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RPOC1_PLAF7
ID   RPOC1_PLAF7             Reviewed;         575 AA.
AC   P21422;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta';
DE            EC=2.7.7.6;
DE   AltName: Full=PEP;
DE   AltName: Full=Plastid-encoded RNA polymerase subunit beta';
DE            Short=RNA polymerase subunit beta';
GN   Name=rpoC1; Synonyms=rpoC;
OS   Plasmodium falciparum (isolate 3D7).
OG   Plastid; Apicoplast.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BW/C10;
RX   PubMed=8757284; DOI=10.1006/jmbi.1996.0449;
RA   Wilson R.J.M., Denny P.W., Preiser P.R., Rangachari K., Roberts K., Roy A.,
RA   Whyte A., Strath M., Moore D.J., Moore P.W., Williamson D.H.;
RT   "Complete gene map of the plastid-like DNA of the malaria parasite
RT   Plasmodium falciparum.";
RL   J. Mol. Biol. 261:155-172(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-462.
RX   PubMed=2011147; DOI=10.1016/0166-6851(91)90227-w;
RA   Gardner M.J., Williamson D.H., Wilson R.J.M.;
RT   "A circular DNA in malaria parasites encodes an RNA polymerase like that of
RT   prokaryotes and chloroplasts.";
RL   Mol. Biochem. Parasitol. 44:115-124(1991).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6;
CC   -!- SUBUNIT: In plastids the minimal PEP RNA polymerase catalytic core is
CC       composed of four subunits: alpha, beta, beta', and beta''. When a
CC       (nuclear-encoded) sigma factor is associated with the core the
CC       holoenzyme is formed, which can initiate transcription (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Plastid, apicoplast.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC       {ECO:0000305}.
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DR   EMBL; X95275; CAA64573.1; -; Genomic_DNA.
DR   EMBL; X52177; CAA36428.1; -; Genomic_DNA.
DR   PIR; S10439; S10439.
DR   PIR; S72283; S72283.
DR   AlphaFoldDB; P21422; -.
DR   SMR; P21422; -.
DR   STRING; 36329.P21422; -.
DR   PRIDE; P21422; -.
DR   VEuPathDB; PlasmoDB:PF3D7_API04300; -.
DR   InParanoid; P21422; -.
DR   PhylomeDB; P21422; -.
DR   Proteomes; UP000001450; Apicoplast A.
DR   GO; GO:0020011; C:apicoplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR   InterPro; IPR000722; RNA_pol_asu.
DR   InterPro; IPR006592; RNA_pol_N.
DR   InterPro; IPR007080; RNA_pol_Rpb1_1.
DR   PANTHER; PTHR19376; PTHR19376; 1.
DR   Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR   Pfam; PF00623; RNA_pol_Rpb1_2; 2.
DR   SMART; SM00663; RPOLA_N; 1.
PE   3: Inferred from homology;
KW   Apicoplast; DNA-directed RNA polymerase; Nucleotidyltransferase; Plastid;
KW   Reference proteome; Transcription; Transferase.
FT   CHAIN           1..575
FT                   /note="DNA-directed RNA polymerase subunit beta'"
FT                   /id="PRO_0000074039"
SQ   SEQUENCE   575 AA;  69406 MW;  56267C7458EB716D CRC64;
     MIIHNNINFI GLKLNILNPK QIIKWSSIFY KNKIIIGEVL IPNTINFNTG LPILNGLFCE
     KIFDYMYKWN CNCNKKMYNI NNFSFFLYCK FCKNKLIINI NRKYKLGFIF LNIPILHLWY
     LTGPLKVASL LLNKNVFYLK FLIYYKYFFS NIKYKQYFYY NKLFSKINLY KKKYKNIIQY
     LFSHNILYKK LQNINLLTEL LNNKELLLIN NKYYNKKYLY KKINLFNLFI LNNIKPNWIF
     LDLLPILPAG LRPYFYINNS TYIISTINEN YRLIILKNNK LKYWLYLRNN IFFIFEIIEK
     RLLQQLIDYL LINKLILKNN NTFFNFSKTF QGKYSTIKYK LLGKRVDFSG RSVITVNPSI
     IYNNIGLPYY ISINLFKPFL INILKYNSKL NIIFKSLLIN KNLFIIQKFL NRLLQNQFII
     INRAPTLHRM NLQSFKPLLT EGYSLKFYPL GCTSFNADFD GDQMSIFLPL IKTSKFESNI
     NLNFDKNIIS PSNNKNLFSN LQYYKLGINT LLILNYNNEL NIFYFNSIEK IYEYYNNNIL
     FIFNLVWIKY INNNNIFYIL TSINRIIINL YMYIY
 
 
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