 1.10.1070.11; -; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003152; FATC_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR003151; PIK-rel_kinase_FAT.
DR   InterPro; IPR014009; PIK_FAT.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR012993; UME.
DR   Pfam; PF02259; FAT; 1.
DR   Pfam; PF02260; FATC; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF08064; UME; 1.
DR   SMART; SM01343; FATC; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SMART; SM00802; UME; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51189; FAT; 1.
DR   PROSITE; PS51190; FATC; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cell cycle; DNA damage; DNA repair; Kinase;
KW   Nucleotide-binding; Nucleus; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase.
FT   CHAIN           1..2710
FT                   /note="Serine/threonine-protein kinase ATR"
FT                   /id="PRO_0000225631"
FT   DOMAIN          1647..2257
FT                   /note="FAT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00534"
FT   DOMAIN          2368..2680
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT   DOMAIN          2678..2710
FT                   /note="FATC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00534,
FT                   ECO:0000255|PROSITE-ProRule:PRU00535"
FT   REGION          2374..2380
FT                   /note="G-loop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT   REGION          2545..2553
FT                   /note="Catalytic loop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT   REGION          2565..2589
FT                   /note="Activation loop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
SQ   SEQUENCE   2710 AA;  303424 MW;  03B3F8AD0555CC1E CRC64;
     MANFSSHIQE LRELIAASST TTSTSAPASV HFEVKLREVL PNLLRDYVVP SSPTADGREA
     TAVLKLLSYT AGKFPGVFFH GRAADVIRVI GRVLPFFAEP NFRSRHEIIF DTVWSLLSLL
     RTGDREAYRQ FFLDVMVAVQ DVLYVVASMH GDRPSGVLTE RYLVKCLCGS FSDILDSPGI
     FSDLPDSCQP KNGPGVLVDL TGETRWRPFA TMLIKLVNKC LADGTLYVEG LVNMPFVSAA
     CSIICYGDES LHKVCFDFAR IVATVITVEI LPVENIIRSI MCILSQDVNG LSDIRDADYD
     FSMGACLHAL HSSCPGYIVA ITASDIVNVF QRAVHTSRSS ELQVAMCNAY KRIVELCSPR
     VWKPEILLKL LCLPKPCAKL IECIRLVVDK SGQSFLSSDD RDDGSSLLAK SEGLDLPKVG
     QKRIALDEEN SFPKRLKMTE PRFSSGSFMV DELSAGVGQE LEKDHGCDFR VQLYSLINCL
     SPDNHMAYPL EPAISIQVLS LLCLSLSVYP KTNLFSRISK QVLSWIPWIC KQTTKICMFS
     FDVSLYFEAV QTVMLLQSFL PGHTKLFEDE PLLIGNGCTD FEYPRYADLI NLLKLVSDDG
     YLTSQTCSEK LKCLAVQIIA KIGSRQNAEC DLQVLELAIQ SETGELQNEA LMSLPIIVLY
     SGPRMLGAMF RKLETIGTLG CKKLWKSIAI SLGFLSCLNG TTDCTDKVGN HCKLFLAKHC
     EQPILTLNLL RGFWCPQCDV RTVHIEDQVP IVDIALSEDK NIDFKINMFK AHSLFFKFLY
     AETSEECIVS IVEVLPRILK HSSRDVLLDM KFQWVQCVDF LLLHEMKAVR DAFSSVVSCF
     LETNAMDILF SDGTGMSGGT SRVKFMDKIK SAFTEAEDPQ ILLTLLESTA AIVKASDIHG
     EVFFCSFVLL IGQLGNHDYI VRVTALRLLQ RCCTYCFKGG LELFLSKYFH VRDNLYDYLS
     SRLLTHPVVI SEFAESVLGV KTEELIRRMV PSIIPKLIVS HQNNDQAVVT LNELASHLNS
     ELVPLIVNSL PKVLSFALFY EDGQHLSSVL QFYHTETGTD SKEIFSAALP TLLDEIICFP
     GESDQIETDR RMAKISPTIQ NIARILTGND NLPEFLKNDF VRLLNSIDKK MLHSSDVNLQ
     KQALQRIRKL VEMMGPYLST HAPKIMVLLI FAIDKETLQM DGLDVLHFFI KRLAEVSCTS
     IKYVMSQVVA AFIPSLERCR ERPLVHLGKI VEILEELVVK NIILLKQHIR ELPLLPSLPS
     LSGVNKVIQE ARGLMTLQDH LKDAVNGLNH ESLNVRYMVA CELNKLFNDR RGDITSLIIG
     EDIADLDIIS SLIMSLLKGC AEESRTVVGQ RLKLVCADCL GALGAVDPAK FKVMSCERFK
     IECSDDDLIF ELIHKHLARA FRAASDTTVQ DSAALAIQEL LKLSGCQSLP NESSSCKMSK
     RGQKLWGRFS SYVKEIIAPC LTSRFHLPSV NDATLAGPIY RPTMSFRRWI YYWIRKLTSH
     ATGSRSGIFG ACRGIVRHDM PTAIYLLPYL VLNVVCYGTP EARQSITEEI LSVLNAAASE
     SSGAIVHGIT GGQSEVCIQA VFTLLDNLGQ WVDDLKQEIA LSQSNYAMAG RQGGKLRDES
     NSMYDQDQLL VQCSNVAELL AAIPKVTLAK ASFRCQAHAR ALMYFESHVR EKSGSSNPAA
     DCSGAFSDDD ISFLMEIYGG LDEPDGLLGL ANLRKSSTLQ DQLIINEKAG NWAEVLTLCE
     QSLQMEPDSV HRHCDVLNCL LNMCHLQAMI AHVDGLVYRI PQSKKTWCMQ GVQAAWRLGR
     WDLMDEYLAE ADKGLVCRSS ENNASFDMGL AKIFNAMMKK DQFMVAEKIA QSKQALLVPL
     AAAGMDSYMR AYPYIVKLHM LRELEDFNSL LGDESFLEKP FAADDPKFLK LTKDWENRLR
     CTQPSLWARE PLLAFRRMVY NLSHMNAQAG NCWLQYARLC RLAGHYETAH RAILEADASG
     APNAHMEKAK YLWNIRKSDS AIAELQQTLL NMPADVLGPT VLSSLSSLSL ALPNAPLSVT
     QASKENPDVS KTLLLYTRWI HYTGQKQSND IKSLYSRVAD LRPKWEKGFF CIAKFYDDLL
     VDARRRQEDK KIASGVGPVP PSSTGSLTTA TEEKPWWDML PVVLIQYARG LHRGHKNLFQ
     ALPRLLTLWF EFGSIYIQDG SSFNKPMKEV HIRLLGIMRG CLKDLPPYQW LTVLSQLISR
     ICHQNIEVVK LVKCIVTSIL REYPQQALWM MAAVSKSTVA ARRDAAAEIL QSAKKGSRRG
     SDSNALFMQF PSLIDHLIKL CFHPGQPKAR AINISTEFSS LKRMMPLGII LPIQQALTVT
     LPSYDTNMTD QSTFRPFSVS EHPTIAGIAD DAEILNSLQK PKKVVFIGSD GISRPFLCKP
     KDDLRKDSRM MEFNAMINRL LSKVPESRRR KLYIRTFAVV PLTEDCGMVE WVPNTRGLRQ
     ILQDIYITCG KFDRMKTNPQ IKKIYDQLQG KMPEEMLKAK ILPMFPPVFH KWFLTTFSEP
     AAWIRARAAY AHTTAVWSMV GHIVGLGDRH GENILLDSTT GDCIHVDFSC LFDKGLLLEK
     PEVVPFRFTQ NMVDGLGITG YEGVFVKVCE ITLSVLRTHK EALMTVLETF IHDPLVEWTK
     SHKSSGVEVR NPHAQRAISN ITERLQGVVV GVNAAPSLPL SVEGQARRLI AEAVSHSNLG
     KMYVWWMAWF
 
 
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