RPOC1_PROSC
ID RPOC1_PROSC Reviewed; 203 AA.
AC P42078;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=DNA-directed RNA polymerase subunit gamma;
DE Short=RNAP subunit gamma;
DE EC=2.7.7.6;
DE AltName: Full=RNA polymerase subunit gamma;
DE AltName: Full=Transcriptase subunit gamma;
DE Flags: Fragment;
GN Name=rpoC1;
OS Prochloron sp.
OC Bacteria; Cyanobacteria; Synechococcales; Prochloraceae; Prochloron;
OC unclassified Prochloron.
OX NCBI_TaxID=1215;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1731224; DOI=10.1038/355265a0;
RA Palenik B., Haselkorn R.;
RT "Multiple evolutionary origins of prochlorophytes, the chlorophyll b-
RT containing prokaryotes.";
RL Nature 355:265-267(1992).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000250|UniProtKB:P0A8T7};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000250|UniProtKB:P0A8T7};
CC Note=Binds 1 Zn(2+) ion per subunit. {ECO:0000250|UniProtKB:P0A8T7};
CC -!- SUBUNIT: In cyanobacteria the RNAP catalytic core is composed of 2
CC alpha, 1 beta, 1 beta', 1 gamma and 1 omega subunit. When a sigma
CC factor is associated with the core the holoenzyme is formed, which can
CC initiate transcription (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family. RpoC1
CC subfamily. {ECO:0000305}.
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DR EMBL; Z11161; CAA77512.1; -; Genomic_DNA.
DR PIR; S20586; S20586.
DR AlphaFoldDB; P42078; -.
DR SMR; P42078; -.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 4.10.860.120; -; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR PANTHER; PTHR19376; PTHR19376; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Metal-binding; Nucleotidyltransferase;
KW Transcription; Transferase; Zinc.
FT CHAIN <1..>203
FT /note="DNA-directed RNA polymerase subunit gamma"
FT /id="PRO_0000067849"
FT BINDING 34
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P0A8T7"
FT BINDING 36
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P0A8T7"
FT BINDING 49
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P0A8T7"
FT BINDING 52
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P0A8T7"
FT NON_TER 1
FT NON_TER 203
SQ SEQUENCE 203 AA; 23389 MW; 94088DEEEDDAD9F2 CRC64;
EVTKPETINY RTLKPEMDGL FCERIFGPAK DWECHCGKYK RVRYKGIVCE RCGVEVTESK
VRRHRMGYIK LAAPVTHVWY LKGIPSYMSI ILDMPLRDVE QIVYFNAYVV LDPGNAQNLS
YKQLLTEDQW LEIEEQIYGE DSELLGIEVG IGAEAVKRLL EEVDKTSEAE KLRSEIANCK
GQKRAKLIKR LRVIDNFVAT GSR
